Accès ouvert déclaré 2020 article

Integrative pathway enrichment analysis of multivariate omics data

Marta Paczkowska, Jonathan Barenboim, Nardnisa Sintupisut, Natalie S. Fox, Helen Zhu, Diala Abd-Rabbo, Miles W. Mee, Paul Christopher Boutros, Federico Abascal, Samirkumar B. Amin, Rameen Beroukhim, Johanna Bertl, Søren Brunak, Peter J. Campbell, Joana Carlevaro-Fita, Dimple Chakravarty, Ken Chen, Jordi Deu-Pons, Priyanka Dhingra, Klev Diamanti, Lars Feuerbach, J. Lynn Fink, Nuno A. Fonseca, Joan Frigola, Carlo B Gambacorti-Passerini, Dale W. Garsed, Mark Gerstein, Gad A. Getz, Abel González-Pérez, Qianyun Guo, Ivo Glynne Gut, David Haan, Mark P. Hamilton, Nicholas J. Haradhvala, Arif O. Harmanci, Mohamed Ahmed Helmy, Carl Herrmann, Julian M. Hess, Ermin Hodzic, Chen Hong, Henrik Hornshøj, Keren Isaev, José M. G. Izarzugaza, Rory Johnson, Todd A. Johnson, Randi Istrup Juul, Ekta Khurana, Jaegil Kim, Jong K. Kim, Young-Wook Kim, Jan O. Korbel, Sushant Kumar, Andrés Lanzós, Kjong-Van Lehmann, Xiaotong Li, Ziao Lin, Eric Minwei Liu, Shaoke Lou, Kathleen Marchal, Alexander Martinez‐Fundichely, Yosef E. Maruvka, Patrick D. McGillivray, William Meyerson, Ferran Muiños, Hidewaki Nakagawa, Morten Muhlig Nielsen, Keunchil Park, Kiejung Park, Jakob Skou Pedersen, Oriol Pich, Tirso Pons, Sergio Pulido-Tamayo, Iker Reyes-Salazar, Matthew A. Reyna, Esther Rheinbay, Mark Andrew Rubin, Carlota Rubio-Pérez, Radhakrishnan Sabarinathan, S. Cenk Şahinalp, Gordon Saksena, Leonidas Salichos, Steven E. Schumacher, Ofer Shapira, Ciyue Shen, Raunak Shrestha, Shimin Shuai, Lina Sieverling, Lincoln Stein, Joshua M. Stuart, David Tamborero, Tatsuhiko Tsunoda, Husen Muhammad Umer, Liis Uusküla-Reimand, Alfonso Valencia, Lieven P. C. Verbeke, Jonathan Warrell, Sebastian M. Waszak, Guanming Wu, Jun Yu, Jing Zhang, Xuanping Zhang, Yan Zhang, Zhongming Zhao, Christian von Mering, Jüri Reimand, Lauri A. Aaltonen, Adam Abeshouse, Hiroyuki Aburatani, David J. Adams, Nishant Agrawal, Keun Soo Ahn, Sung‐Min Ahn, Hiroshi Aikata, Rehan Akbani, Kadir Caner Akdemir, Hikmat A Al‐Ahmadie, Sultan T. Al‐Sedairy, Fátima Al‐Shahrour, Malik Alawi, Monique Albert, Kenneth Aldape, Ludmil B. Alexandrov, Adrian Ally, Kathryn Alsop, Eva G. Álvarez, Fernanda M Amary, Brice Aminou, Ole Ammerpohl, Matthew J. J. Anderson, Yeng Shiong Ang, Davide Antonello, Pavana Anur, Samuel A. J. R. Aparicio, Elizabeth L. Appelbaum, Yasuhito Arai, Axel Aretz, Koji Arihiro, Shun‐ichi Ariizumi, Joshua Armenia, Laurent Arnould, Sylvia L. Asa, Yassen Assenov, Gurnit Atwal, Sietse Aukema, J. Todd Auman, Miriam R. R. Aure, Philip Awadalla, Marta Aymerich, Adrian Baez‐Ortega, Matthew H. Bailey, Peter J. Bailey, Miruna Balasundaram, Saianand Balu, Pratiti Bandopadhayay, Rosamonde Elizabeth Banks, Stefano Barbi, Andrew P. Barbour, Jill S. Barnholtz‐Sloan, Hugh Barr, Elisabet Barrera, John A Bartlett, Javier Bartolomé, Claudio Bassi, Oliver F. Bathe, Daniel Baumhoer, Prashant P. Bavi, Stephen B. Baylin, Wojciech Bażant, Duncan Beardsmore, Tim Beck, Sam Behjati, Andreas Behren, Beifang Niu, Cindy Bell, Sergi