Cholera and Pancreatic Cholera: Is VIP the Common Pathophysiologic Factor?
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Le résumé fourni par la source
Background: Cholera remains a major global health problem, causing high output diarrhea leading to severe dehydration and shock in developing countries. We aimed to determine whether vasoactive intestinal polypeptide (VIP), the mediator of pancreatic cholera syndrome, has a role in the pathophysiology of human cholera. Methods: We conducted a prospective observational study of cholera cases hospitalized with severe dehydration. Plasma and stool water levels of VIP were measured just after admission, after complete rehydration (3–4 h), at 24 h post-rehydration and at discharge after diarrhea ceased. Results: In total, 23 cholera patients were examined between January and August 2018. The geometric mean of stool VIP (sVIP) and plasma VIP (pVIP) on admission were 207.67 and 8.34 pmol/L, respectively. pVIP values were all within the normal range (</= 30 pcmol/L); however, sVIP levels were very high at all timepoints, though less so just after rehydration. In multivariable GEE models, after adjustment for covariates, sVIP levels were significantly associated with duration of hospitalization (p = 0.026), total stool volume (p = 0.023) as well as stool output in the first 24 h (p = 0.013). Conclusions: The data suggest that VIP, which is released by intestinal nerves, may play an important role in human choleragenesis, and inhibitors of intestinal VIP merit testing for potential therapeutic benefits.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cholera and Pancreatic Cholera: Is VIP the Common Pathophysiologic Factor?
- Date Crossref
- 02/07/2020
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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International Centre for Diarrhoeal Disease Research pays non établi dans la noticeStructure de recherche
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Hammersmith Hospital pays non établi dans la noticeÉtablissement de santé
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North West London Pathology pays non établi dans la noticeÉtablissement de santé
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Imperial College London Hammersmith Hospital pays non établi dans la noticeUniversité ou école supérieure
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Albany Medical Center Hospital pays non établi dans la noticeÉtablissement de santé
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International Centre for Diarrheal Disease Research (icddr pays non établi dans la noticeInstitution
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Albany Medical College Department of Immunology and Microbial Diseases pays non établi dans la noticeUniversité ou école supérieure
International Centre for Diarrhoeal Disease Research, Hammersmith Hospital et North West London Pathology, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.