Facilitating glaucoma diagnosis with inter-eye neuroretinal rim asymmetry analysis using spectral domain optical coherence tomography
Rattachement africain : us, nl. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Purpose: To determine if inter-eye asymmetry of a three-dimensional neuroretinal rim parameter, the minimum distance band, is useful in differentiating normal from open-angle glaucoma eyes. Materials and Methods: This is a cross-sectional study. Both eyes of 28 normal subjects 33 glaucoma subjects were analyzed. Subjects underwent spectral domain optical coherence tomography imaging of both eyes. A custom-designed segmentation algorithm calculated mean minimum distance band neuroretinal rim thickness globally, for four quadrants and for four sectors. Inter-eye minimum distance band thickness asymmetry was calculated as the absolute difference in minimum distance band thickness values between the right and left eyes. Results: Increasing minimum distance band thickness asymmetry was not associated with increasing age or increasing refractive error asymmetry. Glaucoma patients had thinner mean neuroretinal rim thickness values compared to normal patients (209.0 μm versus 306.0 μm, P < 0.001). Glaucoma subjects had greater inter-eye thickness asymmetry compared to normal subjects for the global region (51.9 μm versus 17.6 μm, P < 0.001) as well as for all quadrants and all sectors. For detecting glaucoma, a thickness asymmetry value greater than 28.3 μm in the inferior quadrant yielded the greatest sum of sensitivity (87.9%) and specificity (75.0%). Globally, thickness asymmetry greater than 30.7 μm yielded the greatest sum of sensitivity (66.7%) and specificity (89.3%). Discussion: This study indicates that inter-eye neuroretinal rim minimum distance band asymmetry measurements, using high-density spectral domain optical coherence tomography volume scans, may be an objective and quantitative tool for the evaluation of open-angle glaucoma patients.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Facilitating glaucoma diagnosis with inter-eye neuroretinal rim asymmetry analysis using spectral domain optical coherence tomography
- Date Crossref
- 26/12/2022
- Éditeur
- Digital Journal of Opthalmology
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Massachusetts Eye and Ear Infirmary pays non établi dans la noticeÉtablissement de santé
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Massachusetts General Hospital Martinos Center for Biomedical Imaging pays non établi dans la noticeÉtablissement de santé
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Athinoula A. Martinos Center for Biomedical Imaging pays non établi dans la noticeStructure de recherche
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Amsterdam University Medical Centers Department of Ophthalmology pays non établi dans la noticeÉtablissement de santé
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Vrije Universiteit Amsterdam LaserLaB Amsterdam pays non établi dans la noticeUniversité ou école supérieure
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Department of Ophthalmology pays non établi dans la noticeInstitution
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Harvard Medical School pays non établi dans la noticeInstitution
Massachusetts Eye and Ear Infirmary, Harvard University et Martinos Center for Biomedical Imaging — Massachusetts General Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.