Accès ouvert déclaré
2020
review
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Ken K. Ong, Blair H. Smith, Barbara McKnight, Louis Përusse, Hans J. Grabe, Pedro Marques‐Vidal, Jaspal S. Kooner, Nicholas J. Wareham, Andrew P. Morris, Tanja B. Grammer, Martina Chittani, Maija Hassinen, Stella Trompet, Markus Juonala, Charles Kooperberg, Annette Peters, Joseph C. Wu, Johanna Kuusisto, M. Carola Zillikens, Marcel Bruinenberg, Anna L. Eriksson, Ani Manichaikul, Caroline S. Fox, Harold Snieder, Llilda Barata, Henrik Vestergaard, Ozren Polašek, Ingrid B. Borecki, Nicholas G. Martin, Tarunveer S. Ahluwalia, Naveed Sattar, Dan Mellström, Paul W. Franks, Joel N. Hirschhorn, Heather M. Stringham, Mika Kivimäki, Marjo‐Riitta Järvelin, Francesco Cucca, Audrey Y. Chu, Lynne J. Hocking, Oddgeir L. Holmen, Tanguy Corre, Reija Männikkö, J. Wouter Jukema, Jaakko Tuomilehto, Gerard Pasterkamp, Bruce H. R. Wolffenbuttel, Dena Hernández, Ian Ford, Iris M. Heid, Inês Barroso, Rajesh Rawal, Najaf Amin, Catharina A. Hartman, Bamidele O. Tayo, Karl Gertow, Neşe Direk, Mattias Lorentzon, Tõnu Esko, Joel Eriksson, Saima Afaq, Cornelia M. van Duijn, Mélanie Waldenberger, Beverley Balkau, Jian Ping Gong, Natalia Pervjakova, Kristin L. Young, Damiano Baldassarre, Loïc Yengo, Anne E. Justice, Jian’an Luan, Alexander Teumer, Bruna Gigante, Momoko Horikoshi, Lenore J. Launer, Harald Grallert, Julius S. Ngwa, Ying Wu, Anja Ludolph-Donislawski, Rao, Dorothée Thuillier, Frida Renström, Lucia A. Hindorff, Peter S. Chines, Stéphane Lobbens, Stavroula Kanoni, Martina Müller‐Nurasyid, John‐Olov Jansson, Pau Navarro, Eco J. C. de Geus, Lynda M. Rose, Kai Savonen, Unhee Lim, David J. Hunter, Cinzia Sarti, Lawrence F. Bielak, Rainer Rauramaa, John B. Whitfield, Nicholas D. Hastie, Stefania Bandinelli, Morris A. Swertz, Amy J. Swift, Mika Kähönen, Xuan Deng, Mathias Gorski, Ulf dé Fairé, Magnus Karlsson, Marten A. Siemelink, Narisu Narisu, Andrew D. Johnson, Gitta H. Lubke, Andrew L. Wong, Jeremiah Perez, Niek Verweij, Niels Grarup, Salome Scholtens, Kirsti Kvaløy, Mark I. McCarthy, Eric Boerwinkle, Markku Laakso, Stephan J. L. Bakker, Jessica Tyrrell, Daniel I. Chasman, Anton J. M. de Craen, John C. Chambers, Bernhard Krämer, Tao Huang, John D. Eicher, Nina Hutri‐Kähönen, Marie Loh, Sven Bergmann, David R. Weir, Matthias Nauck, Winfried März, Cecilia M. Lindgren, Jennifer A. Smith, Rita P. S. Middelberg, Zoltán Kutalik, Qibin Qi, Tim D. Spector, Kristian Hveem, Bruce M. Psaty, Richard N. Bergman, Torben Hansen, Georg Homuth, Rona J. Strawbridge, Konstantin Strauch, Saskia Haitjema, Weihua Zhang, Anne Jackson, Brendan M. Buckley, Gert J. de Borst, Jan A. Staessen, Péter Vollenweider, Ching‐Ti Liu, Claudia Schurmann, L. Adrienne Cupples, Jonathan Marchini, Claes Ohlsson, Alan F. Wright, Sarah H. Wild, Mette Hollensted, Kari E. North, Jennifer Bragg, Joseph