Accès ouvert déclaré 2020 article

The landscape of viral associations in human cancers

Marc Zapatka, Ivan Borozan, Daniel S. Brewer, Murat Iskar, Adam T. Grundhoff, Malik Alawi, Holger Sültmann, Holger Moch, Nikita Desai, Roland Eils, Vincent Ferretti, Kortine Kleinheinz, Peter Lichter, Hidewaki Nakagawa, Akinyemi I. Ojesina, Chandra Sekhar Pedamallu, Matthias Schlesner, Colin S. Cooper, Lauri A. Aaltonen, Federico Abascal, Adam Abeshouse, Hiroyuki Aburatani, David J. Adams, Nishant Agrawal, Keun Soo Ahn, Sung‐Min Ahn, Hiroshi Aikata, Rehan Akbani, Kadir Caner Akdemir, Hikmat A Al‐Ahmadie, Sultan T. Al‐Sedairy, Fátima Al‐Shahrour, Monique Albert, Kenneth Aldape, Ludmil B. Alexandrov, Adrian Ally, Kathryn Alsop, Eva G. Álvarez, Fernanda M Amary, Samirkumar B. Amin, Brice Aminou, Ole Ammerpohl, Matthew J. Anderson, Yeng Shiong Ang, Davide Antonello, Pavana Anur, Samuel A. J. R. Aparicio, Elizabeth L. Appelbaum, Yasuhito Arai, Axel Aretz, Koji Arihiro, Shun‐ichi Ariizumi, Joshua Armenia, Laurent Arnould, Sylvia L. Asa, Yassen Assenov, Gurnit Atwal, Sietse Aukema, J. Todd Auman, Miriam R. R. Aure, Philip Awadalla, Marta Aymerich, Gary D. Bader, Adrian Baez‐Ortega, Peter J. Bailey, Miruna Balasundaram, Saianand Balu, Pratiti Bandopadhayay, Rosamonde Elizabeth Banks, Stefano Barbi, Andrew P. Barbour, Jonathan Barenboim, Jill S. Barnholtz‐Sloan, Hugh Barr, Elisabet Barrera, John Bartlett, Javier Bartolomé, Claudio Bassi, Oliver F. Bathe, Daniel Baumhoer, Prashant P. Bavi, Stephen B. Baylin, Wojciech Bażant, Duncan Beardsmore, Tim Beck, Sam Behjati, Andreas Behren, Beifang Niu, Cindy Bell, Sergi Beltrán, Christopher C. Benz, Andrew Berchuck, Anke K. Bergmann, Erik N. Bergstrom, Benjamin Paul Berman, Daniel Maurice Berney, Rameen Beroukhim, Mario Berríos, Samantha Bersani, Johanna Bertl, Miguel Betancourt, Vinayak Bhandari, Shriram G. Bhosle, Andrew Victor Biankin, Matthias Bieg, Darell D. Bigner, Hans Binder, Ewan Birney, Michael J. Birrer, Nidhan K. 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Hepperla, José María Heredia‐Genestar, Carl Herrmann, Peter Hersey, Julian M. Hess, Hólmfríður Hilmarsdóttir, Jonathan Hinton, Satoshi Hirano, Nobuyoshi Hiraoka, Katherine A. Hoadley, Asger Hobolth, Ermin Hodzic, Jessica I. Hoell, Steve Hoffmann, Oliver Hofmann, Andrea Holbrook, Aliaksei Z. Holik, Michael Anthony Hollingsworth, Oliver Holmes, Robert A. Holt, Chen Hong, Eun Pyo Hong, Jongwhi H. Hong, Gerrit K. J. Hooijer, Henrik Hornshøj, Fumie Hosoda, Yong Hou, Volker Hovestadt, William Howat, Alan P. Hoyle, Ralph H. Hruban, Taobo Hu, Xing Hua, Kuan-lin Huang, Mei Huang, Mi Ni Huang, Vincent J. Huang, Yi Huang, Wolfgang K. Huber, Thomas Jay Hudson, Michael Hummel, Jillian A. Hung, David George Huntsman, Ted R. Hupp, Jason T. Huse, Matthew R. Huska, Barbara Hutter, Carolyn M. Hutter, Daniel Hübschmann, Christine A. Iacobuzio–Donahue, Charles David Imbusch, Marcin B. Imielinski, Seiya Imoto, William B. Isaacs, Keren Isaev, Shumpei Ishikawa, S. M. Ashiqul Islam, Michael Ittmann, Sinisa Ivkovic, José M. G. Izarzugaza, Jocelyne Jacquemier, Valerie Jakrot, Nigel Balfour Jamieson, Gun Ho Jang, Se Jin Jang, Joy C. Jayaseelan, Reyka G. Jayasinghe, Karine