Accès ouvert déclaré 2020 article

The evolutionary history of 2,658 cancers

Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C. Dentro, Daniel Rosebrock, Thomas J. Mitchell, Yulia Rubanova, Pavana Anur, Amit G. Deshwar, Jeff A. Wintersinger, Kortine Kleinheinz, Ignacio Vázquez-Garćıa, Kerstin Haase, Salem Malikić, Dimitri G. Livitz, Marek Cmero, Steven E. Schumacher, Yu Fan, Xiaotong Yao, Juhee Lee, Matthias Schlesner, David D.L. Bowtell, Gad A. Getz, Marcin B. Imielinski, Rameen Beroukhim, S. Cenk Şahinalp, Martin Peifer, Wenyi Wang, Geoff Macintyre, Paul Christopher Boutros, Peter J. Campbell, Shaolong Cao, Elizabeth L. Christie, Yupeng Cun, Kevin J. Dawson, Nilgun Donmez, Ruben M. Drews, Roland Eils, Matthew W. Fittall, Dale W. Garsed, Gavin Ha, Lara Jerman, Yuan Ji, Henry Lee-Six, Florian M. Markowetz, Iñigo Martincorena, Ville Mustonen, Layla Oesper, Myron Peto, Benjamin J. Raphael, Adriana Salcedo, Ruian Shi, Seung Jun Shin, Lincoln D. Stein, Shankar Vembu, David A. Wheeler, Tsun-Po Yang, Xiaotong Yao, Ke Yuan, Peter Van Loo, Paul T. Spellman, Lauri A. Aaltonen, Federico Abascal, Adam Abeshouse, Hiroyuki Aburatani, Nishant Agrawal, Keun Soo Ahn, Sung-Min Ahn, Hiroshi Aikata, Rehan Akbani, Kadir Caner Akdemir, Hikmat A Al‐Ahmadie, Sultan T. Al‐Sedairy, Fátima Al‐Shahrour, Malik Alawi, Monique Albert, Kenneth Aldape, Ludmil B. Alexandrov, Adrian Ally, Kathryn Alsop, Eva G. Álvarez, Fernanda M Amary, Samirkumar B. Amin, Brice Aminou, Ole Ammerpohl, Matthew J. Anderson, Yeng Shiong Ang, Davide Antonello, Samuel A. J. R. Aparicio, Elizabeth L. Appelbaum, Yasuhito Arai, Axel Aretz, Koji Arihiro, Shun‐ichi Ariizumi, Joshua Armenia, Laurent Arnould, Sylvia L. Asa, Yassen Assenov, Gurnit Atwal, Sietse Aukema, J. Todd Auman, Miriam R. R. Aure, Philip Awadalla, Marta Aymerich, Gary D. Bader, Adrian Baez‐Ortega, Matthew H. Bailey, Peter J. Bailey, Miruna Balasundaram, Saianand Balu, Pratiti Bandopadhayay, Rosamonde Elizabeth Banks, Stefano Barbi, Andrew P. Barbour, Jonathan Barenboim, Jill S. Barnholtz‐Sloan, Hugh Barr, Elisabet Barrera, John A Bartlett, Javier Bartolomé, Claudio Bassi, Oliver F. Bathe, Daniel Baumhoer, Prashant P. Bavi, Stephen B. Baylin, Wojciech Bażant, Duncan Beardsmore, Tim Beck, Sam Behjati, Andreas Behren, Beifang Niu, Cindy Bell, Sergi Beltrán, Christopher C. Benz, Andrew Berchuck, Anke Katharina Bergmann, Erik N. Bergstrom, Benjamin Paul Berman, Daniel Maurice Berney, Mario Berríos, Samantha Bersani, Johanna Bertl, Miguel Betancourt, Vinayak Bhandari, Shriram G. Bhosle, Andrew Victor Biankin, Matthias Bieg, Darell D. Bigner, Hans Binder, Ewan Birney, Michael J. Birrer, Nidhan K. Biswas, Bodil Bjerkehagen, Tom Bodenheimer, Lori Boice, Giada Bonizzato, Johann Sebastian De Bono, Arnoud Boot, Åke Borg, Arndt Borkhardt, Keith A. Boroevich, Ivan Borozan, Christoph W. Borst, Marcus Bosenberg, Mattia Bosio, Jacqueline Boultwood, Guillaume Bourque, G. Steven Bova, David Bowen, Reanne Bowlby, Sandrine Boyault, Rich Boyce, Jeffrey M. Boyd, Alvis Brāzma, Paul E. Brennan, Daniel S. Brewer, Arie B. Brinkman, Robert Glen Bristow, Russell R. Broaddus, Jane E. Brock, Malcolm V. Brock, Annegien