Beltrán, Christopher C. Benz, Andrew Berchuck, Anke Katharina Bergmann, Erik N. Bergstrom, Benjamin Paul Berman, Daniel Maurice Berney, Mario Berríos, Samantha Bersani, Miguel Betancourt, Vinayak Bhandari, Shriram G. Bhosle, Andrew Victor Biankin, Matthias Bieg, Darell D. Bigner, Hans Binder, Ewan Birney, Michael Birrer, Nidhan K. Biswas, Bodil Bjerkehagen, Tom Bodenheimer, Lori Boice, Giada Bonizzato, Johann Sebastian De Bono, Arnoud Boot, Åke Borg, Arndt Borkhardt, Ivan Borozan, Christoph W. Borst, Marcus Bosenberg, Mattia Bosio, Jacqueline Boultwood, Guillaume Bourque, G. Steven Bova, David Bowen, Reanne Bowlby, David D.L. Bowtell, Sandrine Boyault, Rich Boyce, Jeffrey M. Boyd, Alvis Brāzma, Paul Brennan, Daniel S. Brewer, Arie B. Brinkman, Robert Glen Bristow, Russell R. Broaddus, Jane E. Brock, Malcolm V. Brock, Annegien Broeks, Angela Norie Brooks, Denise Brooks, Benedikt Brors, Timothy J. C. Bruxner, Alicia L. Bruzos, Alex Buchanan, Ivo Buchhalter, Christiane Buchholz, Susan Bullman, Hazel Burke, Birgit Burkhardt, Kathleen H. Burns, John P. Busanovich, Carlos D. Bustamante, Adam P. Butler, Atul Janardhan Butte, Niall J. Byrne, Anne‐Lise Børresen‐Dale, Andy Cafferkey, Declan J. Cahill, Claudia Calabrese, Carlos H. Caldas, Fabien M. Calvo, Niedzica Camacho, Elı́as Campo, Cinzia Cantù, Shaolong Cao, Thomas E. Carey, Rebecca Birch Carlsen, Ivana Cataldo, Mario Cazzola, Jonathan Simon Cebon, Robert Cerfolio, Dianne E. Chadwick, Drc Chalmers, Kin Chan, Michelle Chan Seng Yue, Vishal Suresh Chandan, David Kuang-Fu Chang, Stephen Jacob Chanock, Aurélien Chateigner, Nilanjan Chatterjee, Kazuaki Chayama, Hsiao-Wei Chen, Jieming Chen, Yiwen Chen, Zhaohong Chen, Andrew D. Cherniack, JEREMY R. CHIEN, Yoke-Eng Chiew, Suet‐Feung Chin, Juok Cho, Sunghoon Cho, Wan Choi, Christine Chomienne, Zechen Chong, Su Pin Choo, Angela S. Y. Chou, Angelika N. Christ, Elizabeth L. Christie, Eric Chuah, Carrie Cibulskis, Kristian Cibulskis, Sara Cingarlini, Peter Clapham, Alexander Claviez, Sean Patrick Cleary, Nicole Cloonan, Marek Cmero, Colin C. Collins, Ashton Anthony Connor, Susanna L. Cooke, Colin S. Cooper, Leslie Cope, Vincenzo Corbo, Matthew G. Cordes, Stephen M. Cordner, Isidro Cortés‐Ciriano, Kyle R. Covington, Prue A. Cowin, Brian Craft, David Craft, Chad J. Creighton, Yupeng Cun, Erin E. Curley, Ioana Cutcutache, Karolina M. Czajka, Bogdan A. Czerniak, Rebecca A. Dagg, Ludmila Danilova, Maria Vittoria Davì, Natalie R. Davidson, Helen Ruth Davies, Ian J. Davis, Brandi N. Davis‐Dusenbery, Kevin J. Dawson, Francisco M. De La Vega, Ricardo De Paoli‐Iseppi, Timothy Defreitas, Angelo Paolo Dei Tos, Olivier Delaneau, John A. Demchok, Jonas Demeulemeester, German M. Demidov, Deniz Demircioğlu, Nening M. Dennis, Robert Edward Denroche, Stefan C. Dentro, Nikita Desai, Vikram Deshpande, Amit G. Deshwar, Christine Desmedt, Noreen Dhalla, Neesha C. Dhani, Rajiv Dhir, Anthony DiBiase, Li Ding, Huy Q. Dinh, Luc Yves Dirix, HarshaVardhan Doddapaneni, Nilgun Donmez, Michelle T. Dow, Ronny Drapkin, Oliver Drechsel, Ruben M. Drews, Serge Serge, Tim