The potential of fecal microbiota and amino acids to detect and monitor patients with adenoma
Rattachement africain : ca, nl, gb, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The risk of recurrent dysplastic colonic lesions is increased following polypectomy. Yield of endoscopic surveillance after adenoma removal is low, while interval colorectal cancers occur. To longitudinally assess the dynamics of fecal microbiota and amino acids in the presence of adenomatous lesions and after their endoscopic removal. In this longitudinal case–control study, patients collected fecal samples prior to bowel preparation before scheduled colonoscopy and 3 months after this intervention. Based on colonoscopy outcomes, patients with advanced adenomas and nonadvanced adenomas (0.5–1.0 cm) who underwent polypectomy during endoscopy (n = 19) were strictly matched on age, body-mass index, and smoking habits to controls without endoscopic abnormalities (n = 19). Microbial taxa were measured by 16S RNA sequencing, and amino acids (AA) were measured by high-performance liquid chromatography (HPLC). Adenoma patients were discriminated from controls based on AA and microbial composition. Levels of proline (p = .001), ornithine (p = .02) and serine (p = .02) were increased in adenoma patients compared to controls but decreased to resemble those of controls after adenoma removal. These AAs were combined as a potential adenoma-specific panel (AUC 0.79(0.64–0.94)). For bacterial taxa, differences between patients with adenomas and controls were found (Bifidobacterium spp.↓, Anaerostipes spp.↓, Butyricimonas spp.↑, Faecalitalea spp.↑ and Catenibacterium spp.↑), but no alterations in relative abundance were observed after polypectomy. Furthermore, Faecalitalea spp. and Butyricimonas spp. were significantly correlated with adenoma-specific amino acids. We selected an amino acid panel specifically increased in the presence of adenomas and a microbial signature present in adenoma patients, irrespective of polypectomy. Upon validation, these panels may improve the effectiveness of the surveillance program by detection of high-risk individuals and determination of surveillance endoscopy timing, leading to less unnecessary endoscopies and less interval cancer.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The potential of fecal microbiota and amino acids to detect and monitor patients with adenoma
- Date Crossref
- 21/02/2022
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Institute of Aging pays non établi dans la noticeStructure de recherche
-
Amsterdam UMC Location Vrije Universiteit Amsterdam pays non établi dans la noticeÉtablissement de santé
-
University Hospitals Birmingham NHS Foundation Trust Institute of Translational Medicine pays non établi dans la noticeÉtablissement de santé
-
NIHR Surgical Reconstruction and Microbiology Research Centre pays non établi dans la noticeStructure de recherche
-
Center for Genomic Science pays non établi dans la noticeStructure de recherche
-
University of Birmingham Institute of Cancer and Genomic Sciences pays non établi dans la noticeUniversité ou école supérieure
-
NIHR Birmingham Biomedical Research Centre pays non établi dans la noticeStructure de recherche
-
Spaarne Ziekenhuis pays non établi dans la noticeÉtablissement de santé
-
Spaarne Gasthuis Department of Gastroenterology and Hepatology pays non établi dans la noticeÉtablissement de santé
-
OLVG pays non établi dans la noticeÉtablissement de santé
-
National Institute for Health and Care Research pays non établi dans la noticeOrganisme public
-
Health Data Research UK pays non établi dans la noticeOrganisation à but non lucratif
Institute of Aging, Amsterdam UMC Location Vrije Universiteit Amsterdam et Institute of Translational Medicine — University Hospitals Birmingham NHS Foundation Trust, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.