Quantification and Predictors of OCT-Based Macular Curvature and Dome-Shaped Configuration: Results From the UK Biobank
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Le résumé fourni par la source
Purpose: To investigate macular curvature, including the evaluation of potential associations and the dome-shaped macular configuration, given the increasing myopia prevalence and expected associated macular malformations. Methods: The study included a total of 65,440 subjects with a mean age (± SD) of 57.3 ± 8.11 years with spectral-domain optical coherence tomography (OCT) data from a unique contemporary resource for the study of health and disease that recruited more than half a million people in the United Kingdom (UK Biobank). A deep learning model was used to segment the retinal pigment epithelium. The macular curvature of the OCT scans was calculated by polynomial fit and evaluated. Further, associations with demographic, functional, ocular, and infancy factors were examined. Results: The overall macular curvature values followed a Gaussian distribution with high inter-eye agreement. Although all of the investigated parameters, except maternal smoking, were associated with the curvature in a multilinear analysis, ethnicity and refractive error consistently revealed the most significant effect. The prevalence of a macular dome-shaped configuration was 4.8% overall, most commonly in Chinese subjects as well as hypermetropic eyes. An increasing frequency up to 22.0% was found toward high refractive error. Subretinal fluid was rarely found in these eyes. Conclusions: Macular curvature revealed associations with demographic, functional, ocular, and infancy factors, as well as increasing prevalence of a dome-shaped macular configuration in high refractive error including high myopia and hypermetropia. These findings imply different pathophysiologic processes that lead to macular development and might open new fields to future myopia and macula research.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Quantification and Predictors of OCT-Based Macular Curvature and Dome-Shaped Configuration: Results From the UK Biobank
- Date Crossref
- 25/08/2022
- Éditeur
- Association for Research in Vision and Ophthalmology (ARVO)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Moorfields Eye Hospital NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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University of Bonn Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Augsburg pays non établi dans la noticeÉtablissement de santé
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Moorfields Eye Hospital pays non établi dans la noticeÉtablissement de santé
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University College London Institute of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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University of Washington Department of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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King's College London pays non établi dans la noticeUniversité ou école supérieure
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Macula Center pays non établi dans la noticeInstitution
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School of Life Course Sciences Section of Academic Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
Moorfields Eye Hospital NHS Foundation Trust, Department of Ophthalmology — University of Bonn et University Hospital Augsburg, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.