Aparna Prasanna

VTE Risk Assessment Compliance in Older Adult Psychiatric Inpatients

Tegan Deu, Aparna Prasanna

Aims: The aim of this audit is to assess adherence to the local VTE (venous thromboembolism) risk assessment guidelines across inpatient older adult psychiatry care in the Black Country Healthcare NHS Foundation Trust (BCHFT). An update to the National Institute for Health …

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Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial

Paul Edison, Grazia Daniela Femminella, Craig Ritchie, Joseph Nowell et autres

Liraglutide, a glucagon-like peptide 1 (GLP-1) agonist and antidiabetic drug, has shown neuroprotective effects in animal models. In this study, we aimed to evaluate the safety and efficacy of liraglutide in mild to moderate Alzheimer's disease syndrome. 'Evaluating liraglutide in Alzheimer's disease' …

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Do glial‐reactivity and cerebral blood flow modulate cerebral glucose metabolism in Alzheimer’s disease?

Joseph Nowell, Grazia Daniela Femminella, Clive Holmes, Zuzana Walker et autres

Abstract Background Alzheimer’s disease is a devastating neurodegenerative disorder with a complex pathogenesis. One main pathological feature utilised in diagnosis is neurodegeneration or neuronal injury, which is reflected in reductions in cerebral glucose metabolism measured by [18F]Fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET). …

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Prescribing Practice of Citalopram and Escitalopram in Older Adults Following the 2014 MHRA Guidance of Associated QTc Prolongation: A Clinical Audit

Shreyan Kar, Aparna Prasanna

Aims Citalopram and escitalopram are commonly used serotonin-specific reuptake inhibitors (SSRIs) for the treatment of depression and anxiety. These medications are known to cause corrected QT interval (QTc) prolongation, with risks of further arrhythmias. In 2014, the Medicines Healthcare Regulatory Agency (MHRA) …

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Assessment of Compliance With NICE Guidelines on Safety Planning Following Self-Harm in Elderly Patients in a Mental Health Trust

Safyan Tariq, Aparna Prasanna, Ryan Lau

Aims Our aim was to evaluate the extent to which the risk assessment protocol post self-harm incidents for patients aged over 65 at the Black Country Healthcare Trust is aligned with the recommendations set forth in the NICE Guideline (NG225). We specifically …

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MRI CHANGES FOLLOWING TREATMENT OF GLP‐1 ANALOGUE, LIRAGLUTIDE IN ALZHEIMER’S DISEASE

Paul Edison, Grazia Daniela Femminella, Craig Ritchie, Joseph Nowell et autres

Abstract Background Preclinical evidence in transgenic models of Alzheimer’s disease (AD) suggests that liraglutide, a GLP1 analogue, exerts neuroprotective effects by reducing amyloid oligomers, normalising synaptic plasticity and reducing insulin resistance, and increasing the proliferation of neuronal progenitor cells. ELAD is a …

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Magnetic Resonance Spectroscopy metabolites as biomarkers of Alzheimer’s Disease

Joseph Nowell, Megan M. Lacy Young, Grazia Daniela Femminella, Craig Ritchie et autres

Abstract Background Magnetic resonance spectroscopy (MRS) is a non‐invasive method of evaluating metabolite levels in the cerebral cortex. Measurable metabolites can provide markers of neuronal damage, glial activation and, neurotransmission, pathological features of Alzheimer’s disease. Here we sought to establish the effectiveness …

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Dysfunctional cerebral glucose transport in Alzheimer’s Disease

Joseph Nowell, Grazia Daniela Femminella, Craig Ritchie, Clive Holmes et autres

Abstract Background Glucose is the primary energy source required for the homeostatic function of the brain. Glucose transporter 1 (GLUT1) present at the blood‐brain barrier is a key regulator of glucose transport into the brain. Reduced GLUT1 expression is shown to exacerbate …

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P81: Anticholinergic Burden of Patients Assessed by UK Memory Clinics: An Audit

James Hotham, Muhammad Rizwan Asghar, Aparna Prasanna

Objective:It is estimated that there are 55 million people living with dementias globally. With so few effective treatments available for dementias, it is vital that services optimise the management of risk factors for patients to slow their disease progression as much as …

Improving Allergy Status Documentation on Electronic Patient Records- a Trust-Wide In-Patient Quality Improvement Project

Natalie Cook, Aparna Prasanna, Rhea Mathews, Josh Cabada et autres

Aims NICE guideline CG183 states that “both the drug and the description of the reaction must be documented on all forms of prescription and in a patient's medical records”. Black Country Partnership NHS Foundation Trust (BCPNFT) documents allergy status on both paper …

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Re-Audit of Compliance With Standard Operating Procedure for Prescription of Depot Medication Within the Wolverhampton Older Adult Services

Clare Siew Boon Ling, Aparna Prasanna

Aims 1) To re-audit the current practice of depot prescribing within the Wolverhampton Older Adult Enhanced Community Mental Health Teams (ECMHT). 2) To assess whether the implementation of a memory aid for prescribers has improved compliance of current practice to the Black …

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Evaluation of Early Neuro-Imaging Requests for Dementia Diagnosis in Wolverhampton Memory Assessment Service (MAS)

Aparna Prasanna, Kuljit Mandair, Clare Siew Boon Ling

Aims The Wolverhampton Memory Assessment Service (MAS) is nurse led and accepts referrals from primary and secondary care settings. There has been a rapid rise in the number of referrals as well as an increase in demand to provide a timely diagnosis. …

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