Jegalian, Jennifer L. Jennings, Seung-Hyup Jeon, Lara Jerman, Yuan Ji, Wei Jiao, Peter A. Johansson, Amber L. Johns, Jeremy Johns, Todd A. Johnson, Clemency Jolly, Yann Joly, Jon Gunnlaugur Jonasson, Corbin D. Jones, David Jones, Nic Jones, Steven J.M. Jones, Jos Jonkers, Young Seok Ju, Hartmut H. Juhl, Jongsun Jung, Malene Juul, Randi Istrup Juul, Natalie Jäger, Rolf Kabbe, André Kahles, Abdullah Kahraman, Vera B. Kaiser, Hojabr Kakavand, Sangeetha N. Kalimuthu, Christof V. Kalle, Koo Jeong Kang, Katalin Karászi, Beth Y. Karlan, Rosa Karlić, Dennis Karsch, Katayoon Kasaian, Karin S. Kassahn, Hitoshi Katai, Mamoru Kato, Hiroto Katoh, Yoshiiku Kawakami, Jonathan D.S. Kay, Stephen H. Kazakoff, Marat D. Kazanov, Maria Keays, Electron Kebebew, Richard F. Kefford, Manolis Kellis, James G. Kench, Catherine J. Kennedy, Jules N. A. Kerssemakers, David Khoo, Vincent S Khoo, Narong Khuntikeo, Ekta Khurana, Helena Kilpinen, Hark Kyun Kim, Hyung‐Lae Kim, Hyung-Yong Kim, Hyunghwan Kim, Ji-Hoon Kim, Jong-Kwang Kim, Young-Wook Kim, Tari A. King, Leszek J. Klimczak, Stian Knappskog, Michael Kneba, Bartha Maria Knoppers, Youngil Koh, Daisuke Komura, Mitsuhiro Komura, Gu Kong, Marcel Kool, Jan O. Korbel, Viktoriya Korchina, Andrey Korshunov, Michael Koscher, Roelof Koster, Zsofia Kote‐Jarai, Antonios Koures, Milena Kovacevic, Bárbara Kremeyer, Helene Kretzmer, Markus Kreuz, Savitri Krishnamurthy, Dieter Kube, Kiran Kumar, Pardeep Kumar, Sushant Kumar, Yogesh Kumar, Ritika Kundra, Kirsten Kübler, Ralf Küppers, Jesper Lagergren, Phillip H. Lai, Peter W. Laird, Sunil R. Lakhani, Christopher M. Lalansingh, Emilie Lalonde, Fabien Claude Lamaze, Adam G. Lambert, Eric Michael Lander, Pablo Landgraf, Luca Landoni, Anita Langerød, Andrés Lanzós, Denis Larsimont, Erik G. Larsson, Mark Lathrop, Loretta M. S. Lau, Chris Lawerenz, Rita Teresa Lawlor, Michael S. Lawrence, Alexander J. Lazar, Ana Mijalkovic Lazic, Xuan Le, Darlene Lee, Dong-Hoon Lee, Eunjung Alice Lee, Hee Jin Lee, Jake June-Koo Lee, Jeong‐Yeon Lee, Ju‐Hee Lee, Ming Ta Michael Lee, Henry Lee-Six, Kjong-Van Lehmann, Hans Lehrach, Dido Lenze, Conrad Leonard, Daniel A. Leongamornlert, Ignaty Leshchiner, Louis Létourneau, Ivica Letunić, Douglas A. Levine, Lora R Lewis, Tim Ley, Chang Li, Constance H. Li, Haiyan Irene Li, Jun Li, Lin Li, Shantao Li, Siliang Li, Xiaobo Li, Xiaotong Li, Xinyue Li, Yilong Li, Han Liang, Sheng‐Ben Liang, Pei Yi Lin, Ziao Lin, W. M. Linehan, Ole Christian Lingjærde, Dongbing Liu, Eric Minwei Liu, Fei-Fei Fei Liu, Fenglin Liu, Jia Liu, Xingmin Liu, Julie M. Livingstone, Dimitri G. Livitz, Naomi Livni, Lucas Lochovsky, Markus Loeffler, Georgina Venetia Long, Armando López‐Guillermo, Shaoke Lou, David N. Louis, Laurence B. 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McLellan, John D. McPherson, John R. McPherson, Treasa A. McPherson, Samuel R. Meier, Alice X. Meng, Shaowu Meng, Andrew H. Menzies, Neil Donald Merrett, Sue Merson, Matthew Meyerson, Piotr A. Mieczkowski, George L. Mihaiescu, Sanja Mijalković, Tom Mikkelsen, Michèle Milella, Linda Mileshkin, Christopher A. Miller, David K. Miller, Jessica K. Miller, Gordon Brent Mills, Ana Milovanovic, Sarah Jane Pauline Minner, Marco