J. Dudderidge, Ana Dueso-Barroso, Andrew J Dunford, Michael G. Dunn, Lewis Jonathan Dursi, Fraser R. Duthie, Ken Dutton‐Regester, Jenna Eagles, Douglas F. Easton, Stuart D. Edmonds, Paul Alan Edwards, Sandra E. Edwards, Rosalind A. Eeles, Anna Ehinger, Roland Eils, Adel K. El‐Naggar, Matthew Eldridge, Kyle Ellrott, Serap Erkek, Geòrgia Escaramís, Shadrielle M. G. Espiritu, Xavier Estivill, Dariush Etemadmoghadam, Jorunn Erla Eyfjord, Bishoy M. Faltas, Daiming Fan, Yu Fan, William C. Faquin, Claudiu Farcas, Matteo Fassan, Aquila Fatima, Francesco Favero, Nodirjon Fayzullaev, Ina Felau, Sián Fereday, Martin L. Ferguson, Vincent Ferretti, Matthew A. Field, Gaetano Finocchiaro, Cyril Fisher, Matthew W. Fittall, Anna M. Fitzgerald, Rebecca C. Fitzgerald, Adrienne Margaret Flanagan, Neil Eric Fleshner, Paul Flicek, John A. Foekens, Kwun Meng Fong, Christopher S. Foster, Michael E. Fraser, Scott Frazer, Milana Frenkel‐Morgenstern, William A. Friedman, Catrina C. Fronick, Akihiro Fujimoto, Masashi Fujita, Masashi Fukayama, Lucinda A. Fulton, Robert S. Fulton, Mayuko Furuta, P. Andrew Futreal, Anja Füllgrabe, Stacey L. Gabriel, Steven N. Gallinger, Jianjiong Gao, Shengjie Gao, Levi A. Garraway, Øystein Garred, Erik P. Garrison, Nils Gehlenborg, Josep L. L. Gelpi, Joshy George, Daniela Se Gerhard, Clarissa Gerhäuser, Moritz Gerstung, Mohammed Ghori, Ronald A. Ghossein, Nasra H. Giama, Richard A. Gibbs, Bob Gibson, Anthony James Gill, Pelvender Gill, Dilip D. Giri, Dominik Głodzik, Vincent J. Gnanapragasam, Maria Elisabeth Goebler, Mary J. Goldman, Carmen Valladares Gomez, Santiago Gonzalez, Dmitry A. Gordenin, James Gossage, Kunihito Gotoh, Ramaswamy Govindan, Dorthe Aamand Grabau, Janet Shirley Graham, Robert C. Grant, Anthony Richard Green, Eric P Green, Liliana Greger, Nicola Grehan, Sonia Grimaldi, Sean Michael Grimmond, Robert L. Grossman, Adam T. Grundhoff, Gunes Gundem, Manaswi Gupta, Shailja Gupta, Jonathan Göke, Gavin Ha, Andrea Haake, Siegfried Haas, Kerstin Haase, James E. Haber, Faraz Hach, Syed W. Haider, Natsuko Hama, Freddie Charles Hamdy, Anne L. Hamilton, Leng Han, George B. Hanna, Martin Hansmann, Olivier Harismendy, Ivon Harliwong, Arif O. Harmanci, Eoghan Harrington, Takanori Hasegawa, David H. Haussler, Steve Hawkins, Shinya Hayami, Shuto Hayashi, David Neil Hayes, Stephen J. Hayes, Nicholas K. Hayward, Steven Hazell, Xiaotong Yao, Allison P. Heath, Simon Charles Heath, David William Hedley, Apurva M. Hegde, David I. Heiman, Michael C. Heinold, Zachary J. Heins, Lawrence E. Heisler, Eva Hellstrom-Lindberg, Seong Gu Heo, Austin J. Hepperla, José María Heredia‐Genestar, Peter Hersey, Hólmfríður Hilmarsdóttir, Jonathan Hinton, Satoshi Hirano, Nobuyoshi Hiraoka, Katherine A. Hoadley, Jessica I. Hoell, Steve Hoffmann, Oliver Hofmann, Andrea Holbrook, Aliaksei Z. Holik, Michael Anthony Hollingsworth, Oliver Holmes, Robert A. Holt, Chen Hong, Eun Pyo Hong, Jongwhi H. Hong, Gerrit K. J. Hooijer, Fumie Hosoda, Yong Hou, Volker Hovestadt, William Howat, Alan P. Hoyle, Ralph H. Hruban, Taobo Hu, Xing Hua, Kuan-lin Huang, Mei