Immunohistochemical expression of p53, Ki67, α-SMA, CD44 and CD31 in different histological subtypes of basal cell carcinoma
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Le résumé fourni par la source
Basal cell carcinoma (BCC) is a common, locally invasive tumor that arises within sun-damaged skin and rarely develops on the palms and soles or mucous membranes. Men generally have higher rates of BCC than women. Incidence also increases with age and the median age of diagnosis is 68 years old. Mortality from BCC is rare and cases of aggressive, local destructive, metastatic BCCs are more likely from tumors with aggressive histopathological (HP) patterns. The aim of this study was to investigate and correlate the immunohistochemical expression of p53, Ki67, alpha-smooth muscle actin (α-SMA), cluster of differentiation (CD)44 and CD31 with both aggressive and nonaggressive types of BCCs. In our study, we observed a varied staining pattern for p53, with the highest reactivity noticed in the peripheral palisading zone. The staining pattern for Ki67 was similar to p53, with a more pronounced reaction in the periphery of the tumor. We found different Ki67 and p53 expression among the various subtypes of BCC. The CD31 reactivity, mostly seen in the stroma, was positive in all BCCs and varied significantly between its different HP subtypes. Regarding stromal expression of α-SMA, the adenoid and basosquamous types had the most intense reaction in our study. The CD44 tumor expression was correlated in our study to the aggressive pattern of BCCs.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Immunohistochemical expression of p53, Ki67, α-SMA, CD44 and CD31 in different histological subtypes of basal cell carcinoma
- Date Crossref
- 12/11/2022
- Éditeur
- Societatea Romana de Morfologie
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Clinical Emergency Hospital Bucharest pays non établi dans la noticeÉtablissement de santé
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University of Medicine and Pharmacy of Craiova Department of Oncology pays non établi dans la noticeUniversité ou école supérieure
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Emergency University ) Department of Dermatology pays non établi dans la noticeUniversité ou école supérieure
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Carol Davila University of Medicine and Pharmacy ) Department of Dermatology pays non établi dans la noticeUniversité ou école supérieure
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Morpho (United States) pays non établi dans la noticeEntreprise
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Department of Embryology pays non établi dans la noticeStructure de recherche
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Universitatea Națională de Știință și Tehnologie Politehnica București pays non établi dans la noticeUniversité ou école supérieure
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Romanian Journal of Morphology & Embryology pays non établi dans la noticeInstitution
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Faculty of Industrial Engineering and Robotics ) Department of Machine Construction Technology pays non établi dans la noticeUniversité ou école supérieure
Clinical Emergency Hospital Bucharest, Department of Oncology — University of Medicine and Pharmacy of Craiova et ) Department of Dermatology — Emergency University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.