Arm Based on LEg blood pressures (ABLE-BP): can systolic leg blood pressure measurements predict systolic brachial blood pressure? Protocol for an individual participant data meta-analysis from the INTERPRESS-IPD Collaboration
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Le résumé fourni par la source
INTRODUCTION: Blood pressure (BP) is normally measured on the upper arm, and guidelines for the diagnosis and treatment of high BP are based on such measurements. Leg BP measurement can be an alternative when brachial BP measurement is impractical, due to injury or disability. Limited data exist to guide interpretation of leg BP values for hypertension management; study-level systematic review findings suggest that systolic BP (SBP) is 17 mm Hg higher in the leg than the arm. However, uncertainty remains about the applicability of this figure in clinical practice due to substantial heterogeneity. AIMS: To examine the relationship between arm and leg SBP, develop and validate a multivariable model predicting arm SBP from leg SBP and investigate the prognostic association between leg SBP and cardiovascular disease and mortality. METHODS AND ANALYSIS: Individual participant data (IPD) meta-analyses using arm and leg SBP measurements for 33 710 individuals from 14 studies within the Inter-arm blood pressure difference IPD (INTERPRESS-IPD) Collaboration. We will explore cross-sectional relationships between arm and leg SBP using hierarchical linear regression with participants nested by study, in multivariable models. Prognostic models will be derived for all-cause and cardiovascular mortality and cardiovascular events. ETHICS AND DISSEMINATION: Data originate from studies with prior ethical approval and consent, and data sharing agreements are in place-no further approvals are required to undertake the secondary analyses proposed in this protocol. Findings will be published in peer-reviewed journal articles and presented at conferences. A comprehensive dissemination strategy is in place, integrated with patient and public involvement. PROSPERO REGISTRATION NUMBER: CRD42015031227.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Arm Based on LEg blood pressures (ABLE-BP): can systolic leg blood pressure measurements predict systolic brachial blood pressure? Protocol for an individual participant data meta-analysis from the INTERPRESS-IPD Collaboration
- Date Crossref
- 01/03/2021
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Exeter Primary Care Research Group pays non établi dans la noticeUniversité ou école supérieure
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University of Oxford Nuffield Department of Primary Care Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Stockport NHS Foundation Trust Department of Cardiology pays non établi dans la noticeÉtablissement de santé
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Royal National Orthopaedic Hospital pays non établi dans la noticeÉtablissement de santé
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University College London pays non établi dans la noticeUniversité ou école supérieure
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University of Birmingham Institute of Clinical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Centre Hospitalier Universitaire de Limoges Department of Cardiology pays non établi dans la noticeÉtablissement de santé
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Exeter Primary Care pays non établi dans la noticeÉtablissement de santé
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Patient and Public Involvement Advisor pays non établi dans la noticeInstitution
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Mid Devon Medical Practice pays non établi dans la noticeInstitution
Primary Care Research Group — University of Exeter, Nuffield Department of Primary Care Health Sciences — University of Oxford et Department of Cardiology — Stockport NHS Foundation Trust, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.