Broeks, Angela Norie Brooks, Denise Brooks, Benedikt Brors, Søren Brunak, Timothy J. C. Bruxner, Alicia L. Bruzos, Alex Buchanan, Ivo Buchhalter, Christiane Buchholz, Susan Bullman, Hazel Burke, Birgit Burkhardt, Kathleen H. Burns, John P. Busanovich, Carlos D. Bustamante, Adam P. Butler, Atul Janardhan Butte, Niall J. Byrne, Anne‐Lise Børresen‐Dale, Rory Johnson, Andy Cafferkey, Declan J. Cahill, Claudia Calabrese, Carlos H. Caldas, Fabien M. Calvo, Niedzica Camacho, Elı́as Campo, Cinzia Cantù, Thomas E. Carey, Joana Carlevaro-Fita, Rebecca Birch Carlsen, Ivana Cataldo, Mario Cazzola, Jonathan Simon Cebon, Robert Cerfolio, Dianne E. Chadwick, Dimple Chakravarty, Drc Chalmers, Calvin Wing Yiu Chan, Kin Chan, Michelle Chan Seng Yue, Vishal Suresh Chandan, David Kuang-Fu Chang, Stephen Jacob Chanock, Aurélien Chateigner, Nilanjan Chatterjee, Kazuaki Chayama, Hsiao-Wei Chen, Jieming Chen, Ken Chen, Yiwen Chen, Zhaohong Chen, Andrew D. Cherniack, JEREMY R. CHIEN, Yoke-Eng Chiew, Suet‐Feung Chin, Juok Cho, Sunghoon Cho, Jung Kyoon Choi, Wan Choi, Christine Chomienne, Zechen Chong, Su Pin Choo, Angela S. Y. Chou, Angelika N. Christ, Eric Chuah, Carrie Cibulskis, Kristian Cibulskis, Sara Cingarlini, Peter Clapham, Alexander Claviez, Sean Patrick Cleary, Nicole Cloonan, Colin C. Collins, Ashton Anthony Connor, Susanna L. Cooke, Colin S. Cooper, Leslie Cope, Vincenzo Corbo, Matthew G. Cordes, Stephen M. Cordner, Isidro Cortés‐Ciriano, Kyle R. Covington, Prue A. Cowin, Brian Craft, David Craft, Chad J. Creighton, Erin E. Curley, Ioana Cutcutache, Karolina M. Czajka, Bogdan A. Czerniak, Rebecca A. Dagg, Ludmila Danilova, Maria Vittoria Davì, Natalie R. Davidson, Helen W. Davies, Ian J. Davis, Brandi N. Davis‐Dusenbery, Francisco M. De La Vega, Ricardo De Paoli‐Iseppi, Timothy Defreitas, Angelo Paolo Dei Tos, Olivier Delaneau, John A. Demchok, Jonas Demeulemeester, German M. Demidov, Deniz Demircioğlu, Nening M. Dennis, Robert Edward Denroche, Nikita Desai, Vikram Deshpande, Christine Desmedt, Jordi Deu-Pons, Noreen Dhalla, Neesha C. Dhani, Priyanka Dhingra, Rajiv Dhir, Anthony DiBiase, Klev Diamanti, Li Ding, Huy Q. Dinh, Luc Yves Dirix, HarshaVardhan Doddapaneni, Michelle T. Dow, Ronny Drapkin, Oliver Drechsel, Serge Serge, Tim J. Dudderidge, Ana Dueso-Barroso, Andrew J Dunford, Michael James Dunn, Lewis Jonathan Dursi, Fraser R. Duthie, Ken Dutton‐Regester, Jenna Eagles, Douglas F. Easton, Stuart D. Edmonds, Paul Alan Edwards, Sandra E. Edwards, Rosalind A. Eeles, Anna Ehinger, Adel K. El‐Naggar, Matthew Eldridge, Kyle Ellrott, Serap Erkek, Geòrgia Escaramís, Shadrielle M. G. Espiritu, Xavier Estivill, Dariush Etemadmoghadam, Jorunn Erla Eyfjord, Bishoy M. Faltas, Daiming Fan, William C. Faquin, Claudiu Farcas, Matteo Fassan, Aquila Fatima, Francesco Favero, Nodirjon Fayzullaev, Ina Felau, Sián Fereday, Martin L. Ferguson, Vincent Ferretti, Lars Feuerbach, Matthew A. Field, J. Lynn Fink, Gaetano Finocchiaro, Cyril Fisher, Anna M. Fitzgerald, Rebecca C. Fitzgerald, Adrienne Margaret Flanagan, Neil Eric Fleshner, Paul Flicek, John A. Foekens, Kwun Meng Fong, Nuno A. Fonseca, Christopher S. Foster, Natalie