Miotto, Gisela Mir Arnau, Lisa Mirabello, Thomas J. Mitchell, Satoru Miyano, Naoki Miyoshi, Shinichi Mizuno, Fruzsina Molnár-Gábor, Malcolm J. Moore, Richard A. Moore, Sandro Morganella, Quaid Morris, Lisle E. Mose, Catherine D. Moser, Ferran Muiños, Loris Mularoni, Andrew J. J. Mungall, Karen Mungall, Elizabeth A. Musgrove, Ville Mustonen, David G. Mutch, Francesc Muyas, Donna Marie Muzny, Alfonso Muñoz, Jerome Myers, Ola Myklebost, Peter Möller, Genta Nagae, Adnan M. Nagrial, Hardeep K. Nahal-Bose, Hitoshi Nakagama, Hiromi K. 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Francis Ouellette, Christine P’ng, Marta Paczkowska, Salvatore Paiella, Chawalit Pairojkul, Marina Pajic, Qiang Pan‐Hammarström, Elli Papaemmanuil, Irene Papatheodorou, Nagarajan Paramasivam, Ji Wan Park, Joong-Won Park, Keunchil Park, Kiejung Park, Peter J. Park, Joel S. Parker, Simon L. Parsons, Harvey Ira Pass, Danielle Pasternack, Alessandro Pastore, Ann‐Marie Patch, Iris Pauporté, Antonio Pea, John V. Pearson, Jakob Skou Pedersen, Paolo Pederzoli, Martin Peifer, Nathan A. Pennell, Charles M. Perou, Marc D. Perry, Gloria M. Petersen, Myron Peto, Nicholas James Petrelli, Robert Petryszak, Stefan M. Pfister, Mark Phillips, Oriol Pich, Hilda A. Pickett, Todd Pihl, Nischalan Pillay, Sarah E. Pinder, Mark Pinese, Andreia V. Pinho, Esa Pitkänen, Xavier Pivot, Elena Piñeiro-Yáñez, Laura Planko, Christoph Plass, Paz P Polak, Tirso Pons, Irinel Popescu, Olga Potapova, Aparna Prasad, Shaun R. Preston, Manuel Prinz, Antonia L. Pritchard, Stephenie D. Prokopec, Elena Provenzano, Xosé S. 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Seethala, Ayellet V. Segrè, Iris Selander, Colin A M Semple, Yasin Şenbabaoğlu, Subhajit Sengupta, Elisabetta Sereni, Stefano Serra, Dennis C. Sgroi, Mark J. Shackleton, Nimish C Shah, Sagedeh Shahabi, Catherine A. Shang, Ping Shang, Ofer Shapira, Troy Shelton, Ciyue Shen, Hui Shen, Rebecca F. Shepherd, Ruian Shi, Yan Shi, Yu-Jia Shiah, Tatsuhiro Shibata, Juliann Shih, Eigo Shimizu, Kiyo Shimizu, Seung Jun Shin, Yuichi Shiraishi, Tal Shmaya, Ilya Shmulevich, Solomon I. Shorser, Charles L. Short, Raunak Shrestha, Suyash Shringarpure, Craig D. Shriver, Shimin Shuai, Nikos Sidiropoulos, Reiner Siebert, Anieta M. Sieuwerts, Lina Sieverling, Sabina Signoretti, Katarzyna O. Sikora, Michele Simbolo, Ronald Simon, Janae V. Simons, Jared T. Simpson, Peter T. Simpson, Samuel Singer, Nasa Sinnott-Armstrong, Payal Sipahimalani, Tara J. Skelly, Marcel Smid, John A. Smith, Karen Smith‐McCune, Nicholas D. Socci, Heidi J. Sofia, Matthew G. Soloway, Lei Song, Anil K. Sood, Sharmila Sothi, Christos P. 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Yung, Olga Zaikova, Jorge Zamora, Jean Claude Zenklusen, Thorsten Zenz, Nikolajs Zeps, Cheng‐Zhong Zhang, Fan Zhang, Hailei Zhang, Hongwei Zhang, Hongxin Zhang, Jiashan Zhang, Jing Zhang, Junjun Zhang, Xiuqing Zhang, Xuanping Zhang, Yan Zhang, Zemin Zhang, Zhongming Zhao, Liangtao Zheng, Xiuqing Zheng, Wanding Zhou, Yong Zhou, Bin Zhu, Hongtu Zhu, Jingchun Zhu, Shida Zhu, Lihua Zou, Xueqing Zou, Anna DeFazio, Nicholas J. van As, Carolien H. M. van Deurzen, Marc J. van de Vijver, L. van’t Veer, Christian von Mering

