Role of damage and management in muscle hypertrophy: Different behaviors of muscle stem cells in regeneration and hypertrophy
Rattachement africain : jp, fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Skeletal muscle is a dynamic tissue with two unique abilities; one is its excellent regenerative ability, due to the activity of skeletal muscle-resident stem cells named muscle satellite cells (MuSCs); and the other is the adaptation of myofiber size in response to external stimulation, intrinsic factors, or physical activity, which is known as plasticity. Low physical activity and some disease conditions lead to the reduction of myofiber size, called atrophy, whereas hypertrophy refers to the increase in myofiber size induced by high physical activity or anabolic hormones/drugs. MuSCs are essential for generating new myofibers during regeneration and the increase in new myonuclei during hypertrophy; however, there has been little investigation of the molecular mechanisms underlying MuSC activation, proliferation, and differentiation during hypertrophy compared to those of regeneration. One reason is that 'degenerative damage' to myofibers during muscle injury or upon hypertrophy (especially overloaded muscle) is believed to trigger similar activation/proliferation of MuSCs. However, evidence suggests that degenerative damage of myofibers is not necessary for MuSC activation/proliferation during hypertrophy. When considering MuSC-based therapy for atrophy, including sarcopenia, it will be indispensable to elucidate MuSC behaviors in muscles that exhibit non-degenerative damage, because degenerated myofibers are not present in the atrophied muscles. In this review, we summarize recent findings concerning the relationship between MuSCs and hypertrophy, and discuss what remains to be discovered to inform the development and application of relevant treatments for muscle atrophy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Role of damage and management in muscle hypertrophy: Different behaviors of muscle stem cells in regeneration and hypertrophy
- Date Crossref
- 01/09/2020
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Osaka University of Pharmaceutical Sciences pays non établi dans la noticeUniversité ou école supérieure
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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Waseda University pays non établi dans la noticeUniversité ou école supérieure
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Inserm pays non établi dans la noticeOrganisme public
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Institut Cochin pays non établi dans la noticeStructure de recherche
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Graduate School of Pharmaceutical Sciences Project for Muscle Stem Cell Biology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Sport Sciences pays non établi dans la noticeUniversité ou école supérieure
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Institut National de la Santé et de la Recherche Médicale U1016 pays non établi dans la noticeStructure de recherche
Osaka University of Pharmaceutical Sciences, The University of Osaka et Waseda University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.