S. Fox, Michael E. Fraser, Scott Frazer, Milana Frenkel‐Morgenstern, William A. Friedman, Joan Frigola, Catrina C. Fronick, Akihiro Fujimoto, Masashi Fujita, Masashi Fukayama, Lucinda A. Fulton, Robert S. Fulton, Mayuko Furuta, P. Andrew Futreal, Anja Füllgrabe, Stacey L. Gabriel, Steven N. Gallinger, Carlo B Gambacorti-Passerini, Jianjiong Gao, Shengjie Gao, Levi A. Garraway, Øystein Garred, Erik P. Garrison, Nils Gehlenborg, Josep L. L. Gelpi, Joshy George, Daniela Se Gerhard, Clarissa Gerhäuser, Mark Gerstein, Mohammed Ghori, Ronald A. Ghossein, Nasra H. Giama, Richard A. Gibbs, Bob Gibson, Anthony James Gill, Pelvender Gill, Dilip D. Giri, Dominik Głodzik, Vincent J. Gnanapragasam, Maria Elisabeth Goebler, Mary J. Goldman, Carmen Elena Gómez, Santiago González, Abel González-Pérez, Dmitry A. Gordenin, James Gossage, Kunihito Gotoh, Ramaswamy Govindan, Dorthe Aamand Grabau, Janet Shirley Graham, Robert C. Grant, Anthony Richard Green, Eric P Green, Liliana Greger, Nicola Grehan, Sonia Grimaldi, Sean Michael Grimmond, Robert L. Grossman, Adam T. Grundhoff, Gunes Gundem, Qianyun Guo, Manaswi Gupta, Shailja Gupta, Ivo Glynne Gut, Jonathan Göke, Andrea Haake, David Haan, Siegfried Haas, James E. Haber, Faraz Hach, Syed W. Haider, Natsuko Hama, Freddie Charles Hamdy, Anne L. Hamilton, Mark P. Hamilton, Leng Han, George B. Hanna, Martin Hansmann, Nicholas J. Haradhvala, Olivier Harismendy, Ivon Harliwong, Arif O. Harmanci, Eoghan Harrington, Takanori Hasegawa, David H. Haussler, Steve F. C. Hawkins, Shinya Hayami, Shuto Hayashi, D. Neil Hayes, Stephen J. Hayes, Nicholas K. Hayward, Steven Hazell, Allison P. Heath, Simon Charles Heath, David William Hedley, Apurva M. Hegde, David I. Heiman, Michael C. Heinold, Zachary J. Heins, Lawrence E. Heisler, Eva Hellstrom-Lindberg, Mohamed E. HELMY, Seong Gu Heo, Austin J. Hepperla, José María Heredia‐Genestar, Carl Herrmann, Peter Hersey, Julian M. Hess, Hólmfríður Hilmarsdóttir, Jonathan Hinton, Satoshi Hirano, Nobuyoshi Hiraoka, Katherine A. Hoadley, Asger Hobolth, Ermin Hodzic, Jessica I. Hoell, Steve Hoffmann, Oliver Hofmann, Andrea Holbrook, Aliaksei Z. Holik, Michael Anthony Hollingsworth, Oliver Holmes, Robert A. Holt, Chen Hong, Eun Pyo Hong, Jongwhi H. Hong, Gerrit K. J. Hooijer, Henrik Hornshøj, Fumie Hosoda, Yong Hou, Volker Hovestadt, William Howat, Alan P. Hoyle, Ralph H. Hruban, Taobo Hu, Xing Hua, Kuan-lin Huang, Mei Huang, Mi Ni Huang, Vincent Huang, Yi Fei Huang, Wolfgang K. Huber, Thomas Jay Hudson, Michael Hummel, Jillian A. Hung, David George Huntsman, Ted R. Hupp, Jason T. Huse, Matthew R. Huska, Barbara Hutter, Carolyn M. Hutter, Daniel Hübschmann, Christine A. Iacobuzio–Donahue, Charles David Imbusch, Seiya Imoto, William B. Isaacs, Keren Isaev, Shumpei Ishikawa, Murat Iskar, S. M. Ashiqul Islam, Michael Ittmann, Sinisa Ivkovic, José M. G. Izarzugaza, Jocelyne D. Jacquemier, Valerie Jakrot, Nigel Balfour Jamieson, Gun Ho Jang, Se Jin Jang, Joy C. Jayaseelan, Reyka G. Jayasinghe, Karine Jegalian, Jennifer L. Jennings, Seung-Hyup Jeon, Wei Jiao, Peter A. Johansson, Amber L. Johns, Jeremy Johns, Todd A. Johnson, Yann Joly, Jon Gunnlaugur