Early-life farm exposures and eczema among adults in the Agricultural Lung Health Study
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Le résumé fourni par la source
Background: Several studies conducted in Europe have suggested a protective association between early-life farming exposures and childhood eczema or atopic dermatitis; few studies have examined associations in adults. Objectives: To investigate associations between early-life exposures and eczema among 3217 adult farmers and farm spouses (mean age 62.8 years) in a case-control study nested within an US agricultural cohort. Methods: We used sampling-weighted logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for associations between early-life exposures and self-reported doctor-diagnosed eczema (273 cases) and polytomous logistic regression to estimate ORs (95%CIs) for a 4-level outcome combining information on eczema and atopy (specific IgE≥0.35). Additionally, we explored genetic and gene-environment associations with eczema. Results: Although early-life farming exposures were not associated with eczema overall, several early-life exposures were associated with a reduced risk of having both eczema and atopy. Notably, results suggest stronger protective associations among individuals with both eczema and atopy than among those with either atopy alone or eczema alone. For example, ORs (95%CIs) for having a mother who did farm work while pregnant were 1.01 (0.60-1.69) for eczema alone and 0.80 (0.65-0.99) for atopy alone, but 0.54 (0.33-0.80) for having both eczema and atopy. A genetic risk score based on previously identified atopic dermatitis variants was strongly positively associated with eczema, and interaction testing suggested protective effects of several early-life farming exposures only in individuals at lower genetic risk. Conclusions: and childhood farming exposures are associated with decreased odds of having eczema with atopy in adults.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Early-life farm exposures and eczema among adults in the Agricultural Lung Health Study
- Date Crossref
- 01/11/2022
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Institutes of Health pays non établi dans la noticeOrganisme public
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National Institute of Environmental Health Sciences Epidemiology Branch pays non établi dans la noticeStructure de recherche
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Haukeland University Hospital Department of Occupational Medicine pays non établi dans la noticeÉtablissement de santé
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University of Bergen Department of Clinical Science pays non établi dans la noticeUniversité ou école supérieure
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Old Dominion University Department of Mathematics and Statistics pays non établi dans la noticeUniversité ou école supérieure
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Westat (United States) pays non établi dans la noticeEntreprise
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Department of Health and Human Services pays non établi dans la noticeOrganisme public
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Westat Inc pays non établi dans la noticeEntreprise
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National Cancer Institute Occupational and Environmental Epidemiology Branch pays non établi dans la noticeStructure de recherche
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Inflammation and Disease Laboratory Immunity pays non établi dans la noticeStructure de recherche
National Institutes of Health, Epidemiology Branch — National Institute of Environmental Health Sciences et Department of Occupational Medicine — Haukeland University Hospital, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.