Accès ouvert déclaré
2022
article
Depressive symptoms after hepatitis C cure and socio-behavioral correlates in aging people living with HIV (ANRS CO13 HEPAVIH)
Fabienne Marcellin, Sylvie Brégigeon, Clémence Ramier, Camélia Protopopescu, Camille Gilbert, Vincent Di Beo, Claudine Duvivier, Morgane Bureau-Stoltmann, Éric Rosenthal, Linda Wittkop, Dominique Salmon‐Céron, Patrizia Carrieri, Philippe Sogni, Tangui Barré, D Salmon, R. Usubillaga, Benoît Terris, P. Tremeaux, Christine Katlama, M.A. Valantin, Hind Stitou, Alissa Simon, P. Cacoub, S. Nafissa, Y. Benhamou, Frédéric Charlotte, Virologie S. Fourati, Isabelle Poizot‐Martin, O. Zaegel, Hélène Laroche, Catherine Tamalet, Gilles Pialoux, J. Chas, P Callard, F. Bendjaballah, Corinne Amiel, C. Le Pendeven, B. Marchou, Laurent Alric, Karl Barange, Sophie Métivier, J. Selves, F. Larroquette, Infectiologie, A. Naqvi, V. Rio, Juliette Haudebourg, M Saint-Paul, Anne De Monte, V. Giordanengo, C. Partouche, Olivier Bouchaud, A. Martin, Marianne Ziol, Y. Baazia, V. Iwaka-Bande, A. Gerber, M. Uzan, A. Bicart-See, D. Garipuy, M.J. Ferro-Collados, Virologie, Florence Nicot, A. Gervais, Yazdan Yazdanpanah, Homa Adle‐Biassette, Guy P. Alexandre, G. Peytavin, Caroline Lascoux‐Combe, Jean‐Michel Molina, P Bertheau, Marie‐Laure Chaix, Constance Delaugerre, Sarah Maylin, Karine Lacombe, Julie Bottero, Jessica Krause, PM Girard, Dominique Wendum, Pascale Cervera, Jamila Khatoon Adam, C. Viala, D. Vittecocq, Cécile Goujard, Yann Quertainmont, Elina Teicher, C. Pallier, Olivier Lortholary, C. Rouzaud, J. Lourenco, F. Touam, C. Louisin, Véronique Avettand-Fènoël, Elise Gardiennet, A. Mélard, D. Neau, Ayako Miyashita Ochoa, E. Blanchard, S. Castet-Lafarie, Charles Cazanave, D. Malvy, M. Dupon, H. Dutronc, F. Dauchy, L. Lacaze-Buzy, Alice Desclaux, Paulette Bioulac‐Sage, P. Trimoulet, Sandrine Reigadas, P. Morlat, D. Lacoste, Fabrice Bonnet, N. Bernard, Mojgan Hessamfar, J, F. Paccalin, Christopher R. Martell, M. C. Pertusa, M. Vandenhende, P. Mercié, T. Pistone, M. C. Receveur, M. Méchain, P. Duffau, C. Rivoisy, I. Faure, S. Caldato, Pantxika Bellecave, C. Tumiotto, J.L. Pellegrin, J.F. Viallard, E. Lazzaro, C. Greib, David Zucman, C. Majerholc, M. Brollo, E. Farfour, François Boué, J. Polo Devoto, Imad Kansau, V. Chambrin, C. Pignon, L. Berroukeche, R Fior, Valérie Martinez, Sophie Abgrall, M. Favier, Claire Deback, Yves Lévy, S. Dominguez, Jean‐Daniel Lelièvre, Anne‐Sophie Lascaux, Giovanna Melica, E. Billaud, F. Raffi, Clotilde Allavena, V. Reliquet, D. Boutoille, C. Biron, M. Lefèbvre, Nancy Hall, Sabelline Bouchez, Audrey Rodallec, L. Le Guen, C. Hemon, P. Miailhes, D. Peyramond, Christian Chidiac, Florence Ader, F. Biron, A. Boibieux, Laurent Cotte, Tristan Ferry, T. Perpoint, J. Koffi, Fabien Zoulim, François Bailly, Philippe Lack, Michaela Maynard, Sylvie Radenne, M. Amiri, Florent Valour, C. Augustin-Normand, C. Scholtes, T.T. Le-Thi, L Piroth, P. Chavanet, M. Duong Van Huyen, M. Buisson, A. Waldner-Combernoux, S. Mahy, Andréas Rousseau, Camila Marinelli Martins, Hugues Aumaître, S. Galim, Firouzé Bani‐Sadr, D. Lambert, Yen Nguyen, J. Berger, Maxime Hentzien, V. Brodard, Dominique Rey, M Partisani, M.L. Batard, C. Cheneau, M. Priester, Claudine Bernard-Henry, E. de Mautort, P Fischer, Pierre Gantner, Samira Fafi‐Kremer, F. Roustant, P. Platterier, I. Kmiec, L. Traore, S. Lepuil, S. Parlier, V. Sicart-Payssan, E. Bedel, S. Anriamiandrisoa, Chloe Pomes, M.Leonard Mole, C. Bolliot, P. Catalán, M. Mebarki, A. Adda-Lievin, P. Thilbaut, Y. Ousidhoum, F.Z. Makhoukhi, O. Braik, R. Bayoud, Caroline Gatey, M P Pietri, V. Le Baut, Raida Ben Rayana, Dominique Bornarel, C. Chesnel, D. Beniken, M. Pauchard, S. Akel, C. Lions, A Ivanova, A.