House dust microbiota in relation to adult asthma and atopy in a US farming population
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Bacterial exposure from house dust has been associated with asthma and atopy in children but whether these relationships are present in adults remains unclear. OBJECTIVE: We sought to examine associations of house dust microbiota with adult asthma, atopy, and hay fever. METHODS: Vacuumed bedroom dust samples from the homes of 879 participants (average age, 62 years) in the Agricultural Lung Health Study, a case-control study of asthma nested within a farming cohort, were subjected to 16S rRNA amplicon sequencing to characterize bacterial communities. We defined current asthma and hay fever using questionnaires and current atopy by blood specific IgE level > 0.70 IU/mL to 1 or more of 10 common allergens. We used linear regression to examine whether overall within-sample bacterial diversity differed by outcome, microbiome regression-based kernel association test to evaluate whether between-sample bacterial community compositions differed by outcome, and analysis of composition of microbiomes to identify differentially abundant bacterial taxa. RESULTS: Overall diversity of bacterial communities in house dust was similar by asthma status but was lower (P < .05) with atopy or hay fever. Many individual bacterial taxa were differentially abundant (false-discovery rate, <0.05) by asthma, atopy, or hay fever. Several taxa from Cyanobacteria, Bacteroidetes, and Fusobacteria were more abundant with asthma, atopy, or hay fever. In contrast, several taxa from Firmicutes were more abundant in homes of individuals with adequately controlled asthma (vs inadequately controlled asthma), individuals without atopy, or individuals without hay fever. CONCLUSIONS: Microbial composition of house dust may influence allergic outcomes in adults.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- House dust microbiota in relation to adult asthma and atopy in a US farming population
- Date Crossref
- 01/03/2021
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Institutes of Health pays non établi dans la noticeOrganisme public
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National Institute of Environmental Health Sciences Epidemiology Branch pays non établi dans la noticeStructure de recherche
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RTI International pays non établi dans la noticeOrganisation à but non lucratif
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Westat (United States) pays non établi dans la noticeEntreprise
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Division of Cancer Epidemiology and Genetics pays non établi dans la noticeStructure de recherche
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University of Iowa Department of Occupational and Environmental Health pays non établi dans la noticeUniversité ou école supérieure
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Triangle pays non établi dans la noticeOrganisation à but non lucratif
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University of North Carolina at Chapel Hill pays non établi dans la noticeUniversité ou école supérieure
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University of Pittsburgh Department of Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Genomics in Public Health and Medicine Center pays non établi dans la noticeInstitution
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National Cancer Institute Division of Cancer Epidemiology and Genetics pays non établi dans la noticeStructure de recherche
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Biostatistics and Computational Biology Branch pays non établi dans la noticeInstitution
National Institutes of Health, Epidemiology Branch — National Institute of Environmental Health Sciences et RTI International, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.