Multigram Synthesis of BMS-929075, an Allosteric, Palm Site Inhibitor of HCV NS5B Replicase, Involving the Synthesis of a Highly Functionalized Benzofuran through a Telescoped Process

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An efficient scale-up synthesis of 4-fluoro-2-(4-fluorophenyl)- N -methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide ( BMS-929075 ), an allosteric, palm site inhibitor of the HCV NS5B replicase, is described. The highlights of the process involve (a) the copper-mediated, one-pot synthesis of 2-(3-bromo-2-fluoro-6-methoxyphenyl)acetic acid ( 21 ) from regiospecifically lithiated 1-bromo-2-fluoro-4-methoxybenzene ( 13 ) and ethyl 2-bromoacetate ( 18 ); and (b) the formation of the highly functionalized benzofuran core 26 through a chromatography-free, telescoped process that proceeds via acylation and a subsequent concomitant demethylation and Boc deprotection using BBr 3, followed by an acid-catalyzed cyclization from Boc-protected 2-(3-bromo-2-fluoro-6-methoxyphenyl)- N -methylacetamide 23 . This process was applied to the preparation of 110 g of high-quality BMS-929075 to enable preclinical toxicology studies.

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