Juan Huang, Mi Ni Huang, Vincent Huang, Yi Huang, Wolfgang K. Huber, Thomas Jay Hudson, Michael Hummel, Jillian A. Hung, David George Huntsman, Ted R. Hupp, Jason T. Huse, Matthew R. Huska, Barbara Hutter, Carolyn M. Hutter, Daniel Hübschmann, Christine A. Iacobuzio–Donahue, Charles David Imbusch, Marcin B. Imielinski, Seiya Imoto, William B. Isaacs, Shumpei Ishikawa, Murat Iskar, S. M. Ashiqul Islam, Michael Ittmann, Sinisa Ivkovic, Jocelyne D. Jacquemier, Valerie Jakrot, Nigel Balfour Jamieson, Gun Ho Jang, Se Jin Jang, Joy C. Jayaseelan, Reyka G. Jayasinghe, Karine Jegalian, Jennifer L. Jennings, Seung-Hyup Jeon, Lara Jerman, Yuan Ji, Wei Jiao, Peter A. Johansson, Amber L. Johns, Jeremy Johns, Clemency Jolly, Yann Joly, Jon Gunnlaugur Jonasson, Corbin D. Jones, David Jones, Nic Jones, Steven J.M. Jones, Jos Jonkers, Young Seok Ju, Hartmut H. Juhl, Jongsun Jung, Natalie Jäger, Rolf Kabbe, Vera B. Kaiser, Hojabr Kakavand, Sangeetha N. Kalimuthu, Christof V. Kalle, Koo Jeong Kang, Katalin Karászi, Beth Y. Karlan, Rosa Karlić, Dennis Karsch, Katayoon Kasaian, Karin S. Kassahn, Hitoshi Katai, Mamoru Kato, Hiroto Katoh, Yoshiiku Kawakami, Jonathan D.S. Kay, Stephen H. Kazakoff, Marat D. Kazanov, Maria Keays, Electron Kebebew, Richard F. Kefford, James G. Kench, Catherine J. Kennedy, Jules N. A. Kerssemakers, David Khoo, Vincent S Khoo, Narong Khuntikeo, Helena Kilpinen, Hark Kyun Kim, Hyung‐Lae Kim, Hyung-Yong Kim, Hyunghwan Kim, Tari A. King, Kortine Kleinheinz, Leszek J. Klimczak, Stian Knappskog, Michael Kneba, Bartha Maria Knoppers, Youngil Koh, Daisuke Komura, Mitsuhiro Komura, Gu Kong, Marcel Kool, Viktoriya Korchina, Andrey Korshunov, Michael Koscher, Roelof Koster, Zsofia Kote‐Jarai, Antonios Koures, Milena Kovačević, Bárbara Kremeyer, Helene Kretzmer, Markus Kreuz, Savitri Krishnamurthy, Dieter Kube, Kiran Kumar, Pardeep Kumar, Yogesh Kumar, Ritika Kundra, Kirsten Kübler, Ralf Küppers, Jesper Lagergren, Phillip H. Lai, Peter W. Laird, Sunil R. Lakhani, Christopher M. Lalansingh, Emilie Lalonde, Fabien Claude Lamaze, Adam M. Lambert, Eric Lander, Pablo Landgraf, Luca Landoni, Anita Langerød, Denis Larsimont, Erik G. Larsson, Mark Lathrop, Loretta M. S. Lau, Chris Lawerenz, Rita Teresa Lawlor, Alexander J. Lazar, Ana Mijalkovic Lazic, Xuan Le, Darlene Lee, Eunjung Alice Lee, Hee Jin Lee, Jake June-Koo Lee, Jeong‐Yeon Lee, Ju‐Hee Lee, Ming Ta Michael Lee, Henry Lee-Six, Hans R. Lehrach, Dido Lenze, Conrad Leonard, Daniel A. Leongamornlert, Ignaty Leshchiner, Louis Létourneau, Ivica Letunić, Douglas A. Levine, Lora R Lewis, Tim Ley, Chang Li, Constance H. Li, Haiyan Irene Li, Jun Li, Lin Li, Siliang Li, Xiaobo Li, Xinyue Li, Yilong Li, Han Liang, Sheng‐Ben Liang, Peter Lichter, Pei Lin, William Marston Linehan, Ole Christian Lingjærde, Dongbing Liu, Fei-Fei Fei Liu, Fenglin Liu, Jia Liu, Xingmin Liu, Julie M. Livingstone, Dimitri G. Livitz, Naomi Livni, Markus W. Loeffler, Georgina Venetia Long, Armando López‐Guillermo, David N. Louis, Laurence B. Lovat, Yiling Lu, Yong‐Jie Lu, Youyong Lu, Claudio Luchini, Ilinca M. Lungu, Xuemei