Elevated intraocular pressure in children with acute lymphoblastic leukaemia: A prospective study
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Le résumé fourni par la source
Most childhood acute lymphoblastic leukaemia (ALL) protocols include high-dose steroid therapy. However, the known potential of high-dose steroids to significantly elevate intraocular pressure (IOP) and lead to glaucomatous optic neuropathy has not been intensively investigated in children with ALL. Moreover, as children with ALL do not routinely undergo IOP measurements, the need for IOP monitoring and therapy is unknown. We prospectively measured IOP in 90 children with newly diagnosed ALL attending a tertiary paediatric haematology/oncology centre, at diagnosis and at the middle and end of induction therapy. Ocular hypertension (IOP > 21 mm Hg) at any time point was documented in 64 children (71%), and the prevalence increased during induction. Thirty-six children (40%) had elevated IOP at ALL diagnosis before therapy initiation, and stratification to non-standard ALL was a risk factor. IOP reduction therapy was administered to 13 children (14%); none required surgery. Values normalised in all cases. On multivariate logistic regression analysis, dexamethasone therapy was a significant risk factor for ocular hypertension. High body mass index was an additional risk factor in children with elevated IOP at ALL diagnosis. Routine evaluation of IOP during steroid therapy is very important in children with ALL to ensure early intervention which may prevent permanent ocular damage.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Elevated intraocular pressure in children with acute lymphoblastic leukaemia: A prospective study
- Date Crossref
- 04/12/2021
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tel Aviv University pays non établi dans la noticeUniversité ou école supérieure
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Schneider Children's Medical Center Department of Pediatric Hematology-Oncology pays non établi dans la noticeÉtablissement de santé
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Hebrew University of Jerusalem Department of Statistics and Data Science pays non établi dans la noticeUniversité ou école supérieure
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Rabin Medical Center Department of Ophthalmology pays non établi dans la noticeÉtablissement de santé
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Sackler Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Department of Statistics and Data Science Hebrew University Jerusalem Israel pays non établi dans la noticeUniversité ou école supérieure
Tel Aviv University, Department of Pediatric Hematology-Oncology — Schneider Children's Medical Center et Department of Statistics and Data Science — Hebrew University of Jerusalem, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.