Correlation Between Choroidal Structure and Smoking in Eyes With Central Serous Chorioretinopathy

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Abstract A smoking habit is associated with central serous chorioretinopathy (CSC). Although CSC is caused by an abnormal circulation of the choroid, how smoking habit affects the choroid remains elusive. Therefore, to investigate the effect of smoking on the choroidal structure in patients with CSC, the current study analyzed two important choroidal morphological parameters in 75 consecutive CSC patients with/without a smoking habit; i.e., subfoveal choroidal thickness [SFCT] and the choroidal vascular index (CVI), the ratio of the luminal area to the total choroidal area. The results demonstrated that although other baseline parameters (age or refractive error expressed by the spherical equivalent [SE]) was not different between the smoking group and the non-smoking group, the SFCT was thicker in smoking group compared with non-smoking group (382.0 ± 68.2 μm vs. 339.3 ± 52.3 μm, p = 0.0038). No significant difference was observed in the CVI (p = 0.32). The optimal model for SFCT included the variables of age, SE and a history of smoking among the baseline parameters. Additionally, increased pack years was associated with increased SFCT. Taken together, cigarette smoking is associated with an increased SFCT in patients with CSC. Thicker choroid in smoking CSC patients may be an important modulator of the disease.

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