Luo, Hayley J. Luxton, Andy G. Lynch, Lisa Lype, Cristina Esquinas López, Carlos López-Otı́n, Eric Z. Ma, Yussanne Ma, Gaëtan Marie MacGrogan, Shona MacRae, Geoff Macintyre, Kazuhiro Maejima, Andrea Mafficini, Dennis T. Maglinte, Arindam Maitra, Partha P. Majumder, Luca Malcovati, Salem Malikić, Giuseppe Malleo, Graham J. Mann, Luisa Mantovani‐Löffler, Giovanni Marchegiani, Elaine R. Mardis, Adam A. Margolin, Maximillian G. Marin, Florian Markowetz, Julia Markowski, Jeffrey S. Marks, Tomàs Marquès‐Bonet, Marco A. Marra, Luke Marsden, John W.M. Martens, Sancha Martin, José Ignacio Martín-Subero, R. Jay Mashl, Charlie E. Massie, Thomas J. Matthew, Lucy Matthews, Erik Mayer, Simon Mayes, Michael A. Mayo, Faridah Mbabaali, Karen Smith McCune, Ultan McDermott, Michael D. McLellan, John D. McPherson, John Richard McPherson, Treasa A. McPherson, Samuel R. Meier, Alice Meng, Shaowu Meng, Andrew H. Menzies, Neil Donald Merrett, Sue Merson, Matthew Meyerson, Piotr A. Mieczkowski, George L. Mihaiescu, Sanja Mijalković, Tom Mikkelsen, Michele Stanislaw Milella, Linda Mileshkin, Christopher A. Miller, David K. Miller, Jessica K. Miller, Gordon Brent Mills, Ana Milovanovic, Sarah Jane Pauline Minner, Marco Miotto, Gisela Mir Arnau, Thomas J. Mitchell, Satoru Miyano, Naoki Miyoshi, Shinichi Mizuno, Fruzsina Molnár-Gábor, Malcolm J. Moore, Richard A. Moore, Sandro Morganella, Quaid Morris, Lisle E. Mose, Catherine D. Moser, Andrew J. J. Mungall, Karen Mungall, Elizabeth A. Musgrove, Ville Mustonen, David G. Mutch, Francesc Muyas, Donna Marie Muzny, Alfonso Muñoz, Jerome K. Myers, Ola Myklebost, Peter Möller, Genta Nagae, Adnan M. Nagrial, Hardeep K. Nahal-Bose, Hitoshi Nakagama, Hiromi K. Nakamura, Tõru Nakamura, Kaoru Nakano, Tannistha Nandi, Jyoti Nangalia, Mia Nastic, Arcadi Navarro, Fábio C. P. Navarro, David E. Neal, Gerd Nettekoven, Felicity Newell, Steven J. Newhouse, Yulia Newton, Alvin Wei Tian Ng, Chi‐Fai Ng, Jonathan Nicholson, David L. Nicol, Yongzhan Nie, G. Petur Nielsen, Serena Nik‐Zainal, Michael S. Noble, Kátia Nones, Paul A. Northcott, Faiyaz Notta, Brian D. O’Connor, Peter J. O’Donnell, Maria O’Donovan, Sarah O’Meara, Brian Patrick O’Neill, J. Robert O’Neill, David Ocaña, Angelica Ochoa, Layla Oesper, Christopher W. Ogden, Hideki Ohdan, Kazuhiro Ohi, Lucila Ohno‐Machado, Karin A. Oien, Akinyemi I. Ojesina, Hidenori Ojima, Takuji Okusaka, Larsson Omberg, Choon Kiat Ong, Stephan Ossowski, German Ott, B. F. Francis Ouellette, Christine P’ng, Salvatore Paiella, Chawalit Pairojkul, Marina Pajic, Qiang Pan‐Hammarström, Elli Papaemmanuil, Irene Papatheodorou, Nagarajan Paramasivam, Ji Wan Park, Joong‐Won Park, Peter J. Park, Joel S. Parker, Simon L. Parsons, Harvey Ira Pass, Danielle Pasternack, Alessandro Pastore, Ann‐Marie Patch, Iris Pauporté, Antonio Pea, John V. Pearson, Chandra Sekhar Pedamallu, Paolo Pederzoli, Martin Peifer, Nathan A. Pennell, Charles M. Perou, Marc D. Perry, Gloria M. Petersen, Myron Peto, Nicholas Petrelli, Robert Petryszak, Stefan M. Pfister, Mark Phillips, Hilda A. Pickett, Todd Pihl, Nischalan