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481Institutions déclarées

36Pays d’affiliation déclarés

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Le résumé fourni par la source

Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and-for a subset-whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome datasets. We found a high prevalence of known tumor-associated viruses such as Epstein-Barr virus (EBV), hepatitis B virus (HBV) and human papilloma virus (HPV; for example, HPV16 or HPV18). The study revealed significant exclusivity of HPV and driver mutations in head-and-neck cancer and the association of HPV with APOBEC mutational signatures, which suggests that impaired antiviral defense is a driving force in cervical, bladder and head-and-neck carcinoma. For HBV, HPV16, HPV18 and adeno-associated virus-2 (AAV2), viral integration was associated with local variations in genomic copy numbers. Integrations at the TERT promoter were associated with high telomerase expression evidently activating this tumor-driving process. High levels of endogenous retrovirus (ERV1) expression were linked to a worse survival outcome in patients with kidney cancer.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: The landscape of viral associations in human cancers
Date Crossref: 05/02/2020
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

German Cancer Research Center Division of Molecular Genetics pays non établi dans la notice
Structure de recherche
Heidelberg University Department of Bioinformatics and Functional Genomics pays non établi dans la notice
Université ou école supérieure
Ontario Institute for Cancer Research Informatics and Bio-computing Program pays non établi dans la notice
Organisme public
University of East Anglia Norwich Medical School pays non établi dans la notice
Université ou école supérieure
Earlham Institute pays non établi dans la notice
Structure de recherche
Leibniz Institute of Virology (LIV) pays non établi dans la notice
Structure de recherche
German Center for Infection Research pays non établi dans la notice
Structure de recherche
Universität Hamburg pays non établi dans la notice
Université ou école supérieure
University Medical Center Hamburg-Eppendorf Bioinformatics Core pays non établi dans la notice
Établissement de santé
The Francis Crick Institute pays non établi dans la notice
Structure de recherche
University College London Department of Computer Science pays non établi dans la notice
Université ou école supérieure
National Center for Tumor Diseases pays non établi dans la notice
Organisme public

Division of Molecular Genetics — German Cancer Research Center, Department of Bioinformatics and Functional Genomics — Heidelberg University et Informatics and Bio-computing Program — Ontario Institute for Cancer Research, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Viral-associated cancers and disordersPolyomavirus and related diseasesAnimal Virus Infections Studies

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