Jonasson, Corbin D. Jones, David Randolph Jones, David Jones, Nic Jones, Steven J.M. Jones, Jos Jonkers, Young Seok Ju, Hartmut H. Juhl, Jongsun Jung, Malene Juul, Randi Istrup Juul, Natalie Jäger, Rolf Kabbe, André Kahles, Abdullah Kahraman, Vera B. Kaiser, Hojabr Kakavand, Sangeetha N. Kalimuthu, Christof V. Kalle, Koo Jeong Kang, Katalin Karászi, Beth Y. Karlan, Rosa Karlić, Dennis Karsch, Karin S. Kassahn, Hitoshi Katai, Mamoru Kato, Hiroto Katoh, Yoshiiku Kawakami, Jonathan D.S. Kay, Stephen H. Kazakoff, Marat D. Kazanov, Maria Keays, Electron Kebebew, Richard F. Kefford, Manolis Kellis, James G. Kench, Catherine J. Kennedy, Jules N. A. Kerssemakers, David Khoo, Vincent S Khoo, Narong Khuntikeo, Ekta Khurana, Helena Kilpinen, Hark Kyun Kim, Hyung‐Lae Kim, Hyung-Yong Kim, Hyunghwan Kim, Jihoon Kim, Jong-Kwang Kim, Young-Wook Kim, Tari A. King, Leszek J. Klimczak, Stian Knappskog, Michael Kneba, Bartha Maria Knoppers, Youngil Koh, Jan Komorowski, Daisuke Komura, Mitsuhiro Komura, Gu Kong, Marcel Kool, Jan O. Korbel, Viktoriya Korchina, Andrey Korshunov, Michael Koscher, Roelof Koster, Zsofia Kote‐Jarai, Antonios Koures, Milena Kovačević, Bárbara Kremeyer, Helene Kretzmer, Markus Kreuz, Savitri Krishnamurthy, Dieter Kube, Kiran Kumar, Pardeep Kumar, Sushant Kumar, Yogesh Kumar, Ritika Kundra, Kirsten Kübler, Ralf Küppers, Jesper Lagergren, Phillip H. Lai, Peter W. Laird, Sunil R. Lakhani, Christopher M. Lalansingh, Emilie Lalonde, Fabien Claude Lamaze, Adam M. Lambert, Eric Lander, Pablo Landgraf, Luca Landoni, Anita Langerød, Andrés Lanzós, Denis Larsimont, Erik Larsson, Mark Lathrop, Loretta M. S. Lau, Chris Lawerenz, Rita Teresa Lawlor, Michael S. Lawrence, Alexander J. Lazar, Ana Mijalkovic Lazic, Xuan Le, Darlene Lee, Donghoon Lee, Eunjung Alice Lee, Hee Jin Lee, Jake June-Koo Lee, Jeong‐Yeon Lee, Ming Ta Michael Lee, Kjong-Van Lehmann, Hans R. Lehrach, Dido Lenze, Conrad Leonard, Daniel A. Leongamornlert, Louis Létourneau, Ivica Letunić, Douglas A. Levine, Lora R Lewis, Tim Ley, Constance H. Li, Haiyan Irene Li, Jun Li, Lin Li, Shantao Li, Siliang Li, Xiaobo Li, Xiaotong Li, Xinyue Li, Yilong Li, Han Liang, Sheng‐Ben Liang, Péter Lichter, Pei Yi Lin, Ziao Lin, W. M. Linehan, Ole Christian Lingjærde, Dongbing Liu, Eric Minwei Liu, Fei-Fei Fei Liu, Fenglin Liu, Jia Liu, Xingmin Liu, Julie M. Livingstone, Naomi Livni, Lucas Lochovsky, Markus Loeffler, Georgina Venetia Long, Armando López‐Guillermo, Shaoke Lou, David N. Louis, Laurence B. Lovat, Yiling Lu, Yong‐Jie Lu, Youyong Lu, Claudio Luchini, Ilinca M. Lungu, Xuemei Luo, Hayley J. Luxton, Andy G. Lynch, Lisa Lype, Cristina López, Carlos López-Otı́n, Eric Z. Ma, Yussanne Ma, Gaëtan Marie MacGrogan, Shona MacRae, Tobias Lynge Madsen, Kazuhiro Maejima, Andrea Mafficini, Dennis T. Maglinte, Arindam Maitra, Partha P. Majumder, Luca Malcovati, Giuseppe Malleo, Graham J. Mann, Luisa Mantovani‐Löffler, Kathleen Marchal, Giovanni Marchegiani, Elaine R. Mardis, Adam A. Margolin, Maximillian G. Marin, Julia Markowski, Jeffrey S. Marks, Tomàs Marquès‐Bonet, Marco A. Marra, Luke Marsden, John W.M. Martens, Sancha Martin, José Ignacio Martín-Subero, Alexander