Kazuaki Kadonosono

Protocol for the SACLA trial: Efficacy and safety of subretinal monteplase for submacular hemorrhage in a phase II single-arm multicenter decentralized clinical trial

Noriko Yoshida, Yuko Kobayakawa, Kouta Funakoshi, Sakiko Kimura et autres

Submacular hemorrhage (SMH), which may arise from age-related macular degeneration, retinal arterial macroaneurysm, and other causes, can result in severe vision loss and central visual field impairment. Although tissue plasminogen activator (tPA) is used off-label to treat SMH in many countries, no …

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SURGICAL MANAGEMENT AND OUTCOMES OF LARGE HIGH MYOPIC MACULAR HOLES

Tianyu Liu, Nassim A. Abreu-Arbaje, Joana Andoh, J Fernando Arevalo et autres

PURPOSE: To characterize the surgical management and outcomes of large high myopic macular holes (HMMHs). METHODS: Global multicenter retrospective case series of HMMHs with minimum linear diameter ≥ 400 µ m undergoing surgery between 2013 and 2023 with follow-up ≥ 3 months. …

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Minimally Invasive Subretinal Perfluorocarbon Liquid (PFCL) Removal

Jared Ching, Shin Tanaka, Kitahata Shohei, Kazuaki Kadonosono

Purpose: Perfluorocarbon liquid (PFCL) is widely used in retinal surgery; however, it can be complicated by subretinal retention that can affect/threaten fovea. A number of different approaches have been explored to remove retained PFCL. Here, we investigate the use of microneedles with …

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Investigating the feasibility of selective anti-VEGF delivery to the retina using a microinvasive approach

Jared Ching, Mizuho Arai, Mayu Ooba, Misa Miyazato et autres

BACKGROUND: Retinal therapeutics has been revolutionized by anti-vascular endothelial growth factor (VEGF) therapies, whereby intravitreal injection is the accepted delivery method. To date, the possibility of direct surgical delivery to the subretinal space or an endovascular approach has yet to be explored. …

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Embolus Migration and Reperfusion in Central Retinal Artery Occlusion Treated by Intra-Arterial Cannulation

Maiko Maruyama-Inoue, Kazuaki Kadonosono

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Investigating Microinvasive Intra‐Ocular Biopsy

Jared Ching, Shohei Kitahata, Hinako Ichikawa, Kazuaki Kadonosono

BACKGROUND: Current minimally invasive methods of intraocular biopsy are confined to small gauge (G) needles and subretinal cannulae that can be prone to wound leakage at the biopsy site. We investigate the role of microneedles with internal diameters as small as 49G …

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Prediction of central visual field deterioration by sector-wise peripapillary vessel density measurement in eyes with retinitis pigmentosa

Kazuyoshi Ôkawa, Yume Iwashita, Tatsuya Inoue, Shohei Kawasaki et autres

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One-Year Outcomes of Intravitreal Faricimab Injection in Treatment-Naïve Patients With Neovascular Age-Related Macular Degeneration

Kazuyoshi Ôkawa, Maiko Maruyama-Inoue, Jacob Yuhang Chin, Tatsuya Inoue et autres

Purpose: To investigate the 1-year functional and morphologic outcomes of intravitreal (IVT) faricimab in treatment-naïve Japanese patients with neovascular age-related macular degeneration (nAMD). Methods: A retrospective study was performed to examine the outcomes of patients with nAMD who received IVT faricimab using …

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Association of vessel density with retinal sensitivity in patients with branch retinal artery occlusion

Rei Arasaki, Jacob Yuhang Chin, Tatsuya Inoue, Ryo Asaoka et autres

PURPOSE: To investigate the relationship between vessel density and retinal sensitivity in patients with branch retinal artery occlusion (BRAO). METHODS: This was a retrospective study of fourteen eyes of 13 BRAO patients. MP-3 microperimeter measurement and OCTA exams were performed at the …

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Outcomes of glaucoma tube shunt implantation with vitrectomy in eyes with neovascular glaucoma

Shiro Katsube, Tatsuya Inoue, Shinobu Kobayashi, Jacob Yuhang Chin et autres

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Real-World Outcomes of Brolucizumab Treatment in Japanese Patients with Neovascular Age-Related Macular Degeneration: A 12-Month, Multicenter Study

Masayuki Ohnaka, Yoichi Sakurada, Atsushi Hayashi, Kazuaki Kadonosono et autres

INTRODUCTION: The aim of this study was to evaluate the real-world outcomes of brolucizumab use in Japanese patients with neovascular age-related macular degeneration (nAMD). METHODS: PHEASANT was a retrospective, multicenter, single-arm cohort study. The study included 438 patients, of whom 123 were …

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Macular retinal function after autologous retinal transplantation in patients with refractory macular holes

Rei Arasaki, Tatsuya Inoue, Hiroko Terasaki, Shinji Ueno et autres

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