Accès ouvert déclaré
2020
article
Combined burden and functional impact tests for cancer driver discovery using DriverPower
Shimin Shuai, Federico Abascal, Samirkumar B. Amin, Gary D. Bader, Pratiti Bandopadhayay, Rameen Beroukhim, Johanna Bertl, Keith A. Boroevich, Joana Carlevaro-Fita, Dimple Chakravarty, Jung Kyoon Choi, Lars Feuerbach, Nuno A. Fonseca, Joan Frigola, Carlo Gambacorti‐Passerini, Dale W. Garsed, Mark Gerstein, Marta Gut, David Haan, Mark P. Hamilton, Nicholas J. Haradhvala, Mohamed Helmy, Carl Herrmann, Asger Hobolth, Hong Chen, Keren Isaev, José M. G. Izarzugaza, Todd A. Johnson, André Kahles, Abdullah Kahraman, Manolis Kellis, Ekta Khurana, Jong-Kwang Kim, Young-Wook Kim, Jan Komorowski, Jan O. Korbel, Andrés Lanzós, Erik G. Larsson, Michael S. Lawrence, Shantao Li, Xiaotong Li, Lucas Lochovsky, Tobias Madsen, Kathleen Marchal, Iñigo Martincorena, Alexander Martinez‐Fundichely, Yosef E. Maruvka, Patrick D. McGillivray, Ferran Muiños, Loris Mularoni, Hidewaki Nakagawa, Morten Muhlig Nielsen, Marta Paczkowska, Keunchil Park, Tirso Pons, Sergio Pulido-Tamayo, Benjamin J. Raphael, Iker Reyes-Salazar, Esther Rheinbay, Mark A. Rubin, Carlota Rubio-Pérez, S. Cenk Şahinalp, Leonidas Salichos, Steven E. Schumacher, Mark Shackleton, Ofer Shapira, Ciyue Shen, Raunak Shrestha, Nikos Sidiropoulos, Nasa Sinnott-Armstrong, Joshua M. Stuart, Grace Tiao, Tatsuhiko Tsunoda, Husen M. Umer, Liis Uusküla-Reimand, Claes Wadelius, Jiayin Wang, Jonathan Warrell, Sebastian M. Waszak, Jing Zhang, Xuanping Zhang, Zhongming Zhao, Lihua Zou, Steven Gallinger, Lauri A. Aaltonen, Adam Abeshouse, Hiroyuki Aburatani, David J. Adams, Nishant Agrawal, Keun Soo Ahn, Sung-Min Ahn, Hiroshi Aikata, Rehan Akbani, Kadir C. Akdemir, Hikmat Al‐Ahmadie, Sultan T. Al‐Sedairy, Fátima Al‐Shahrour, Malik Alawi, Monique Albert, Kenneth Aldape, Ludmil B. Alexandrov, Adrian Ally, Kathryn Alsop, Eva G. Álvarez, Fernanda Amary, Brice Aminou, Ole Ammerpohl, Matthew J. Anderson, Yeng Ang, Davide Antonello, Pavana Anur, Samuel Aparício, Elizabeth L. Appelbaum, Yasuhito Arai, Axel Aretz, Koji Arihiro, Shun‐ichi Ariizumi, Joshua Armenia, Laurent Arnould, L. Sylvia, Yassen Assenov, Gurnit Atwal, Sietse Aukema, J. Todd Auman, Miriam R. R. Aure, Philip Awadalla, Marta Aymerich, Adrian Baez‐Ortega, Peter J. Bailey, Miruna Balasundaram, Saianand Balu, Rosamonde E. Banks, Stefano Barbi, Andrew P. Barbour, Jill S. Barnholtz‐Sloan, Hugh Barr, Elisabet Barrera, John G. Bartlett, Javier Bartolomé, Claudio Bassi, Oliver F. Bathe, Daniel Baumhoer, Prashant Bavi, Stephen B. Baylin, Wojciech Bażant, Duncan Beardsmore, Tim Beck, Sam Behjati, Andreas Behren, Beifang Niu, Cindy Bell, Sergi Beltrán, Christopher C. Benz, Andrew