Elevated concentrations of macrophage migration inhibitory factor in serum and cerebral microdialysate are associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
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Le résumé fourni par la source
Objective Inflammation is increasingly recognized to be involved in the pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH) and may increase the susceptibility to delayed cerebral ischemia (DCI). Macrophage migration inhibitory factor (MIF) has been shown to be elevated in serum and cerebrospinal fluid (CSF) after aSAH. Here, we determined MIF levels in serum, CSF and cerebral microdialysate (MD) at different time-points after aSAH and evaluated their clinical implications. Methods MIF levels were measured in serum, CSF and MD obtained from 30 aSAH patients during early (EPd1−4), critical (CPd5−15) and late (LPd16−21) phase after hemorrhage. For subgroup analyses, patients were stratified based on demographic and clinical data. Results MIF levels in serum increased during CPd5−15 and decreased again during LPd16−21, while CSF levels showed little changes over time. MD levels peaked during EPd1−4, decreased during CPd5−15 and increased again during LPd16−21. Subgroup analyses revealed significantly higher serum levels in patients with aneurysms located in the anterior vs. posterior circulation during CPd5−15 (17.3 [15.1–21.1] vs. 10.0 [8.4–11.5] ng/ml, p = 0.009) and in patients with DCI vs. no DCI during CPd5−15 (17.9 [15.1–22.7] vs. 11.9 [8.9–15.9] ng/ml, p = 0.026) and LPd16−21 (17.4 [11.7–27.9] vs. 11.3 [9.2–12.2] ng/ml, p = 0.021). In addition, MIF levels in MD during CPd5−15 were significantly higher in patients with DCI vs. no DCI (3.6 [1.8–10.7] vs. 0.2 [0.1–0.7] ng/ml, p = 0.026), while CSF levels during the whole observation period were similar in all subgroups. Conclusion Our findings in a small cohort of aSAH patients provide preliminary data on systemic, global cerebral and local cerebral MIF levels after aSAH and their clinical implications. Clinical trial registration ClinicalTrials.gov , identifier: NCT02142166.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Elevated concentrations of macrophage migration inhibitory factor in serum and cerebral microdialysate are associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
- Date Crossref
- 13/01/2023
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Forschungszentrum Jülich pays non établi dans la noticeStructure de recherche
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University of Cologne pays non établi dans la noticeUniversité ou école supérieure
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Universitätsklinikum Aachen pays non établi dans la noticeÉtablissement de santé
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University Hospital Cologne Institute of Radiochemistry and Experimental Molecular Imaging pays non établi dans la noticeÉtablissement de santé
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RWTH Aachen University Department of Neurosurgery pays non établi dans la noticeUniversité ou école supérieure
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University of Würzburg pays non établi dans la noticeUniversité ou école supérieure
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Charité - Universitätsmedizin Berlin pays non établi dans la noticeÉtablissement de santé
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Kantonsspital Aarau pays non établi dans la noticeÉtablissement de santé
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Maastricht University Department of Neurosurgery pays non établi dans la noticeUniversité ou école supérieure
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Institute of Neuroscience and Medicine pays non établi dans la noticeStructure de recherche
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Würzburg University Department of Anesthesiology and Intensive Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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Departments of Cardiac Anesthesiology and Intensive Care Medicine Charité pays non établi dans la noticeInstitution
Forschungszentrum Jülich, University of Cologne et Universitätsklinikum Aachen, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.