Pillay, Sarah Pinder, Mark Pinese, Andreia V. Pinho, Esa Pitkänen, Xavier Pivot, Elena Piñeiro-Yáñez, Laura Planko, Christoph Plass, Paz P Polak, Irinel Popescu, Olga Potapova, Aparna Prasad, Shaun R. Preston, Manuel Prinz, Antonia L. Pritchard, Stephenie D. Prokopec, Elena Provenzano, Xosé S. Puente, Montserrat Puiggròs, Gulietta M. Pupo, Colin A. Purdie, Michael C. J. Quinn, Raquel Rabionet, Janet Sue Rader, Bernhard Radlwimmer, Petar Radovic, Benjamin Raeder, Keiran M. Raine, Manasa Ramakrishna, Kamna Ramakrishnan, Suresh Ramalingam, W. Kimryn Rathmell, Tobias Rausch, Guido Reifenberger, Jorge Sergio Reis-Filho, Victor E. Reuter, Sheila M. Reynolds, Yasser Riazalhosseini, Andrea L. Richardson, Julia Richter, Matthew David Ringel, Markus Ringnér, Yasushi Rino, Karsten Rippe, Jeffrey M. Roach, Lewis Rowland Roberts, Nicola D. Roberts, Steven A. Roberts, A. Gordon Robertson, Alan J. Robertson, Javier Bartolomé Rodriguez, Bernardo Rodríguez–Martín, Francisco Germán Rodríguez-González, Michael H. A. Roehrl, Marius Rohde, Hirofumi Rokutan, Gilles Romieu, Ilse Rooman, Tom W. Roques, Daniel Rosebrock, Mara W. Rosenberg, Philip C Rosenstiel, Andreas Rosenwald, Edward Rowe, Romina Royo, Steve Rozen, Yulia Rubanova, Vasilisa A. Rudneva, Borislav Chavdarov Rusev, Andrea Ruzzenente, Gunnar Rätsch, Veronica Y. Sabelnykova, Sara Sadeghi, Natalie Saini, Mihoko Saito-Adachi, Adriana Salcedo, Roberto Salgado, Richard C. Sallari, Charles F. Saller, Roberto Salvia, Michelle Sam, Jaswinder Singh Samra, Francisco Sánchez-Vega, Grant Sanders, Rajiv Sarin, Iman Sarrafi, Aya Sasaki-Oku, Torill Sauer, Guido Sauter, Robyn P.M. Saw, Maria Scardoni, Christopher James Scarlett, Aldo Scarpa, Ghislaine Scélo, Dirk Schadendorf, Jacqueline E. Schein, Markus B. Schilhabel, Matthias Schlesner, Thorsten Schlomm, Heather K. Schmidt, Sarah‐Jane Schramm, Stefan Schreiber, Nikolaus D. Schultz, Roland F. Schwarz, Richard A. Scolyer, David A. Scott, Ralph Scully, Raja S. Seethala, Ayellet V. Segrè, Iris Selander, Colin A M Semple, Yasin Şenbabaoğlu, Subhajit Sengupta, Elisabetta Sereni, Stefano Serra, Dennis C. Sgroi, Nimish C Shah, Sagedeh Shahabi, Catherine A. Shang, Ping Shang, Troy Shelton, Hui Shen, Rebecca F. Shepherd, Ruian Shi, Yan Shi, Yu-Jia Shiah, Tatsuhiro Shibata, Juliann Shih, Eigo Shimizu, Kiyo Shimizu, Seung Jun Shin, Yuichi Shiraishi, Tal Shmaya, Ilya Shmulevich, Solomon I. Shorser, Charles L. Short, Suyash Shringarpure, Craig D. Shriver, Reiner Siebert, Anieta M. Sieuwerts, Sabina Signoretti, Katarzyna Otylia Sikora, Michele Simbolo, Ronald Simon, Janae V. Simons, Jared T. Simpson, Peter T. Simpson, Samuel Singer, Payal Sipahimalani, Tara J. Skelly, Marcel Smid, Jaclyn Smith, Karen Smith‐McCune, Nicholas D. Socci, Heidi J. Sofia, Matthew G. Soloway, Lei Song, Anil K. Sood, Sharmila Sothi, Christos P. Sotiriou, Cameron M. Soulette, Paul N. Span, Paul T. Spellman, Nicola Sperandio, Andrew John Spillane, Oliver G. Spiro, Jonathan Spring, Johan Staaf, Peter Florian Stadler, Peter Staib, Stefan G. Stark, Lucy A. Stebbings, Ólafur Andri Stefánsson, Oliver