Berchuck, Anke K. Bergmann, Erik N. Bergstrom, Benjamin P. Berman, Daniel M. Berney, Rameen Beroukhim, Mario Berríos, Samantha Bersani, Miguel Betancourt, Vinayak Bhandari, Shriram G. Bhosle, Andrew V. Biankin, Matthias Bieg, Darell D. Bigner, Hans Binder, Ewan Birney, Michael Birrer, Nidhan K. Biswas, Bodil Bjerkehagen, Tom Bodenheimer, Lori Boice, Giada Bonizzato, Johann S. de Bono, Arnoud Boot, Åke Borg, Arndt Borkhardt, Ivan Borozan, Christoph W. Borst, Marcus Bosenberg, Mattia Bosio, Jacqueline Boultwood, Guillaume Bourque, Paul C. Boutros, G. Steven Bova, David Bowen, Reanne Bowlby, David D.L. Bowtell, Sandrine Boyault, Rich Boyce, Jeffrey M. Boyd, Alvis Brāzma, Paul M. Brennan, Daniel S. Brewer, Arie B. Brinkman, Robert G. Bristow, Russell R. Broaddus, Jane E. Brock, Malcolm V. Brock, Annegien Broeks, Angela N. Brooks, Denise Brooks, Benedikt Brors, Timothy J. C. Bruxner, Alicia L. Bruzos, Alex Buchanan, Ivo Buchhalter, Christiane Buchholz, Susan Bullman, Hazel Burke, Birgit Burkhardt, Kathleen H. Burns, John Busanovich, Carlos D. Bustamante, Adam P. Butler, Atul J. Butte, Niall J. Byrne, Anne‐Lise Børresen‐Dale, Rory Johnson, Andy Cafferkey, Declan Cahill, Claudia Calabrese, Carlos Caldas, Fabien Calvo, Niedzica Camacho, Elı́as Campo, Cinzia Cantù, Shaolong Cao, Thomas E. Carey, Rebecca Carlsen, Ivana Cataldo, Mario Cazzola, Jonathan Cebon, Robert Cerfolio, Dianne Chadwick, Drc Chalmers, Kin Chan, Michelle Chan‐Seng‐Yue, Vishal S. Chandan, David K. Chang, Stephen J. Chanock, Aurélien Chateigner, Nilanjan Chatterjee, Kazuaki Chayama, Hsiao‐Wei Chen, Jieming Chen, Yiwen Chen, Zhaohong Chen, Andrew D. Cherniack, Jeremy Chien, Yoke-Eng Chiew, Suet‐Feung Chin, Juok Cho, Sunghoon Cho, Wan Choi, Christine Chomienne, Zechen Chong, Su Pin Choo, Angela Chou, Angelika N. Christ, Elizabeth L. Christie, Eric Chuah, Carrie Cibulskis, Kristian Cibulskis, Sara Cingarlini, Peter Clapham, Alexander Claviez, Sean P. Cleary, Nicole Cloonan, Marek Cmero, Colin C. Collins, Ashton A. Connor, Susanna L. Cooke, Colin S. Cooper, Leslie Cope, Vincenzo Corbo, Matthew G. Cordes, Stephen Cordner, Isidro Cortés‐Ciriano, Kyle R. Covington, Prue A. Cowin, Brian Craft, David Craft, Chad J. Creighton, Yupeng Cun, Erin Curley, Ioana Cutcutache, Karolina Czajka, Bogdan Czerniak, Rebecca A. Dagg, Ludmila Danilova, Maria Vittoria Davì, Natalie R. Davidson, Helen Davies, Ian J. Davis, Brandi N. Davis‐Dusenbery, Kevin J. Dawson, Francisco M. De La Vega, Ricardo De Paoli‐Iseppi, Timothy Defreitas, Angelo Paolo Dei Tos, Olivier Delaneau, John A. Demchok, Jonas Demeulemeester, German Demidov, Deniz Demircioğlu, Nening M. Dennis, Robert E. Denroche, Stefan C. Dentro, Nikita Desai, Vikram Deshpande, Amit