Changes on functional capacity after impact of oncological digestive surgery: Reality in Chilean patients at Clinical Oncology Institute Arturo López Pérez Foundation.

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e16714 Background: Currently Chile does not have a database of functional capacity (FC) in cancer patients. Our purpose is to assess the impact of oncological digestive surgery in FC in Chilean patients at the Clinical Oncology Institute Foundation Arturo López Pérez (FALP) through the 6 minutes walking test (6MWT), which allows objectifying the FC based within the meters walked for 6 minutes by the patient. Methods: It’s a retrospective study of data analysis. The 6MWT was assessed on the day of admission to FALP and discharge. The FC was measured by the distance walked in 6 minutes. Inclusion criteria were male and female candidates for elective oncological digestive surgery from December 2018 - January 2020 and eligible for the 6MWD. We compared the result of the 6MWD baseline admission against an expected reference value according to age, weight and height, and were classified according to whether they were above or below the reference level; their change was also evaluated after surgery, estimated as a percentage of change. Digestive interventions were classified according to site. A P < 0.05 was considered significant. Results: 108 patients were included; the mean age was 57.8 years and the average body mass index (BMI) 26.6. Upon admission 40.7% (N = 44) were above the reference value and 59.3% (N = 64) below it. Regarding the length of hospital stay, we observed an average 8.97 days (Men = 9.96; women = 7.96; P = 0.008). At discharge in 6MWD an average decrease of 149.6 meters (admission = 502.2 mts; Discharge = 352.6 mts.) is seen. At admission, men with age < 40 years (P = 0.031) and subjects with BMI < 30 (P = 0.039) walked a greater distance. There are no significant differences by surgery classification. Regarding the percentage loss of FC, women are more affected (P < 0.001). Conclusions: Based on the results obtained in the 6MWT, we can conclude that the surgery has an impact on patient’s FC. Note that over 50% of patients had a lower value than the base reference. Therefore, we believe it is important to make a multidisciplinary approach at the time of cancer diagnosis to evaluate and optimize the FC baseline before surgery. Clear examples of this approach are the prehabilitation programs. More studies are required in Chilean patients for more conclusive data.

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