Stegle, Alasdair Stenhouse, Chip Stewart, Stephan Stilgenbauer, Miranda D. Stobbe, Michael R. Stratton, Jonathan R. Stretch, Adam J. Struck, Henk G. Stunnenberg, Hong Lin Su, Xiaoping Su, Ren Sun, Stéphanie Sungalee, Hana Sušak, Akihiro Suzuki, Fred C.G.J. Sweep, Monika Szczepanowski, Holger Sültmann, Takashi Yugawa, Angela Tam, Benita Kiat Tee Tan, Donghui Tan, Patrick B. O. Tan, Hiroko Tanaka, Hirokazu Taniguchi, Tomas J. Tanskanen, Maxime Tarabichi, Roy W Tarnuzzer, Patrick S. Tarpey, Morgan L. Taschuk, Kenji Tatsuno, Simon Tavaré, Darrin F. Taylor, Amaro N Taylor-Weiner, Jon W. Teague, Bin Tean Teh, Varsha Tembe, Javier Temes, Kevin Eric Thai, Sarah P. Thayer, Nina Thiessen, Gilles Thomas, Sarah Thomas, Alan C. Thompson, Alastair Mark Thompson, John F. Thompson, R. Houston Thompson, Heather Thorne, Leigh B. Thorne, Adrian Thorogood, Nebojša Tijanić, Lee E. Timms, Roberto Tirabosco, Marta Tojo, Stefania Tommasi, Christopher W. Toon, Umut H. Toprak, David Torrents, Giampaolo Tortora, Jörg Tost, Yasushi Totoki, David M. R. Townend, Nadia Traficante, Isabelle Treilleux, Jean-Rémi Trotta, Lorenz H. P. Trümper, Ming‐Sound Tsao, José M. C. Tubío, Olga Tucker, Richard Calvin Turkington, Daniel J. Turner, Andrew N.J. Tutt, Masaki Ueno, Naoto Tada Ueno, Christopher B. Umbricht, Tim Underwood, Lara Urban, Tomoko Urushidate, Tetsuo Ushiku, David Van Den Berg, Steven Van Laere, Peter Van Loo, Erwin G. Van Meir, Gert G. Van den Eynden, Theodorus van der Kwast, Naveen S. Vasudev, Ravikiran Vedururu, Umadevi Veluvolu, Shankar Vembu, Peter Vermeulen, Clare L. Verrill, Alain Viari, David J. Vicente, Caterina Vicentini, K. VijayRaghavan, Juris Vīksna, Ricardo E. Vilain, Izar Villasante, Anne Vincent‐Salomon, Tapio Visakorpi, Douglas Voet, Paresh Vyas, Ignacio Vázquez-Garćıa, Nick M. Waddell, Nicola Waddell, Rabea Wagener, Jeremiah A. Wala, Jian Wang, Linghua Wang, Qi Wang, Wenyi Wang, Yumeng Wang, Zhining Wang, Paul Waring, Hans-Jörg Warnatz, Anne Yvonne Warren, David C. Wedge, Dieter Weichenhan, Paul Weinberger, John N. Weinstein, Daniel J. Weisenberger, Ian Welch, Michael C. Wendl, Johannes Werner, Justin P. Whalley, Hayley C. Whitaker, Dennis A. Wigle, Matthew D. Wilkerson, Ashley A. Williams, James S. Wilmott, Gavin W. Wilson, Julie M. Wilson, Richard K. Wilson, Boris J. N. Winterhoff, Jeffrey A. Wintersinger, Maciej Wiznerowicz, Stephan Wolf, Bernice Huimin Wong, Tina Tzee Ling Wong, Winghing Wong, Youngchoon Woo, Scott Wood, Bradly G. Wouters, A. Jordan Wright, Derek Wright, Mark H. Wright, Chin‐Lee Wu, Dai‐Ying Wu, Jianmin Wu, Kui Wu, Yang Wu, Zhenggang Wu, Xi Liu, Tian Xia, Qian Xiang, Xiao Xiao, Rui Xing, Heng Xiong, Qinying Xu, Yanxun Xu, Hong Xue, Shinichi Yachida, Sergei Yakneen, Takafumi N. Yamaguchi, Masakazu Yamamoto, Shogo Yamamoto, Hiroki Yamaue, Fan Yang, Huanming Yang, Jean Yee Hwa Yang, Liming Yang, Lixing Yang, Shanlin Yang, Tsun-Po Yang, Yang Yang, Marie‐Laure Yaspo, Lucy R. Yates, Christina S. F. Yau, Chen Ye, Kai Ye, Venkata D. Yellapantula, Christopher J. Yoon, Sung-Soo Yoon, Fouad Yousif, Kaixian Yu, Willie