Accès ouvert déclaré 2020 article

Mesial temporal resection following long‐term ambulatory intracranial EEG monitoring with a direct brain‐responsive neurostimulation system

Lawrence J. Hirsch, Emily A. Mirro, Vicenta Salanova, Thomas C. Witt, Cornelia Natasha Drees, Mesha‐Gay Brown, Ricky W. Lee, Toni L. Sadler, Elizabeth A. Felton, Paul A. Rutecki, Hae Won Shin, Eldad J. Hadar, Manu Hegde, Vikram R. Rao, Lilit Mnatsakanyan, Deepak Madhavan, Tarek Zakaria, Anli A. Liu, Christianne N. Heck, Janet E. Greenwood, Jeffrey K Bigelow, Dileep R Nair, Andreas V. Alexopoulos, Michael Mackow, Jonathan Edwards, Nadia Sotudeh, Ruben Kuzniecky, Ryder P. Gwinn, Michael John Doherty, Eric B. Geller, Martha J. Morrell

88Citations signalées, ce qui n’est pas une note de qualité

21Institutions déclarées

1Pays d’affiliation déclarés

Rattachement africain : us. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

OBJECTIVE: To describe seizure outcomes in patients with medically refractory epilepsy who had evidence of bilateral mesial temporal lobe (MTL) seizure onsets and underwent MTL resection based on chronic ambulatory intracranial EEG (ICEEG) data from a direct brain-responsive neurostimulator (RNS) system. METHODS: We retrospectively identified all patients at 17 epilepsy centers with MTL epilepsy who were treated with the RNS System using bilateral MTL leads, and in whom an MTL resection was subsequently performed. Presumed lateralization based on routine presurgical approaches was compared to lateralization determined by RNS System chronic ambulatory ICEEG recordings. The primary outcome was frequency of disabling seizures at last 3-month follow-up after MTL resection compared to seizure frequency 3 months before MTL resection. RESULTS: We identified 157 patients treated with the RNS System with bilateral MTL leads due to presumed bitemporal epilepsy. Twenty-five patients (16%) subsequently had an MTL resection informed by chronic ambulatory ICEEG (mean = 42 months ICEEG); follow-up was available for 24 patients. After MTL resection, the median reduction in disabling seizures at last follow-up was 100% (mean: 94%; range: 50%-100%). Nine patients (38%) had exclusively unilateral electrographic seizures recorded by chronic ambulatory ICEEG and all were seizure-free at last follow-up after MTL resection; eight of nine continued RNS System treatment. Fifteen patients (62%) had bilateral MTL electrographic seizures, had an MTL resection on the more active side, continued RNS System treatment, and achieved a median clinical seizure reduction of 100% (mean: 90%; range: 50%-100%) at last follow-up, with eight of fifteen seizure-free. For those with more than 1 year of follow-up (N = 21), 15 patients (71%) were seizure-free during the most recent year, including all eight patients with unilateral onsets and 7 of 13 patients (54%) with bilateral onsets. SIGNIFICANCE: Chronic ambulatory ICEEG data provide information about lateralization of MTL seizures and can identify additional patients who may benefit from MTL resection.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Mesial temporal resection following long‐term ambulatory intracranial EEG monitoring with a direct brain‐responsive neurostimulation system
Date Crossref: 18/02/2020
Éditeur: Wiley
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Yale University pays non établi dans la notice
Université ou école supérieure
NeuroPace (United States) pays non établi dans la notice
Entreprise
Indiana University School of Medicine pays non établi dans la notice
Université ou école supérieure
Indiana University – Purdue University Indianapolis pays non établi dans la notice
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University of Colorado Denver pays non établi dans la notice
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Ascension Via Christi pays non établi dans la notice
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UW Health University Hospital pays non établi dans la notice
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University of North Carolina at Chapel Hill pays non établi dans la notice
Université ou école supérieure
University of California Weill Institute for Neurosciences pays non établi dans la notice
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University of Nebraska Medical Center pays non établi dans la notice
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Memorial Healthcare System pays non établi dans la notice
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New York University pays non établi dans la notice
Université ou école supérieure

Yale University, NeuroPace (United States) et Indiana University School of Medicine, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Neurological disorders and treatmentsTranscranial Magnetic Stimulation StudiesVagus Nerve Stimulation Research

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