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2022
article
Economic Evaluation of Using Daily Prednisolone versus Placebo at the Time of an Upper Respiratory Tract Infection for the Management of Children with Steroid-Sensitive Nephrotic Syndrome: A Model-Based Analysis
Nafsika Afentou, Emma Frew, Samir Mehta, Natalie Ives, Rebecca Woolley, Elizabeth Brettell, Adam Khan, David V. Milford, Detlef Böckenhauer, Moin A. Saleem, Angela Hall, Ania Koziell, Heather Maxwell, Shivaram Hegde, Eric Finlay, Rodney D. Gilbert, Caroline Jones, Karl McKeever, Wendy L. Cook, Nicholas J.A. Webb, Martin Christian, Emma Barsoum, Helen Bodenham-Chilton, Noreen Akhtar, C. David Hunt, Carla Galinha, Dominique R. Smith, Neil Winkles, Catherine A Moakes, Sandra Cope, Megan Thomas, N. Coad, Darren Green, Kate Hillman, Zala Ibrahim, Ly‐Mee Yu, A. MacDonald Watson, Fatima Bibi Team, Eduardo Moya, Alison Kelly, Eilean Crosbie, Rachel Swingler, Susan Kilroy Team, Oyekunle Ayonrinde, Amanda Smith, Andrea Turner, Jonathan D. Campbell, Aine Turner, Stephen Brearey, Caroline Burchett, Sarah De-Beger, Theo Fenton, Glyn Jones, Nicci Kelsall, Selwyn D’Costa, Dinakaran Jayachandran, Asha Nair Catherine Tarn Nozedar, Dawn Egginton, Oliver Cuthell, Catherine Derry, K. Natesan, Sarah-Jane Sharman, Rajeeva Singh, Kathryn Deakin, Gail Castle Team, Bukar Wobi, Bemigho Etuwewe, Caroline Burnett & Team, Kamal Khoobarry, Graham Whincup, Anne Cowley, Manish D. Sinha, Christopher M. Reid, Mohammad Ahmad Team, B Padmakumar, Talaivirichan Magadevan, Gráinne O’Connor, Louise Woodhead, Mireille Formosa, Nayan Peepah Nardeosingh, Kathryn Allison, Markus Hesseling, Annette Bolger, Lucie Hobson Team, Adamu Sambo, Lyda Jadresić, Susan Beames, Daljit K. Hothi, Elizabeth J. Vella, Corinne Linton, Shaima Yussuf, Tendai Bazaya, Mahmoud Abou-Rayyah Team, Nick West, Rajiv Sood, Hilarious De Jesus Team, Vikas Gupta, Verghese Mathew, Esi Bentsi-Enchill, Allyson Davison, Janet Craze, Elhussein Rfidah, Janine Musselwhite, Angela Moon Team, Harsha Bilolikar, Sonia White Team, Simon J. Rhodes, Caroline Moulds, Hitesh Prajapati, Pallavi Yadav, Amanda Newnham, Kay Tyerman, Majorie Allen, Lucy Wellings Team, Jackie Philps Team, Subajini Kaviethasan, Sally Smith Team, David Broodbank, Sourabh Mukhopadhyay, Ruchika Gupta, Amanda Roper, Susie Butler Team, Tomasz Rajkowski, Michael Eisenhut, Karen Duncan, Karen Samm, Samantha Clough Team, David Wright, Krishnakumar Thattakkat, Ignatius Losa, Natalie Keenan Team, K. Balasubramanian, Muhammad Javed, Sharon Kempson, Marie Phipps Team, Janette Cansick, Maines Msiska, Lazarus Anguvaa, Mya Mya Aye, Sally Conway, Natalie Beer, Francesca Wright Team, Jennifer Langlands, Kirsty O’Brien, Nicola Thorne Team, Karen Davies, Ami Parikh, Nimze Gadong, B Anjum, Nicolene Plaatjies, Ivone Lancoma-Malcolm, Vipan Datta, Chris Upton, Louisa Fear, Louise Coke Team, Dermot Dalton, Becky Holbrook Team, Imogen Norton, Andrew Lunn, Olivia Vincent, Helen Navarra, Neelam Khan Team, Mona Aslam, Paula Goodyear, Steve Wadams, Susan Power, Amy Roff Team, Manish Gupta, Naeem Ayub, Charlotte Owen Team, Judith Scanlan, Sharon McCready, Andrew Gribbin, Mansoor Ahmed, Dominic Muogbo, Heather Carswell, Stephanie Boswell, Claire Backhouse Team, Junaid O. Solebo, Helen Smith, Alan T. Webb, Ing-Marie Logie, Sandra Dekker, Sanjay Suri, Janet Shackleton Team, Craig Oxley, Margaret Connon Team, Vineeta Joshi, Nicola Pemberton Team, Amita Sharma, Elizabeth Waxman Team, Muriel Millar Team, Ann Gordon, Susan Edees, Susan Hallett Team, Javed Iqbal, Beate von Bremen, Heather Collier, Andrew Lancaster Team, Fiona Watson, Joanne Henry Team, Richard Bowker, Coral Smith, Hannah Cottis, Rebecca Samuel, Caroline Harrill, Suzanne Wilkins Team, B. C. Reynolds, David Hughes, Elizabeth Elizabeth, Waxman Team, Tracey McGregor, Maxine Ramsay, Julie Baggott, Naomi Matos Team, Henry Morgan, Richard Holt, Louise