G. Deshwar, Christine Desmedt, Noreen Dhalla, Neesha C. Dhani, Rajiv Dhir, Anthony DiBiase, Li Ding, Huy Q. Dinh, Luc Dirix, HarshaVardhan Doddapaneni, Nilgun Donmez, Michelle T. Dow, Ronny Drapkin, Oliver Drechsel, Ruben M. Drews, Serge Serge, Tim Dudderidge, Ana Dueso-Barroso, Andrew Dunford, Michael Dunn, Lewis Jonathan Dursi, Fraser R. Duthie, Ken Dutton‐Regester, Jenna Eagles, Douglas F. Easton, Stuart Edmonds, Paul A. Edwards, Sandra E. Edwards, Rosalind A. Eeles, Anna Ehinger, Roland Eils, Adel K. El‐Naggar, Matthew Eldridge, Kyle Ellrott, Serap Erkek, Geòrgia Escaramís, Shadrielle M. G. Espiritu, Xavier Estivill, Dariush Etemadmoghadam, Jorunn E. Eyfjord, Bishoy M. Faltas, Daiming Fan, Yu Fan, William C. Faquin, Claudiu Farcas, Matteo Fassan, Aquila Fatima, Francesco Favero, Nodirjon Fayzullaev, Ina Felau, Sián Fereday, Martin L. Ferguson, Vincent Ferretti, Matthew A. Field, Gaetano Finocchiaro, Cyril Fisher, Matthew W. Fittall, Anna Fitzgerald, Rebecca C. Fitzgerald, Adrienne M. Flanagan, Neil Fleshner, Paul Flicek, John A. Foekens, Kwun M. Fong, Christopher S. Foster, Natalie S. Fox, Michael Fraser, Scott Frazer, Milana Frenkel‐Morgenstern, William A. Friedman, Catrina C. Fronick, Akihiro Fujimoto, Masashi Fujita, Masashi Fukayama, Lucinda A. Fulton, Robert S. Fulton, Mayuko Furuta, P. Andrew Futreal, Anja Füllgrabe, Stacey Gabriel, Jianjiong Gao, Shengjie Gao, Levi A. Garraway, Øystein Garred, Erik Garrison, Nils Gehlenborg, Josep L. L. Gelpi, Joshy George, Daniela S. Gerhard, Clarissa Gerhäuser, Moritz Gerstung, Mohammed Ghori, Ronald Ghossein, Nasra H. Giama, Richard A. Gibbs, Bob Gibson, Anthony J. Gill, Pelvender Gill, Dilip D. Giri, Dominik Głodzik, Vincent J. Gnanapragasam, Maria Elisabeth Goebler, Mary J. Goldman, Carmen Gómez, Santiago Gonzalez, Abel González-Pérez, Dmitry A. Gordenin, James Gossage, Kunihito Gotoh, Ramaswamy Govindan, Dorthe Grabau, Janet S. Graham, Robert C. Grant, Anthony R. Green, Eric Green, Liliana Greger, Nicola Grehan, Sonia Grimaldi, Sean M. Grimmond, Robert L. Grossman, Adam Grundhoff, Gunes Gundem, Manaswi Gupta, Shailja Gupta, Jonathan Göke, Gavin Ha, Andrea Haake, Siegfried Haas, Kerstin Haase, James E. Haber, Faraz Hach, Syed Haider, Natsuko Hama, Freddie C. Hamdy, Anne Hamilton, Leng Han, George B. Hanna, Martin Hansmann, Olivier Harismendy, Ivon Harliwong, Eoghan Harrington, Takanori Hasegawa, David Haussler, Steve Hawkins, Shinya Hayami, Shuto Hayashi, D. Neil Hayes, Stephen J. Hayes, Nicholas K. Hayward, Steven Hazell, Yao He, Allison P. Heath, Simon Heath, David W. Hedley, Apurva M. Hegde, David I. Heiman, Michael C. Heinold, Zachary Heins, Lawrence E. Heisler, Eva Hellström‐Lindberg, Seong Gu Heo, Austin J. Hepperla, José