Hung, Penny Gordon‐Larsen, Heikki A. Koistinen, Matthias Olden, Krista Fischer, Barbara Thorand, Marie Neergaard Harder, Günther Silbernagel, Jennifer E. Huffman, Göran Hallmans, Ilja M. Nolte, Loı̈c Le Marchand, Martina E. Zimmermann, Scott Coggeshall, Dorret I. Boomsma, David P. Strachan, Lu Qi, Marit E. Jørgensen, Gemma Cadby, Liesbeth Vandenput, Elena Tremoli, David J. Porteous, Gonçalo R. Abecasis, Colin A. McKenzie, George Dedoussis, Diana Kuh, Anders Hamsten, Lori L. Bonnycastle, Allan Linneberg, Sander W. van der Laan, Laura J. Rasmussen‐Torvik, Lars Lind, Jessica D. Faul, Thomas W. Winkler, Min A. Jhun, Westendorp, Jing Zhao, Genovefa Kolovou, Igor Rudan, Claudia Langenberg, Sharon L. R. Kardia, Pamela A. F. Madden, Joanne E. Curran, Uzma Afzal, Anubha Mahajan, Leo‐Pekka Lyytikäinen, Linda S. Adair, Tamuno Alfred, Pim van der Harst, Karen L. Mohlke, Henry Völzke, Daniele Cusi, Patricia A. Peyser, Timothy M. Frayling, Pirjo Komulainen, Luigi Ferrucci, Alena Stančáková, Guðný Eiríksdóttir, Andres Metspalu, Robert A. Scott, Yii‐Der Ida Chen, Virginia Fisher, Sara Lupoli, Shafqat Ahmad, Traci M. Bartz, Harry Campbell, Jana V. van Vliet‐Ostaptchouk, John Blangero, Musk, Toshiko Tanaka, Tuomo Rankinen, Tuomas O. Kilpeläinen, Serena Sanna, Michael Boehnke, Tamara B. Harris, Marcus E. Kleber, Paul M. Ridker, Leena Kinnunen, Caroline Hayward, Cristina Menni, Daniele Braga, Henning Tiemeier, Carsten A. Böger, Véronique Vitart, Treva Rice, Wei Zhao, Kent D. Taylor, Jacqueline M. Vink, Misa Graff, James F. Wilson, Thorkild I. A. Sørensen, Sailaja Vedantam, Reiner Biffar, Ivana Kolčić, Gonneke Willemsen, Amélie Bonnefond, Judith M. Vonk, Nicola Glorioso, Timo A. Lakka, Luting Xue, Elise Lim, Andrew C. Heath, Ruth J. F. Loos, Christopher A. Haiman, Lyle J. Palmer, Terrence Forrester, Bengt Sennblad, Peter J. van der Most, Vilmundur Guðnason, Francis S. Collins, Sang Lee, Karin Leander, Graciela E. Delgado, John Beilby, Robert Luben, Stephanie A. Bien, Charlotta Pisinger, André G. Uitterlinden, Albertine J. Oldehinkel, Niha Zubair, Grant W. Montgomery, Marie‐Claude Vohl, Massimo Mangino, Mark A. Sarzynski, Gérard Waeber, Olli Raitakari, Johanne Marie Justesen, David Hadley, Albert V. Smith, Meena Kumari, David Schlessinger, Terho Lehtimäki, Mary F. Feitosa, Nancy L. Heard‐Costa, Hester M. den Ruijter, Erwin P. Böttinger, Sandosh Padmanabhan, Jacek Czajkowski, Oluf Pedersen, Claude Bouchard, P. Eline Slagboom, Steven Buyske, David J. Stott, Jonathan Marten, Philippe Froguel, Jie Huang, Erik Ingelsson
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2Pays d’affiliation déclarés
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Le résumé fourni par la source
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
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Les sujets associés
Nutrition, Genetics, and Disease