Creating an accessible and understandable modelling language for cell-based simulations

Le résumé fourni par la source

The study of morphogenesis has increasingly entailed the use of computer simulations to predict intricate behaviours from these systems, which has led to the development of tools for computational biologists to build their own simulations. However, uptake of these tools by experimental biologists has been slow and concerns remain over the assumptions underlying such tools, which are not readily explicable to a domain expert without prior programming knowledge. To demonstrate how these concerns might be addressed, we propose the creation of a domain-specific language (DSL) of one such simulation, the MemAgent-Spring model (MSM). By designing this DSL around regimented biological concepts identified by observing discussions between experimentalists and modellers, we hope to better understand how the usability and reproducibility of the MSM might be improved, therefore potentially increasing its usage by experimentalists.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.