Yu, Yingyan Yu, Ke Yuan, Yuan Yuan, Denis Yuen, Christina K. Yung, Olga Zaikova, Jorge Zamora, Marc Zapatka, Jean Claude Zenklusen, Thorsten Zenz, Nikolajs Zeps, Cheng‐Zhong Zhang, Fan Zhang, Hailei Zhang, Hongwei Zhang, Hongxin Zhang, Jiashan Zhang, Junjun Zhang, Xiuqing Zhang, Yan Zhang, Zemin Zhang, Liangtao Zheng, Xiuqing Zheng, Wanding Zhou, Yong Hong Zhou, Bin Zhu, Hongtu Zhu, Jingchun Zhu, Shida Zhu, Xueqing Zou, Anna DeFazio, Nicholas J. van As, Carolien H. M. van Deurzen, Marc J. van de Vijver, L. van’t Veer

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Le résumé fourni par la source

Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pathways and additional cancer genes with infrequent mutations. We also analyzed prognostic molecular pathways by integrating genomic and transcriptomic features of 1780 breast cancers and highlighted associations with immune response and anti-apoptotic signaling. Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal human tissues identified processes of tissue regeneration and stem cell regulation. ActivePathways is a versatile method that improves systems-level understanding of cellular organization in health and disease through integration of multiple molecular datasets and pathway annotations.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Integrative pathway enrichment analysis of multivariate omics data
Date Crossref: 05/02/2020
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Ontario Institute for Cancer Research Computational Biology Program pays non établi dans la notice
Organisme public
University of Toronto Department of Medical Biophysics pays non établi dans la notice
Université ou école supérieure
University of California Broad Stem Cell Research Centre pays non établi dans la notice
Université ou école supérieure
Canada Research Chairs pays non établi dans la notice
Organisme public
Broad Center pays non établi dans la notice
Organisation à but non lucratif
Precision Research (United States) pays non établi dans la notice
Entreprise
Wellcome Sanger Institute pays non établi dans la notice
Organisation à but non lucratif
The University of Texas MD Anderson Cancer Center Department of Genomic Medicine pays non établi dans la notice
Établissement de santé
Baylor College of Medicine Quantitative & Computational Biosciences Graduate Program pays non établi dans la notice
Université ou école supérieure
Quantitative BioSciences pays non établi dans la notice
Organisation à but non lucratif
Jackson Laboratory pays non établi dans la notice
Organisation à but non lucratif
The Jackson Laboratory for Genomic Medicine pays non établi dans la notice
Organisation à but non lucratif

Computational Biology Program — Ontario Institute for Cancer Research, Department of Medical Biophysics — University of Toronto et Broad Stem Cell Research Centre — University of California, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Hippo pathway signaling and YAP/TAZRNA Research and SplicingBioinformatics and Genomic Networks

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