Martinez‐Fundichely, Yosef E. Maruvka, R. Jay Mashl, Charles E. Massie, Thomas J. Matthew, Lucy Matthews, Erik Mayer, Simon Mayes, Michael A. Mayo, Faridah Mbabaali, Karen Smith McCune, Ultan McDermott, Patrick D. McGillivray, Michael D. McLellan, John D. McPherson, John R. McPherson, Treasa A. McPherson, Samuel R. Meier, Alice Meng, Shaowu Meng, Andrew H. Menzies, Neil Donald Merrett, Sue Merson, Matthew Meyerson, William Meyerson, Piotr A. Mieczkowski, George L. Mihaiescu, Sanja Mijalković, Tom Mikkelsen, Michele Stanislaw Milella, Linda Mileshkin, Christopher A. Miller, David K. Miller, Jessica K. Miller, Gordon Brent Mills, Ana Milovanovic, Sarah Jane Pauline Minner, Marco Miotto, Gisela Mir Arnau, Satoru Miyano, Naoki Miyoshi, Shinichi Mizuno, Fruzsina Molnár‐Gábor, Malcolm J. Moore, Richard A. Moore, Sandro Morganella, Quaid Morris, Lisle E. Mose, Catherine D. Moser, Ferran Muiños, Loris Mularoni, Andrew J. J. Mungall, Karen Mungall, Elizabeth A. Musgrove, David G. Mutch, Francesc Muyas, Donna Marie Muzny, Alfonso Muñoz, Jerome Myers, Ola Myklebost, Peter Mӧller, Genta Nagae, Adnan M. Nagrial, Hardeep K. Nahal-Bose, Hitoshi Nakagama, Hidewaki Nakagawa, Hiromi K. Nakamura, Toru Nakamura, Kaoru Nakano, Tannistha Nandi, Jyoti Nangalia, Mia Nastic, Arcadi Navarro, Fábio C. P. Navarro, David E. Neal, Gerd Nettekoven, Felicity Newell, Steven J. Newhouse, Yulia Newton, Alvin Wei Tian Ng, Anthony Ng, Jonathan Nicholson, David Nicol, Yongzhan Nie, G. Petur Nielsen, Morten Muhlig Nielsen, Serena Nik‐Zainal, Michael S. Noble, Kátia Nones, Paul A. Northcott, Faiyaz Notta, Brian D. O’Connor, Peter J. O’Donnell, Maria O’Donovan, Sarah O’Meara, Brian Patrick O’Neill, J. Robert O’Neill, David Ocaña, Angelica Ochoa, Christopher W. Ogden, Hideki Ohdan, Kazuhiro Ohi, Lucila Ohno‐Machado, Karin A. Oien, Akinyemi I. Ojesina, Hidenori Ojima, Takuji Okusaka, Larsson Omberg, Choon Kiat Ong, Stephan Ossowski, German Ott, B. F. Francis Ouellette, Christine P’ng, Marta Paczkowska, Salvatore Paiella, Chawalit Pairojkul, Marina Pajic, Qiang Pan‐Hammarström, Elli Papaemmanuil, Irene Papatheodorou, Nagarajan Paramasivam, Ji Wan Park, Joong‐Won Park, Keunchil Park, Kiejung Park, Peter J. Park, Joel S. Parker, Simon L. Parsons, Harvey Ira Pass, Danielle Pasternack, Alessandro Pastore, Ann‐Marie Patch, Iris Pauporté, Antonio Pea, John V. Pearson, Chandra Sekhar Pedamallu, Jakob Skou Pedersen, Paolo Pederzoli, Nathan A. Pennell, Charles M. Perou, Marc D. Perry, Gloria M. Petersen, Nicholas Petrelli, Robert Petryszak, Stefan M. Pfister, Mark Phillips, Oriol Pich, Hilda A. Pickett, Todd Pihl, Nischalan Pillay, Sarah E. Pinder, Mark Pinese, Andreia V. Pinho, Esa Pitkänen, Xavier Pivot, Elena Piñeiro-Yáñez, Laura Planko, Christoph Plass, Paz P Polak, Tirso Pons, Irinel Popescu, Olga Potapova, Aparna Prasad, Shaun R. Preston, Manuel Prinz, Antonia L. Pritchard, Stephenie D. Prokopec, Elena Provenzano, Xosé S. Puente, Montserrat Puiggròs, Sergio Pulido-Tamayo, Gulietta M. Pupo, Colin A. Purdie, Michael C. J. Quinn, Raquel Rabionet, Janet Sue Rader, Bernhard Radlwimmer, Petar Radovic, Benjamin Raeder, Keiran M. Raine, Manasa Ramakrishna, Kamna