María Heredia‐Genestar, Peter Hersey, Hólmfríður Hilmarsdóttir, Jonathan Hinton, Satoshi Hirano, Nobuyoshi Hiraoka, Katherine A. Hoadley, Jessica I. Hoell, Steve Hoffmann, Oliver Hofmann, Andrea Holbrook, Aliaksei Z. Holik, Michael A. Hollingsworth, Oliver Holmes, Robert A. Holt, Hong Chen, Eun Pyo Hong, Jongwhi H. Hong, Gerrit K. Hooijer, Fumie Hosoda, Yong Hou, Volker Hovestadt, William Howat, Alan P. Hoyle, Ralph H. Hruban, Taobo Hu, Xing Hua, Kuan-lin Huang, Mei Huang, Mi Ni Huang, Vincent Huang, Yi Huang, Wolfgang Huber, Thomas J. Hudson, Michael Hummel, Jillian A. Hung, David G. Huntsman, Ted R. Hupp, Jason T. Huse, Matthew R. Huska, Barbara Hutter, Carolyn M. Hutter, Daniel Hübschmann, Christine A. Iacobuzio–Donahue, Charles D. Imbusch, Marcin Imieliński, Seiya Imoto, William B. Isaacs, Shumpei Ishikawa, Murat Iskar, S. M. Ashiqul Islam, Michael Ittmann, Sinisa Ivkovic, Jocelyne Jacquemier, Valerie Jakrot, Nigel B. Jamieson, Gun Ho Jang, Se Jin Jang, Joy C. Jayaseelan, Reyka G. Jayasinghe, Karine Jegalian, Jennifer L. Jennings, Seung-Hyup Jeon, Lara Jerman, Yuan Ji, Wei Jiao, Peter A. Johansson, Amber L. Johns, Jeremy Johns, Clemency Jolly, Yann Joly, Jón G. Jónasson, Corbin D. Jones, David Jones, Nic Jones, Steven J.M. Jones, Jos Jonkers, Young Seok Ju, Hartmut Juhl, Jongsun Jung, Natalie Jäger, Rolf Kabbe, Vera B. Kaiser, Hojabr Kakavand, Sangeetha Kalimuthu, Christof von Kalle, Koo Jeong Kang, Katalin Karászi, Beth Y. Karlan, Rosa Karlić, Dennis Karsch, Karin S. Kassahn, Hitoshi Katai, Mamoru Kato, Hiroto Katoh, Yoshiiku Kawakami, Jonathan D. Kay, Stephen H. Kazakoff, Marat D. Kazanov, Maria Keays, Electron Kebebew, Richard Kefford, James G. Kench, Catherine J. Kennedy, Jules N. A. Kerssemakers, David Khoo, Vincent Khoo, Narong Khuntikeo, Helena Kilpinen, Hark Kyun Kim, Hyung‐Lae Kim, Hyung-Yong Kim, Hyunghwan Kim, Tari A. King, Kortine Kleinheinz, Leszek J. Klimczak, Stian Knappskog, Michael Kneba, Bartha Maria Knoppers, Youngil Koh, Daisuke Komura, Mitsuhiro Komura, Gu Kong, Marcel Kool, Viktoriya Korchina, Andrey Korshunov, Michael Koscher, Roelof Koster, Zsofia Kote‐Jarai, Antonios Koures, Milena Kovačević, Bárbara Kremeyer, Helene Kretzmer, Markus Kreuz, Savitri Krishnamurthy, Dieter Kube, Kiran Kumar, Pardeep Kumar, Yogesh Kumar, Ritika Kundra, Kirsten Kübler, Ralf Küppers, Jesper Lagergren, Phillip H. Lai, Peter W. Laird, Sunil R. Lakhani, Christopher M. Lalansingh, Emilie Lalonde, Fabien C. Lamaze, Adam Lambert, Eric S. Lander, Pablo Landgraf, Luca Landoni, Anita Langerød, Denis Larsimont, Mark Lathrop, Loretta M. S. Lau, Chris Lawerenz, Rita T. Lawlor, Alexander J. Lazar, Ana Mijalkovic Lazic, Xuan Le, Darlene Lee, Eunjung Alice Lee, Hee Jin Lee, Jake June-Koo