Application of amniotic membrane transplantation and autologous conjunctival flap covering on treatment of corneal ulcers

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Corneal ulcer would be sometimes treated with amniotic membrane transplantation (AMT), autologous conjunctival flap (ACF) coverage or keratoplasty except for medication. The application of keratoplasty is restricted by corneal materials. Therefore, AMT and ACF coverage are widely used to heal corneal ulcers. We know that amniotic membrane has no vascular and lymphatic vessels which promotes epithelial regeneration, inhibits inflammation, neovascularization and scar; while conjunctival flap is rich in vascular and lymphatic vessels and could resist infection, provide barrier protection to cornea, also alleviate pains. Both surgical methods can assist in treating with corneal ulcer, that is based on their indications and contraindications, merits or demerits. ACF coverage may be more suitable for treating infective corneal ulcers, however, AMT may be used for non-infective ulcers.(Int Rev Ophthalmol, 2019, 43: 255-259) Key words: amniotic membrane transplantation; autologous conjunctival flap; keratitis; corneal ulcer

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