Ramakrishnan, Suresh S. Ramalingam, W. Kimryn Rathmell, Tobias Rausch, Guido Reifenberger, Jüri Reimand, Jorge Sergio Reis-Filho, Victor E. Reuter, Iker Reyes-Salazar, Matthew A. Reyna, Sheila M. Reynolds, Esther Rheinbay, Yasser Riazalhosseini, Andrea L. Richardson, Julia Richter, Matthew David Ringel, Markus Ringnér, Yasushi Rino, Karsten Rippe, Jeffrey M. Roach, Lewis Rowland Roberts, Nicola D. Roberts, Steven A. Roberts, A. Gordon Robertson, Alan J. Robertson, Javier Bartolomé Rodriguez, Bernardo Rodríguez–Martín, Francisco Germán Rodríguez-González, Michael H. A. Roehrl, Marius Rohde, Hirofumi Rokutan, Gilles Romieu, Ilse Rooman, Tom W. Roques, Mara W. Rosenberg, Philip C Rosenstiel, Andreas Rosenwald, Edward Rowe, Romina Royo, Steve Rozen, Mark Andrew Rubin, Carlota Rubio-Pérez, Vasilisa A. Rudneva, Borislav Chavdarov Rusev, Andrea Ruzzenente, Gunnar Rätsch, Radhakrishnan Sabarinathan, Veronica Y. Sabelnykova, Sara Sadeghi, Natalie Saini, Mihoko Saito-Adachi, Gordon Saksena, Roberto Salgado, Leonidas Salichos, Richard C. Sallari, Charles F. Saller, Roberto Salvia, Michelle Sam, Jaswinder Singh Samra, Francisco Sánchez-Vega, Chris Sander, Grant Sanders, Rajiv Sarin, Iman Sarrafi, Aya Sasaki-Oku, Torill Sauer, Guido Sauter, Robyn P.M. Saw, Maria Scardoni, Christopher James Scarlett, Aldo Scarpa, Ghislaine Scélo, Dirk Schadendorf, Jacqueline E. Schein, Markus B. Schilhabel, Thorsten Schlomm, Heather K. Schmidt, Sarah‐Jane Schramm, Stefan Schreiber, Nikolaus D. Schultz, Roland F. Schwarz, Richard A. Scolyer, David Lloyd Scott, Ralph Scully, Raja Seethala, Ayellet V. Segrè, Iris Selander, Colin A M Semple, Yasin Şenbabaoğlu, Elisabetta Sereni, Stefano Serra, Dennis C. Sgroi, Mark J. Shackleton, Nimish C Shah, Sagedeh Shahabi, Catherine A. Shang, Ping Shang, Ofer Shapira, Troy Shelton, Ciyue Shen, Hui Shen, Rebecca F. Shepherd, Yan Shi, Yu-Jia Shiah, Tatsuhiro Shibata, Juliann Shih, Eigo Shimizu, Kiyo Shimizu, Yuichi Shiraishi, Tal Shmaya, Ilya Shmulevich, Solomon I. Shorser, Charles L. Short, Raunak Shrestha, Suyash Shringarpure, Craig D. Shriver, Shimin Shuai, Nikos Sidiropoulos, Reiner Siebert, Anieta M. Sieuwerts, Lina Sieverling, Sabina Signoretti, Katarzyna O. Sikora, Michele Simbolo, Ronald Simon, Janae V. Simons, Jared T. Simpson, Peter T. Simpson, Samuel Singer, Nasa Sinnott-Armstrong, Payal Sipahimalani, Tara J. Skelly, Marcel Smid, John A. Smith, Karen Smith‐McCune, Nicholas D. Socci, Heidi J. Sofia, Matthew G. Soloway, Lei Song, Anil K. Sood, Sharmila Sothi, Christos P. Sotiriou, Cameron M. Soulette, Paul N. Span, Nicola Sperandio, Andrew John Spillane, Jonathan Spring, Johan Staaf, Peter Florian Stadler, Peter Staib, Stefan G. Stark, Lucy A. Stebbings, Ólafur Andri Stefánsson, Oliver Stegle, Alasdair Stenhouse, Chip Stewart, Stephan Stilgenbauer, Miranda D. Stobbe, Michael R. Stratton, Jonathan R. Stretch, Adam J. Struck, Joshua M. Stuart, Henk G. Stunnenberg, Hong Lin Su, Xiaoping Su, Ren Sun, Stéphanie Sungalee, Hana Sušak, Akihiro Suzuki, Fred C.G.J. Sweep, Monika Szczepanowski, Holger Sültmann, Takashi Yugawa, Angela Tam, David Tamborero, Benita Kiat Tee Tan, Donghui Tan, Patrick