Oni Theresa Moorcroft, Joanne Shakeshaft Team, Mohan Shenoy, Amrit Kaur, Dean Wallace, Plant Nd, Shaila Sukthankar, Angela Branson, Helen Blackburn, Jane Howell, Jess Nichols Team, Furqan Basharat, S Senthil Raja, Marie Phipps, Helen Parker, Joanne Tomlinson, Eric Roe Team, Lynn Diskin, Alison Barratt, Subramanian Mahadevan-Bava, Abigail F. Weston, Daljit Kaur, Udupa Venkatesh, Temlett Emma, Simon Dyer, Kerry Elliott, Rosie Furness Team, Janet Shackleton, Sarah Shortland, Miranda Murray Team, Matthew Harmer, Shuman Haq, Lisa Fairhead, Louise Haskell, Victoria Team, Anupam Shrivastava, Onie Hove, Bernard Hadebe, Christopher Magier, Bettina Harms, Sian Butterworth, Tariq M. Bhatti, A. Parker, Lorna Walding Team, Nicholas Brennan, Chris Cooper, Sara Bennett Team, Anjali Date, Anjali Petkar, Wendy Hulse Team, M. Daud Ahmed, Tom Dawson, Connie S. Chamberlain, Simon Meyrick, Iain Darwood, Emma Collins, Rajesh Lall, E U Onifade, Joanna Green Team, Sally Johnson, H Lambert, Yincent Tse, Michal Malina, Vijaya Sathyanarayan, J. G. Booth, Kathryn Bell, Stephen Crulley Team, Jackie Buck, Deborah Beeby, Louise Hunt Team, Sundeep Sandhu, Gur Millman, Murray Wheeler, Anna Marie Clayton, David Thompson Team, Bridget Oates, Claire L. Bell, Joanna Wardrop Team, Vijay Tandle, Carolyn Campbell, Dawn Egginton Team, Rajesh Krishnan, Zoë Morrison, Jennifer Muller, Louise Yendle Team, Delyth Webb, Natalie Rogers, Nour Elhadi, Dipali Shah, Amrinder Sayan Team, Karine Cesar, Raman Lakshman, Helen Cockerill, Zilla Huma, Thin Thin Saing, Angela Brown, Karen Leitch Team, Gopi Vemuri, Claire Holliday, Jessica Carey, Louise Woodhead TeamMadalitso Kubwalo, Annette Bolger Team
1Citations signalées — pas une note de qualité
20Institutions déclarées
1Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: Childhood steroid-sensitive nephrotic syndrome is a frequently relapsing disease with significant short- and long-term complications, leading to high healthcare costs and reduced quality of life for patients. The majority of relapses are triggered by upper respiratory tract infections (URTIs) and evidence shows that daily low-dose prednisolone at the time of infection may reduce the risk of relapse. OBJECTIVE: The aim of this study was to assess the cost effectiveness of a 6-day course of low-dose prednisolone at the start of a URTI when compared with placebo. METHODS: A state-transition Markov model was developed to conduct a cost-utility analysis with the outcome measured in quality-adjusted life-years (QALYs). Resource use and outcome data were derived from the PREDNOS2 trial. The analysis was performed from a UK National Health Service perspective and the results were extrapolated to adulthood. Model parameter and structural uncertainty were assessed using sensitivity analyses. RESULTS: The base-case results showed that administering low-dose prednisolone at the time of a URTI generated more QALYs and a lower mean cost at 1 year compared with placebo. In the long-term, low-dose prednisolone was associated with a cost saving (£176) and increased effectiveness (0.01 QALYs) compared with placebo and thus remained the dominant treatment option. These findings were robust to all sensitivity analyses. CONCLUSION: A 6-day course of low-dose prednisolone at the time of a URTI in children with steroid-sensitive nephrotic syndrome has the potential to reduce healthcare costs and improve quality of life compared with placebo.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Economic Evaluation of Using Daily Prednisolone versus Placebo at the Time of an Upper Respiratory Tract Infection for the Management of Children with Steroid-Sensitive Nephrotic Syndrome: A Model-Based Analysis
- Date Crossref
- 22/06/2022
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Renal Diseases and GlomerulopathiesSystemic Lupus Erythematosus ResearchThyroid Disorders and Treatments