Measuring adherence to antihypertensive medication using an objective test in older adults attending primary care: cross-sectional study
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Le résumé fourni par la source
Analysis of urine samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS) has previously revealed high rates of non-adherence to antihypertensive medication. It is unclear whether these rates represent those in the general population. This study aimed to investigate whether it is feasible to collect urine samples in a primary care setting and analyse them using LC-MS/MS to detect non-adherence to antihypertensive medication. This study used a prospective, observational cohort design. Consecutive patients were recruited opportunistically from five general practices in UK primary care. They were aged ≥65 years with hypertension and had at least one antihypertensive prescription. Participants were asked to provide a urine sample for analysis of medication adherence. Samples were sent to a laboratory via post and analysed using LC-MS/MS. Predictors of adherence to medication were explored with multivariable logistic regression. Of 349 consecutive patients approached for the study, 214 (61.3%) gave informed consent and 191 (54.7%) provided a valid urine sample for analysis. Participants were aged 76.2 ± 6.6 years and taking a median of 2 antihypertensive medications (IQR 1-3). A total of 27/191 participants (14.2%) reported not taking all of their medications on the day of urine sample collection. However, LC-MS/MS analysis of samples revealed only 4/27 (9/191 in total; 4.7%) were non-adherent to some of their medications. Patients prescribed more antihypertensive medications were less likely to be adherent (OR 0.24, 95%CI 0.09-0.65). Biochemical testing for antihypertensive medication adherence is feasible in routine primary care, although non-adherence to medication is generally low, and therefore widespread testing is not indicated.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Measuring adherence to antihypertensive medication using an objective test in older adults attending primary care: cross-sectional study
- Date Crossref
- 07/12/2021
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Oxford Nuffield Department of Primary Care Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Leicester Department of Cardiovascular Sciences pays non établi dans la noticeUniversité ou école supérieure
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University Hospitals of Leicester NHS Trust Department of Chemical Pathology and Metabolic Diseases pays non établi dans la noticeÉtablissement de santé
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University of Birmingham pays non établi dans la noticeUniversité ou école supérieure
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College of Medical and Dental Sciences Birmingham Medical School pays non établi dans la noticeUniversité ou école supérieure
Nuffield Department of Primary Care Health Sciences — University of Oxford, Department of Cardiovascular Sciences — University of Leicester et Department of Chemical Pathology and Metabolic Diseases — University Hospitals of Leicester NHS Trust, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.