B. O. Tan, Hiroko Tanaka, Hirokazu Taniguchi, Tomas J. Tanskanen, Maxime Tarabichi, Roy W Tarnuzzer, Patrick S. Tarpey, Morgan L. Taschuk, Kenji Tatsuno, Simon Tavaré, Darrin F. Taylor, Amaro N Taylor-Weiner, Jon W. Teague, Bin Tean Teh, Varsha Tembe, Javier Temes, Kevin Eric Thai, Sarah P. Thayer, Nina Thiessen, Sarah K. Thomas, Alan Thompson, Alastair Mark Thompson, John F. Thompson, R. Houston Thompson, Heather Thorne, Leigh B. Thorne, Adrian Thorogood, Grace Tiao, Nebojša Tijanić, Lee E. Timms, Roberto Tirabosco, Marta Tojo, Stefania Tommasi, Christopher W. Toon, Umut H. Toprak, David Torrents, Giampaolo Tortora, Jörg Tost, Yasushi Totoki, David M. R. Townend, Nadia Traficante, Isabelle Treilleux, Jean-Rémi Trotta, Lorenz H. P. Trümper, Ming‐Sound Tsao, Tatsuhiko Tsunoda, José M. C. Tubío, Olga Tucker, Richard Calvin Turkington, Daniel J. Turner, Andrew N.J. Tutt, Masaki Ueno, Naoto Tada Ueno, Christopher B. Umbricht, Husen Muhammad Umer, Tim Underwood, Lara Urban, Tomoko Urushidate, Tetsuo Ushiku, Liis Uusküla-Reimand, Alfonso Valencia, David Van Den Berg, Steven Van Laere, Erwin G. Van Meir, Gert G. Van den Eynden, Theodorus van der Kwast, Naveen S. Vasudev, Miguel Vazquez, Ravikiran Vedururu, Umadevi Veluvolu, Peter B. Vermeulen, Clare L. Verrill, Alain Viari, David Vicente, Caterina Vicentini, K. VijayRaghavan, Juris Vīksna, Ricardo E. Vilain, Izar Villasante, Anne Vincent‐Salomon, Tapio Visakorpi, Douglas Voet, Paresh Vyas, Nick M. Waddell, Nicola Waddell, Claes Wadelius, Lina Wadi, Rabea Wagener, Jeremiah A. Wala, Jian Wang, Jiayin Wang, Linghua Wang, Qi Wang, Yumeng Wang, Zhining Wang, Paul Waring, Hans-Jörg Warnatz, Jonathan Warrell, Anne Yvonne Warren, Sebastian M. Waszak, David C. Wedge, Dieter Weichenhan, Paul Weinberger, John N. Weinstein, Joachim Weischenfeldt, Daniel J. Weisenberger, Ian D. Welch, Michael C. Wendl, Johannes Werner, Justin P. Whalley, Hayley C. Whitaker, Dennis A. Wigle, Matthew D. Wilkerson, Ashley A. Williams, James S. Wilmott, Gavin W. Wilson, Julie M. Wilson, Richard K. Wilson, Boris J. N. Winterhoff, Jeffrey A. Wintersinger, Maciej Wiznerowicz, Stephan Wolf, Bernice Huimin Wong, Tina Tzee Ling Wong, Winghing Wong, Youngchoon Woo, Scott Wood, Bradly G. Wouters, A. Jordan Wright, Derek Wright, Mark H. Wright, Chin‐Lee Wu, Dai‐Ying Wu, Guanming Wu, Jianmin Wu, Kui Wu, Yang Wu, Zhenggang Wu, Liu Xi, Tian Xia, Qian Xiang, Xiao Xiao, Rui Xing, Heng Xiong, Qinying Xu, Yanxun Xu, Hong Xue, Shinichi Yachida, Sergei Yakneen, Takafumi N. Yamaguchi, Masakazu Yamamoto, Shogo Yamamoto, Hiroki Yamaue, Fan Yang, Huanming Yang, Jean Yee Hwa Yang, Liming M Yang, Lixing Yang, Shanlin Yang, Yang Yang, Marie‐Laure Yaspo, Lucy R. Yates, Christina S. F. Yau, Chen Ye, Kai Ye, Venkata D. Yellapantula, Christopher J. Yoon, Sung-Soo Yoon, Fouad Yousif, Jun Yu, Kaixian Yu, Willie Yu, Yingyan Yu, Yuan Yuan, Denis Yuen, Christina K. Yung, Olga Zaikova, Jorge Zamora, Marc Zapatka, Jean Claude Zenklusen, Thorsten Zenz, Nikolajs Zeps, Cheng‐Zhong Zhang, Fan Zhang, Hailei Zhang, Hongwei Zhang, Hongxin Zhang, Jiashan Zhang, Jing Zhang, Junjun Zhang, Xiuqing Zhang, Xuanping Zhang, Yan Zhang, Zemin Zhang, Zhongming Zhao, Liangtao Zheng, Xiuqing Zheng, Wanding Zhou, Yong Hong Zhou, Bin Zhu, Hongtu Zhu, Jingchun Zhu, Shida Zhu, Lihua Zou, Xueqing Zou, Anna DeFazio, Nicholas J. van As, Carolien H. M. van Deurzen, Marc J. van de Vijver, L. van’t Veer, Christian von Mering