Lee, Jeong‐Yeon Lee, Juhee Lee, Ming Ta Michael Lee, Henry Lee-Six, Hans Lehrach, Dido Lenze, Conrad Leonard, Daniel Leongamornlert, Ignaty Leshchiner, Louis Létourneau, Ivica Letunić, Douglas A. Levine, Lora Lewis, Tim Ley, Constance H. Li, Haiyan Irene Li, Jun Li, Lin Li, Siliang Li, Xiaobo Li, Xinyue Li, Yilong Li, Han Liang, Sheng‐Ben Liang, Peter Lichter, Pei Lin, W. Marston Linehan, Ole Christian Lingjærde, Dongbing Liu, Fei-Fei Fei Liu, Fenglin Liu, Jia Liu, Xingmin Liu, Julie Livingstone, Dimitri Livitz, Naomi Livni, Markus Loeffler, Georgina V. Long, Armando López‐Guillermo, David N. Louis, Laurence Lovat, Yiling Lu, Yong‐Jie Lu, Youyong Lu, Claudio Luchini, Ilinca M. Lungu, Xuemei Luo, Hayley J. Luxton, Andy G. Lynch, Lisa Lype, Cristina López, Carlos López-Otı́n, Z. Eric, Yussanne Ma, Gaëtan MacGrogan, Shona MacRae, Geoff Macintyre, Kazuhiro Maejima, Andrea Mafficini, Dennis T. Maglinte, Arindam Maitra, Partha P. Majumder, Luca Malcovati, Salem Malikić, Giuseppe Malleo, Graham J. Mann, Luisa Mantovani‐Löffler, Giovanni Marchegiani, Elaine R. Mardis, Adam A. Margolin, Maximillian G. Marin, Florian Markowetz, Julia Markowski, Jeffrey S. Marks, Tomàs Marquès‐Bonet, Marco A. Marra, Luke Marsden, John W.M. Martens, Sancha Martin, José I. Martín‐Subero, R. Jay Mashl, Charlie E. Massie, Thomas J. Matthew, Lucy Matthews, Erik Mayer, Simon Mayes, Michael Mayo, Faridah Mbabaali, Karen McCune, Ultan McDermott, Michael D. McLellan, John D. McPherson, John R. McPherson, Treasa A. McPherson, Samuel R. Meier, Alice Meng, Shaowu Meng, Andrew Menzies, Neil D. Merrett, Sue Merson, Matthew Meyerson, Piotr A. Mieczkowski, George L. Mihaiescu, Sanja Mijalković, Tom Mikkelsen, Michele Stanislaw Milella, Linda Mileshkin, Christopher A. Miller, David K. Miller, Jessica K. Miller, Gordon B. Mills, Ana Milovanovic, Sarah Minner, Marco Miotto, Gisela Mir Arnau, Thomas J. Mitchell, Satoru Miyano, Naoki Miyoshi, Shinichi Mizuno, Fruzsina Molnár‐Gábor, Malcolm J. Moore, Richard A. Moore, Sandro Morganella, Quaid Morris, Lisle E. Mose, Catherine D. Moser, Andrew J. Mungall, Karen Mungall, Elizabeth A. Musgrove, Ville Mustonen, David G. Mutch, Francesc Muyas, Donna M. Muzny, Alfonso Muñoz, Jerome K. Myers, Ola Myklebost, Peter Möller, Genta Nagae, Adnan Nagrial, Hardeep K. Nahal-Bose, Hitoshi Nakagama, Hiromi Nakamura, Toru Nakamura, Kaoru Nakano, Tannistha Nandi, Jyoti Nangalia, Mia Nastic, Arcadi Navarro, Fábio C. P. Navarro, David E. Neal, Gerd Nettekoven, Felicity Newell, Steven Newhouse, Yulia Newton, Alvin Wei Tian Ng, Chi‐Fai Ng, Jonathan Nicholson, David M. Nicol, Yongzhan Nie, G. Petur Nielsen, Serena Nik-Zainal, Michael S. Noble, Kátia Nones, Paul A. Northcott, Faiyaz Notta, Brian