Retrospective Analysis of Testicular Germ Cell Tumor Patients with Brain Metastases: A Single-Center Experience

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Germ cell tumors (GCTs) are especially common in men between the ages of 20 and 40 years. 1 Generally, surgery and, when necessary, systemic chemotherapy are performed for treatment.It is a chemosensitive tumor.Owing to effective systemic treatment protocols, especially cisplatin-based chemotherapy protocols, successful clinical results can often be obtained even in the advanced stage. 2 Longterm remission can be achieved with high-dose chemotherapy (HDC) in relapsing or refractory GCTs. 3 The poor risk criteria recommended by the International Germ Cell Cancer Collaborative Group (IGCCCG) are used to define the group with a generally poor prognosis of GCTs.Poor risk criteria include elevated serum tumor markers and the presence of mediastinal primary and non-pulmonary metastases.4 Regardless of whether it is detected as synchronous at diagnosis or metachronous at relapse, brain metastasis (BM) is a rare clinical condition among non-pulmonary visceral metastases and has a poor prognosis even when detected alone.5 Management in cases with BM is often controversial.Retrospective case studies on this subject generally do not report significant endpoints and descriptive results.The combination of surgery, radiotherapy, and systemic chemotherapy is often required in cases of GCTs with BM.However, the effectiveness of these treatment approaches differs among patients due to clinical and radiological characteristics.27

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