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Rattachement africain : gb, ru, de, us, ca, si, au, be, fi, kr, jp, sa, es, no, cn, il, dk, mx, in, sg, se, fr, nl, ch, it, nz, is, pt, hk, hr, th, pl, tw, ro, ee, lv. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Abstract Cancer develops through a process of somatic evolution 1,2 . Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes 3 . Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) 4 , we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number gains, such as trisomy 7 in glioblastoma and isochromosome 17q in medulloblastoma. The mutational spectrum changes significantly throughout tumour evolution in 40% of samples. A nearly fourfold diversification of driver genes and increased genomic instability are features of later stages. Copy number alterations often occur in mitotic crises, and lead to simultaneous gains of chromosomal segments. Timing analyses suggest that driver mutations often precede diagnosis by many years, if not decades. Together, these results determine the evolutionary trajectories of cancer, and highlight opportunities for early cancer detection.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref
The evolutionary history of 2,658 cancers
Date Crossref
05/02/2020
Éditeur
Springer Science and Business Media LLC
Type
journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

  • European Bioinformatics Institute pays non établi dans la notice
    Structure de recherche
  • Wellcome Sanger Institute pays non établi dans la notice
    Organisation à but non lucratif
  • Bioinformatics Institute pays non établi dans la notice
    Organisation à but non lucratif
  • European Molecular Biology Laboratory pays non établi dans la notice
    Organisme public
  • The Francis Crick Institute pays non établi dans la notice
    Structure de recherche
  • Broad Institute pays non établi dans la notice
    Organisation à but non lucratif
  • Open Data Institute pays non établi dans la notice
    Organisation à but non lucratif
  • University of Oxford Big Data Institute pays non établi dans la notice
    Université ou école supérieure
  • University of Cambridge Cancer Research UK Cambridge Institute pays non établi dans la notice
    Université ou école supérieure
  • University of Toronto pays non établi dans la notice
    Université ou école supérieure
  • Vector Institute pays non établi dans la notice
    Structure de recherche
  • Oregon Health & Science University Molecular and Medical Genetics pays non établi dans la notice
    Université ou école supérieure

European Bioinformatics Institute, Wellcome Sanger Institute et Bioinformatics Institute, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Cancer Genomics and DiagnosticsGenetic factors in colorectal cancerDNA Repair Mechanisms
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