Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients. METHODS: We compared demographics, clinical characteristics, and outcomes of US children (aged 8 months to 17 years) admitted to the intensive care or high-acuity unit with influenza or COVID-19. Using mixed-effects models, we assessed the odds of death or requiring life support for influenza vs COVID-19 after adjustment for age, sex, race and Hispanic origin, and underlying conditions including obesity. RESULTS: Children with influenza (n = 179) were younger than those with COVID-19 (n = 381; median, 5.2 years vs 13.8 years), less likely to be non-Hispanic Black (14.5% vs 27.6%) or Hispanic (24.0% vs 36.2%), and less likely to have ≥1 underlying condition (66.4% vs 78.5%) or be obese (21.4% vs 42.2%), and a shorter hospital stay (median, 5 days vs 7 days). They were similarly likely to require invasive mechanical ventilation (both 30.2%), vasopressor support (19.6% and 19.9%), or extracorporeal membrane oxygenation (2.2% and 2.9%). Four children with influenza (2.2%) and 11 children with COVID-19 (2.9%) died. The odds of death or requiring life support in children with influenza vs COVID-19 were similar (adjusted odds ratio, 1.30; 95% confidence interval, .78-2.15; P = .32). CONCLUSIONS: Despite differences in demographics and clinical characteristics of children with influenza or COVID-19, the frequency of life-threatening complications was similar. Our findings highlight the importance of implementing prevention measures to reduce transmission and disease severity of influenza and COVID-19.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
- Date Crossref
- 15/07/2022
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Vanderbilt University Medical Center Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Boston Children's Hospital Department of Anesthesiology pays non établi dans la noticeÉtablissement de santé
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Centers for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Mayo Clinic in Florida Department of Pediatric and Adolescent Medicine pays non établi dans la noticeÉtablissement de santé
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New York University Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Children's Hospital of Philadelphia pays non établi dans la noticeOrganisme public
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University of Pennsylvania Department of Anesthesiology and Critical Care pays non établi dans la noticeUniversité ou école supérieure
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Philadelphia University pays non établi dans la noticeUniversité ou école supérieure
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Medical University of South Carolina Division of Pediatric Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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Children's Hospital Colorado Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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University of Colorado Denver pays non établi dans la noticeUniversité ou école supérieure
Department of Pediatrics — Vanderbilt University Medical Center, Department of Anesthesiology — Boston Children's Hospital et Centers for Disease Control and Prevention, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.