Figures S1-S8 from Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation

Le résumé fourni par la source

Figure S1: Knockdown of MALAT1 inhibits proliferation of liver progenitor and HCC cells. Figure S2: Effect of MALAT1 expression on splicing of endogenous SRSF1 targets. Figure S3. Differential gene expression based on RNA-seq data. Figure S4. Enriched pathways and networks activated by overexpression of MALAT1 based on RNA-seq analysis. Figure S5 Enriched pathways activated by MALAT1 overexpression based on RNA-seq analysis. Figure S6. Validation of MALAT1 up- and down-regulated genes identified by RNA-seq analysis. Figure S7. Knockdown of MALAT1 down-regulates c-Myc protein levels. Figure S8. Knockdown of SRSF1 inhibits oncogenesis downstream to MALAT1 and only partially inhibits transformation by oncogenic Ras.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.