D. O’Connor, Peter O’Donnell, Maria O’Donovan, Sarah O’Meara, Brian Patrick O’Neill, J. Robert O’Neill, David Ocaña, Angelica Ochoa, Layla Oesper, Christopher Ogden, Hideki Ohdan, Kazuhiro Ohi, Lucila Ohno‐Machado, Karin A. Oien, Akinyemi I. Ojesina, Hidenori Ojima, Takuji Okusaka, Larsson Omberg, Choon Kiat Ong, Stephan Ossowski, German Ott, B. F. Francis Ouellette, Christine P’ng, Salvatore Paiella, Chawalit Pairojkul, Marina Pajic, Qiang Pan‐Hammarström, Elli Papaemmanuil, Irene Papatheodorou, Nagarajan Paramasivam, Ji Wan Park, Joong‐Won Park, Peter J. Park, Simon L. Parsons, Harvey I. Pass, Danielle Pasternack, Alessandro Pastore, Ann‐Marie Patch, Iris Pauporté, Antonio Pea, John V. Pearson, Chandra Sekhar Pedamallu, Paolo Pederzoli, Martin Peifer, Nathan A. Pennell, Charles M. Perou, Marc D. Perry, Gloria M. Petersen, Myron Peto, Nicholas J. Petrelli, Robert Petryszak, Stefan M. Pfister, Mark Phillips, Oriol Pich, Hilda A. Pickett, Todd Pihl, Nischalan Pillay, Sarah E. Pinder, Mark Pinese, Andreia V. Pinho, Esa Pitkänen, Xavier Pivot, Elena Piñeiro-Yáñez, Laura Planko, Christoph Plass, Paz Polak, Irinel Popescu, Olga Potapova, Aparna Prasad, Shaun R. Preston, Manuel Prinz, Antonia L. Pritchard, Stephenie D. Prokopec, Elena Provenzano, Xosé S. Puente, Montserrat Puiggròs, Gulietta M. Pupo, Colin A. Purdie, Michael C. Quinn, Raquel Rabionet, Janet S. Rader, Bernhard Radlwimmer, Petar Radovic, Benjamin Raeder, Keiran Raine, Manasa Ramakrishna, Kamna Ramakrishnan, Suresh Ramalingam, W. Kimryn Rathmell, Tobias Rausch, Guido Reifenberger, Jorge S. Reis‐Filho, Victor E. Reuter, Sheila M. Reynolds, Yasser Riazalhosseini, Andrea L. Richardson, Julia Richter, Matthew D. Ringel, Markus Ringnér, Yasushi Rino, Karsten Rippe, Jeffrey Roach, Lewis R. Roberts, Nicola D. Roberts, Steven A. Roberts, A. Gordon Robertson, Alan J. Robertson, Javier Bartolomé Rodriguez, Bernardo Rodríguez–Martín, F. Germán Rodríguez-González, Michael H. A. Roehrl, Marius Rohde, Hirofumi Rokutan, Gilles Romieu, Ilse Rooman, Tom Roques, Daniel Rosebrock, Mara Rosenberg, Philip Rosenstiel, Andreas Rosenwald, Edward Rowe, Romina Royo, Steven G. Rozen, Yulia Rubanova, Vasilisa A. Rudneva, Borislav C. Rusev, Andrea Ruzzenente, Gunnar Rätsch, Radhakrishnan Sabarinathan, Veronica Y. Sabelnykova, Sara Sadeghi, Natalie Saini, Mihoko Saito-Adachi, Adriana Salcedo, Roberto Salgado, Richard Sallari, Charles Saller, Roberto Salvia, Michelle Sam, Jaswinder S. Samra, Francisco Sánchez-Vega, Grant Sanders, Rajiv Sarin, Iman Sarrafi, Aya Sasaki-Oku, Torill Sauer, Guido Sauter, Robyn P.M. Saw, Maria Scardoni, Christopher J. Scarlett, Aldo Scarpa, Ghislaine Scélo, Dirk Schadendorf, Jacqueline E. Schein, Markus B. Schilhabel, Matthias