Accès ouvert déclaré2020article
Infective Endocarditis Related to Unusual Microorganisms: A Prospective Population-Based Study
Silvia Limonta, Emmanuelle Cambau, Marie‐Line Erpelding, Caroline Piau-Couapel, François Goehringer, Matthieu Revest, Véronique Vernet-Garnier, Vincent Le Moing, Bruno Hoen, Xavier Duval, Pierre Tattevin, François Alla, A. Bouvet, Serge Briançon, M. Célard, Nicolas Danchin, Thanh Doco‐Lecompte, Jérôme Etienne, B Iung, J F Obadia, Christine Selton‐Suty, François Vandenesch, Yvette Bernard, Sidney Chocron, C Chirouze, Patrick Plésiat, I. Abouliatim, C. De Place, Pierre-Yves Donnio, C. Lion, Nejla Aissa, B Baehrel, R. Jaussaud, Pierre Nazeyrollas, V Vernet, Christian Chidiac, François Delahaye, Hugues Aumaître, Jérôme Frappier, E. Oziol, Albert Sotto, Catherine Sportouch, Michèle Bes, P. Abassade, Elie Abrial, C Acar, J.F. Alexandra, N. Amireche, D Amrein, P André, M Appriou, Marc‐Antoine Arnould, Patrick Assayag, Ali Atoui, F. Aziza, N Baille, N. Bajolle, Pascal Battistella, S. Baumard, A Ben Ali, Joris A. M. Bertrand, Sławomir Białek, M. Bois Grosse, M. Boixados, Felippe Borlot, Amir Bouchachi, Olivier Bouché, S. Bouchemal, Jérémie Bourdon, Lucien Brasme, François Bricaire, Éric Brochet, J. F. Bruntz, Anne Cady, Johann Cailhol, Morgan Caplan, B. Carette, O. Cartry, C. Cazorla, H. Chamagne, H. Champagne, Gérald Chanques, Jean Chastre, Bernard Chevalier, F. Chometon, Catherine Christophe, Ariel Cohen, Nathalie Verdière, V. Daneluzzi, Leonor David, P. De Lentdecker, V. Delcey, Philippe Deleuze, Erwan Donal, Benjamin Deroure, Vincent Descotes‐Genon, K. Didier Petit, Aurélien Dinh, Violaine Doat, François Duchêne, F. Duhoux, Madeleine Dupont, Stéphane Éderhy, Olivier Épaulard, M. Evest, Jean‐François Faucher, B. Fantin, E Fauveau, Tristan Ferry, M. Fillod, Thierry Floch, T. Fraisse, J. M. Frapier, L. Freysz, B. Fumery, Bertrand Gachot, Sébastien Gallien, I. Gandjbach, Philippe Garçon, Aimée Gaubert, J Genoud, Sabrina Ghiglione, Christian Godreuil, Alain Grentzinger, L. Groben, Djalel Eddine Gherissi, Pierre Guéret, Albert Hagège, Nadjib Hammoudi, F. Heliot, P. Henry, S. Herson, P. Houriez, L Hustache-Mathieu, Olivier Huttin, Sébastien Imbert, Stéphane Jauréguiberry, Mahmoud Kaaki, A. Konaté, J M Kuhn, S. Kural Menasche, A Lafitte, B Lafon, Fanny Lanternier, V. Le Chenault, Catherine Lechiche, S. Lefèvre‐Thibaut, A. Lefort, Alain Leguerrier, Jean-Marie Lemoine, Laurent Lepage, C. Lepousé, J. Leroy, P. Lesprit, L. Letranchant, D Loisance, Goran Loncar, C Lorentz, P. Mabo, Isabelle Magnin‐Poull, T. May, Alain Makinson, H Man, Majdi Mansouri, O Marcxon, J. P. Maroni, Vincent Massé, F. Maurier, M C Meyohas, Pierre-Louis Michel, C. Michelet, F. Méchaï, Olivier Merceron, David Messika–Zeitoun, Vanina Meyssonnier, Chaouki Mezher, Sara Micheli, Michel Monsigny, Stéphane Mouly, Bruno Mourvillier, O. Nallet, T. Papo, B. Payet, Andrea Pelletier, Pierre Perez, Jérôme Petit, François Philippart, Emilie Piet, Céline Plainvert, Batric Popovic, J Porte, P. Pradier, R. Ramadan, J Richemond, M. Rodermann, M Roncato, I. Roigt, O. Ruyer, Matthieu Saada, Jacqueline Schwartz, Matthew S. Simon, B. Simorre, S. Skalli, F Spatz, J. Sudrial, Lamia Tartière, A Terrier De La Chaise, M. C. Thiercelin, Daniel Thomas, Martín Thomas, L. Toko, François Tournoux, Anne Tristan, J. Trouillet, L. Tual, Alec Vahanian, F Verdier, Véronique Vernet Garnier, Verónica Vidal, P. Weyne, Michel Wolff, Alain Wynckel, N. Zannad, Pierre Yves Zinzius
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Résumé fourni par la source
Abstract Background Increased access to heart valves through early surgery and progress in molecular microbiology have reduced the proportion of infective endocarditis (IE) with no microbiological documentation and increased the proportion of IE associated with unusual microorganisms. Methods We performed an ancillary study of a large prospective population-based survey on IE. Unusual-microorganism IE was defined as definite IE (Duke-Li criteria) due to microorganisms other than streptococci, staphylococci, or enterococci. Results Of 471 cases of documented IE, 46 (9.8%) were due to unusal microorganisms; the following were involved in >1 case: Candida albicans (n = 4), Cutibacterium acnes (n = 4), Pseudomonas aeruginosa (n = 3), Cardiobacterium hominis (n = 3), and Coxiella burnetii (n = 2). Cases were documented with blood cultures (n = 37, 80.4%), heart valve polymerase chain reaction (PCR; n = 5), heart valve culture (n = 2), PCR on vertebral biopsy (n = 1), or serology (n = 1). As compared with IE due to staphylococci, streptococci, or enterococci (n = 420), IE due to unusual microorganisms occurred more frequently in patients with previously known heart disease (69.0% vs 44.3%; P = .002), prosthetic valve (40.5% vs 18.1%; P = .0006), longer duration of fever (mean, 35.1 ± 46.8 days vs 12.5 ± 17.8; P = .003), and who were more often nosocomial (38.1% vs 20.2%; P = .02). Conclusions In this population-based study, 9.8% of IE cases were due to unusual microorganisms, with a predominance of anaerobes, yeast, and gram-negative bacilli. As compared with IE related to staphylococci, streptococci, or enterococci, IE cases related to unusual microorganisms were associated with previously known heart disease, prosthetic valve, longer duration of fever, and nosocomial acquisition. Trial registration ORCID 0000-0003-3617-5411
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