-S. Ritleg, C. Debreux, L. Chalal, J. Zelie, H. Hue, Ainara Soria, M. Cavellec, S. Breau, A. Joulié, Peter Fisher, Sandrine Gohier, Delphine Croisier, S. Ogoudjobi, C. Brochier, V. Thoirain-Galvan, M. Le Cam, Laure Esterle, Jacques Izopet, Lawrence Serfaty, Valérie Paradis, Bruno Spire, Olivia Zaegel‐Faucher, Laurence Meyer, F. Boufassa, Brigitte Autran, A.M. Roque, Caroline Solas, Hélène Fontaine, Dominique Costagliola, V. Petrov-Sanchez, Axel Levier, M. Chalouni, Valérie Conte, L. Dequae-Merchadou, Mathilde Desvallées, S. Gillet, Q. Guillochon, Christina T. Khan, Rod Knight, Laurent Michel, Marion Mora, Perrine Roux, A. Sow, Mathilde Bureau
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Résumé fourni par la source
Background & Aims: A growing literature shows an improvement of chronic hepatitis C virus (HCV)-related depression after successful treatment with direct-acting antivirals. However, depression after HCV cure remains insufficiently documented in people living with HIV (PLWH) and HCV, a population with specific mental health challenges. This study aimed to (i) document the prevalence of moderate-to-severe depression (PHQ-9 score ≥10) across different age classes in HCV-cured PLWH; (ii) identify associated socio-behavioral correlates. Methods: Descriptive analyses were performed on data collected during a cross-sectional survey (February 2018 - May 2019) nested in a prospective, multicenter cohort of individuals living with HIV and HCV (ANRS CO13 HEPAVIH). Socio-behavioral correlates of moderate-to-severe depression were identified using logistic regression. Results: Among the 398 HCV-cured individuals in the study sample (median age [IQR]: 56 [53-59] years; 73.1% men), 23.9% presented with moderate-to-severe depression (PHQ-9 score ≥10). Depressive symptom prevalence rates were as follows: anhedonia: 52.3%; feeling 'down' or feelings of hopelessness: 48.3%; sleeping problems: 65.7%; lack of energy: 70.3%; eating disorders: 51.2%; lack of self-esteem: 34.3%; difficulty concentrating: 34.9%; sluggishness (in movement and voice) or restlessness: 24.6%; suicidal ideation: 17.1%. No significant difference was detected across age classes. Female sex, unhealthy alcohol use, sedentary lifestyle, and unhealthy eating behaviors were associated with increased odds of moderate-to-severe depression. Conclusions: Depressive symptoms were common in this sample of HCV-cured PLWH. Unlike findings for the French general population, the prevalence of depression did not decrease with age class. Mental health remains a key issue for HIV-HCV-coinfected individuals, even after HCV cure, especially in women and in individuals with unhealthy behaviors. Lay summary: Despite potential improvements in mental health after successful treatment with direct-acting antivirals, many people living with HIV (PLWH) and hepatitis C virus (HCV) - even in older age classes - still face depressive symptoms after HCV cure. In this population, women and people reporting unhealthy alcohol use, sedentary lifestyle, or unhealthy eating behaviors are more prone to report depressive symptoms after HCV cure. Mental health and lifestyle-related issues should be integrated in a global care model for PLWH living with or having a history of hepatitis C.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Depressive symptoms after hepatitis C cure and socio-behavioral correlates in aging people living with HIV (ANRS CO13 HEPAVIH)
- Date Crossref
- 01/01/2023
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Hepatitis C virus researchDiabetes Management and EducationCardiac Health and Mental Health