Relationship between spectral analysis, SUV and SUV Pons ratio as a measure of cerebral glucose metabolic rate in Alzheimer's disease
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Le résumé fourni par la source
Abstract Background Cerebral metabolic rate of glucose (CMRglc) can be measured with fluorodeoxyglucose (FDG) positron emission tomography (PET) using arterial blood sampling. However, blood sampling is an invasive methodology for subjects. Standard uptake value (SUV) is a non‐invasive method to assess the cerebral glucose metabolism. Here we evaluate the relationship between semi‐quantitative measurements such as SUV and Pons ratio with a quantitative measurement such as Spectral analysis (SA) in order to assess their surrogate use in clinical trials. Methods To assess cerebral glucose metabolism by a non‐invasive and simplified method, the standardized uptake value (SUV) and used the Pons RATIO (where target region was divided by pons as a reference region, which requires no arterial input function or blood sampling. The SA was performed using blood sampling to create the input function. The study participants included 63 subjects (mean ± SD age, 71 ± 8 years) from the Evaluating Liraglutide in Alzheimer’s Disease (ELAD) trial. Regional CMRglucose (CMRglc) and regional SUV were measured using FDG PET, and the correlation between CMRglc and SUV together with CMRglc and Pons ratio were estimated for the temporal lobe, medial temporal lobe and hippocampus Results In this AD population, the SA and SUV in the temporal lobe (r=0.635, p= >0.001), medial temporal lobe (0.533, p= >0.001) and hippocampus (r=0.539, p= >0.001) had a positive correlation and were statistically significant. The correlation coefficient between SA and Pons ratio for the temporal lobe (r=0.166, p= 0.194), medial temporal lobe (r=0.146, p=0.146) and the hippocampus (r=0.193, p=0.129) was positive but not statistically significant. Conclusion The SUV correlated better with cerebral glucose metabolic rate using SA than Pons RATIO in AD subjects, while Pons RATIO did not perform well. Therefore, SUV analysis maybe more reliable analysis method compared to Pons RATIO for FDG PET in clinical trials in AD subjects.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Relationship between spectral analysis, SUV and SUV Pons ratio as a measure of cerebral glucose metabolic rate in Alzheimer's disease
- Date Crossref
- 01/12/2020
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Imperial College London pays non établi dans la noticeUniversité ou école supérieure
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University College London Institute of Cognitive Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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University of Southampton pays non établi dans la noticeUniversité ou école supérieure
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University of Edinburgh Centre for Clinical Brain Sciences pays non établi dans la noticeUniversité ou école supérieure
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South West London and St George's Mental Health NHS Trust pays non établi dans la noticeÉtablissement de santé
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Southern Health NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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Heart of England NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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UK Dementia Research Institute pays non établi dans la noticeStructure de recherche
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UCL Queen Square Institute of Neurology pays non établi dans la noticeUniversité ou école supérieure
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King's College London pays non établi dans la noticeUniversité ou école supérieure
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St. Margaret's Hospital Mental Health Unit pays non établi dans la noticeÉtablissement de santé
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North Bristol NHS Trust pays non établi dans la noticeÉtablissement de santé
Imperial College London, Institute of Cognitive Neuroscience — University College London et University of Southampton, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.