Epigenome-Wide DNA Methylation and Pesticide Use in the Agricultural Lung Health Study
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Le résumé fourni par la source
BACKGROUND: Pesticide exposure is associated with many long-term health outcomes; the potential underlying mechanisms are not well established for most associations. Epigenetic modifications, such as DNA methylation, may contribute. Individual pesticides may be associated with specific DNA methylation patterns but no epigenome-wide association study (EWAS) has evaluated methylation in relation to individual pesticides. OBJECTIVES: We conducted an EWAS of DNA methylation in relation to several pesticide active ingredients. METHODS: The Agricultural Lung Health Study is a case-control study of asthma, nested within the Agricultural Health Study. We analyzed blood DNA methylation measured using Illumina's EPIC array in 1,170 male farmers of European ancestry. For pesticides still on the market at blood collection (2009-2013), we evaluated nine active ingredients for which at least 30 participants reported past and current (within the last 12 months) use, as well as seven banned organochlorines with at least 30 participants reporting past use. We used robust linear regression to compare methylation at individual C-phosphate-G sites (CpGs) among users of a specific pesticide to never users. RESULTS: -gene expression, supporting functional effects of findings. We corroborated a previously reported association between dichlorodiphenyltrichloroethane (banned in the United States in 1972) and epigenetic age acceleration. DISCUSSION: We identified differential methylation for several active ingredients in male farmers of European ancestry. These may serve as biomarkers of chronic exposure and could inform mechanisms of long-term health outcomes from pesticide exposure. https://doi.org/10.1289/EHP8928.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Epigenome-Wide DNA Methylation and Pesticide Use in the Agricultural Lung Health Study
- Date Crossref
- 01/09/2021
- Éditeur
- American Chemical Society (ACS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Institutes of Health pays non établi dans la noticeOrganisme public
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National Institute of Environmental Health Sciences Epidemiology Branch pays non établi dans la noticeStructure de recherche
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University Medical Center Groningen Department of Pediatric Pulmonology and Pediatric Allergy pays non établi dans la noticeÉtablissement de santé
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University of Groningen pays non établi dans la noticeUniversité ou école supérieure
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University of California Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Westat (United States) pays non établi dans la noticeEntreprise
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United States Department of Health and Human Services pays non établi dans la noticeOrganisme public
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National Cancer Institute Occupational and Environmental Epidemiology Branch pays non établi dans la noticeOrganisme public
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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Radboud University Medical Center Department of Internal Medicine pays non établi dans la noticeOrganisme public
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Medizinische Hochschule Hannover pays non établi dans la noticeUniversité ou école supérieure
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Helmholtz Centre for Infection Research pays non établi dans la noticeStructure de recherche
National Institutes of Health, Epidemiology Branch — National Institute of Environmental Health Sciences et Department of Pediatric Pulmonology and Pediatric Allergy — University Medical Center Groningen, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.