Schlesner, Thorsten Schlomm, Heather K. Schmidt, Sarah‐Jane Schramm, Stefan Schreiber, Nikolaus Schultz, Roland F. Schwarz, Richard A. Scolyer, David W. Scott, Ralph Scully, Raja S. Seethala, Ayellet V. Segrè, Iris Selander, Colin A. Semple, Yasin Şenbabaoğlu, Subhajit Sengupta, Elisabetta Sereni, Stefano Serra, Dennis C. Sgroi, Nimish Shah, Sagedeh Shahabi, Catherine A. Shang, Ping Shang, Troy Shelton, Hui Shen, Rebecca Shepherd, Ruian Shi, Yan Shi, Yu-Jia Shiah, Tatsuhiro Shibata, Juliann Shih, Eigo Shimizu, Kiyo Shimizu, Seung Jun Shin, Yuichi Shiraishi, Tal Shmaya, Ilya Shmulevich, Solomon I. Shorser, Charles Short, Suyash Shringarpure, Craig D. Shriver, Reiner Siebert, Anieta M. Sieuwerts, Sabina Signoretti, Katarzyna Sikora, Michele Simbolo, Ronald Simon, Janae V. Simons, Jared T. Simpson, Peter T. Simpson, Samuel Singer, Payal Sipahimalani, Tara Skelly, Marcel Smid, Jaclyn Smith, Karen Smith‐McCune, Nicholas D. Socci, Heidi J. Sofia, Matthew G. Soloway, Lei Song, Anil K. Sood, Sharmila Sothi, Christos Sotiriou, Cameron M. Soulette, Paul N. Span, Paul T. Spellman, Nicola Sperandio, Andrew J. Spillane, Oliver Spiro, Jonathan Spring, Johan Staaf, Peter F. Stadler, Peter Staib, Stefan G. Stark, Lucy Stebbings, Ólafur Andri Stefánsson, Oliver Stegle, Lincoln D. Stein, Alasdair Stenhouse, Chip Stewart, Stephan Stilgenbauer, Miranda D. Stobbe, Michael R. Stratton, Jonathan R. Stretch, Adam J. Struck, Henk G. Stunnenberg, Hong Su, Xiaoping Su, Ren Sun, Stéphanie Sungalee, Hana Sušak, Akihiro Suzuki, Fred C.G.J. Sweep, Monika Szczepanowski, Holger Sültmann, Takashi Yugawa, Angela Tam, Benita Kiat Tee Tan, Donghui Tan, Patrick Tan, Hiroko Tanaka, Hirokazu Taniguchi, Tomas Tanskanen, Maxime Tarabichi, Roy Tarnuzzer, Patrick Tarpey, Morgan L. Taschuk, Kenji Tatsuno, Simon Tavaré, Darrin F. Taylor, Amaro Taylor‐Weiner, Jon W. Teague, Bin Tean Teh, Varsha Tembe, Javier Temes, Kevin Thai, Sarah P. Thayer, Nina Thiessen, Gilles Thomas, Sarah Thomas, Alan Thompson, Alastair M. Thompson, John F. Thompson, R. Houston Thompson, Heather Thorne, Leigh B. Thorne, Adrian Thorogood, Nebojša Tijanić, Lee E. Timms, Roberto Tirabosco, Marta Tojo, Stefania Tommasi, Christopher W. Toon, Umut H. Toprak, David Torrents, Giampaolo Tortora, Jörg Tost, Yasushi Totoki, David Townend, Nadia Traficante, Isabelle Treilleux, Jean-Rémi Trotta, Lorenz Trümper, Ming‐Sound Tsao, José M. C. Tubío, Olga Tucker, Richard Turkington, Daniel J. Turner, Andrew Tutt, Masaki Ueno, Naoto T. Ueno, Christopher B. Umbricht, Tim Underwood, Lara Urban, Tomoko Urushidate, Tetsuo Ushiku, David Van Den Berg, Steven Van Laere, Peter Van Loo, Erwin G. Van Meir, Gert G. Van den Eynden, Theodorus van der Kwast, Naveen