Effects of Pelargonium sidoides extract EPs 7630 on acute cough and quality of life – a meta-analysis of randomized, placebo-controlled trials
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Le résumé fourni par la source
Background: Cough is a leading symptom of viral acute respiratory infections such as acute bronchitis (AB) and the common cold (CC), which can be debilitating and may persist for several weeks. We investigated whether treatment with Pelargonium extract EPs 7630 may reduce cough and improve disease-related quality of life (QoL).Methods: We performed a meta-analysis of randomized, placebo-controlled trials investigating the efficacy of EPs 7630 in AB or CC. Efficacy analyses included change from baseline in a cough intensity score, remission of cough, and disease-associated impairments of QoL.Results: Data of 2,195 participants from 11 trials (3 in children/adolescents with AB, 3 in adults with AB, 5 in adults with CC) were eligible. In children/adolescents with AB, 79.6% of participants treated with EPs 7630 and 41% treated with placebo showed a reduction in intensity of cough by at least 50% of baseline values at day 7 [meta-analysis rate/risk ratio (RR), EPs 7630 / placebo: 1.86 (95% CI: 1.34; 2.95)], and 18.0% vs 5.5% presented with complete remission of cough [RR: 2.91 )95% CI: 1.26; 6.72)]. In adults with AB, 88.7% of participants in the EPs 7630 group and 47.6% in the placebo group showed a ≥50% response for cough intensity [RR: 2.13 (95% CI: 1.37; 3.31)], while 26.0% vs 6.3% did not cough any more at day 7 [RR: 5.00 [95% CI: 3.10; 8.07)]. Cough scale results were supported by significant improvements over placebo in the pursuit of normal daily activities and other QoL measures. In CC, 56.8% of participants treated with EPs 7630 and 38.8% treated with placebo showed a ≥50% cough intensity reduction [RR: 1.40 (95% CI: 1.19; 1.65)] at day 5, while 26.1% versus 18.4% showed complete remission of cough for EPs 7630 and placebo, respectively [RR: 1.40 (95% CI: 1.06; 1.84)]. CC-associated pain/discomfort and an impairment of usual activities were no longer present in 41.5% and 48.8% of participants treated with EPs 7630 compared to less than 40% of patients in the placebo group. Conclusions: The results show that EPs 7630 reduces the burden and leads to earlier remission of cough. Advantages for EPs 7630 were also reflected in self-rated measures of disease-associated QoL. Of note, patients treated with the herbal product felt able to resume their usual daily activities sooner.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Effects of <em>Pelargonium sidoides</em> extract EPs 7630 on acute cough and quality of life – a meta-analysis of randomized, placebo-controlled trials
- Date Crossref
- 03/08/2022
- Éditeur
- Mattioli1885
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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German Red Cross pays non établi dans la noticeÉtablissement de santé
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Red Cross Hospital pays non établi dans la noticeÉtablissement de santé
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University of Cologne Emeritus pays non établi dans la noticeUniversité ou école supérieure
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Dr Willmar Schwabe (Germany) pays non établi dans la noticeEntreprise
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University Medical Center Freiburg pays non établi dans la noticeÉtablissement de santé
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Evangelisches Krankenhaus Hamm pays non établi dans la noticeÉtablissement de santé
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Pomeranian Medical University pays non établi dans la noticeUniversité ou école supérieure
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Respiratory and Sleep Medicine at Red Cross Maingau Hospital Group Practice and Centre Allergy pays non établi dans la noticeÉtablissement de santé
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Dr. Willmar Schwabe GmbH & Co. KG Research & Development Department pays non établi dans la noticeEntreprise
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University Hospital Freiburg Department of Pneumology pays non établi dans la noticeUniversité ou école supérieure
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Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
German Red Cross, Red Cross Hospital et Emeritus — University of Cologne, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.