Vasudev, Ravikiran Vedururu, Umadevi Veluvolu, Shankar Vembu, Peter Vermeulen, Clare Verrill, Alain Viari, David Vicente, Caterina Vicentini, K. VijayRaghavan, Juris Vīksna, Ricardo E. Vilain, Izar Villasante, Anne Vincent‐Salomon, Tapio Visakorpi, Douglas Voet, Paresh Vyas, Ignacio Vázquez-Garćıa, Nick M. Waddell, Nicola Waddell, Rabea Wagener, Jeremiah A. Wala, Jian Wang, Linghua Wang, Qi Wang, Wenyi Wang, Yumeng Wang, Zhining Wang, Paul Waring, Hans-Jörg Warnatz, Anne Y. Warren, David C. Wedge, Dieter Weichenhan, Paul Weinberger, John N. Weinstein, Daniel J. Weisenberger, Ian Welch, Michael C. Wendl, Johannes Werner, Justin P. Whalley, Hayley C. Whitaker, Dennis A. Wigle, Matthew D. Wilkerson, Ashley Williams, James S. Wilmott, Gavin W. Wilson, Julie M. Wilson, Richard K. Wilson, Boris Winterhoff, Jeffrey A. Wintersinger, Maciej Wiznerowicz, Stephan Wolf, Bernice H. Wong, Tina Wong, Winghing Wong, Youngchoon Woo, Scott Wood, Bradly G. Wouters, A. Jordan Wright, Derek Wright, Mark H. Wright, Chin‐Lee Wu, Dai‐Ying Wu, Jianmin Wu, Kui Wu, Yang Wu, Zhenggang Wu, Liu Xi, Tian Xia, Qian Xiang, Xiao Xiao, Rui Xing, Heng Xiong, Qinying Xu, Yanxun Xu, Hong Xue, Shinichi Yachida, Sergei Yakneen, Takafumi N. Yamaguchi, Masakazu Yamamoto, Shogo Yamamoto, Hiroki Yamaue, Fan Yang, Huanming Yang, Jean Yang, Liming Yang, Lixing Yang, Shanlin Yang, Tsun-Po Yang, Yang Yang, Xiaotong Yao, Marie‐Laure Yaspo, Lucy Yates, Christina Yau, Chen Ye, Kai Ye, Venkata D. Yellapantula, Christopher J. Yoon, Sung-Soo Yoon, Fouad Yousif, Kaixian Yu, Willie Yu, Yingyan Yu, Ke Yuan, Yuan Yuan, Denis Yuen, Christina K. Yung, Olga Zaikova, Jorge Zamora, Marc Zapatka, Jean C. Zenklusen, Thorsten Zenz, Nikolajs Zeps, Cheng‐Zhong Zhang, Fan Zhang, Hailei Zhang, Hongwei Zhang, Hongxin Zhang, Jiashan Zhang, Junjun Zhang, Xiuqing Zhang, Zemin Zhang, Liangtao Zheng, Xiuqing Zheng, Wanding Zhou, Yong Zhou, Bin Zhu, Hongtu Zhu, Jingchun Zhu, Shida Zhu, Xueqing Zou, Anna DeFazio, Nicholas van As, Carolien H. M. van Deurzen, Marc J. van de Vijver, L. van’t Veer
66Citations signalées — pas une note de qualité
473Institutions déclarées
36Pays d’affiliation déclarés
Résumé fourni par la source
The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutations in coding and non-coding sites within cancer whole genomes. Using a total of 1373 genomic features derived from public sources, DriverPower's background mutation model explains up to 93% of the regional variance in the mutation rate across multiple tumour types. By incorporating functional impact scores, we are able to further increase the accuracy of driver discovery. Testing across a collection of 2583 cancer genomes from the PCAWG project, DriverPower identifies 217 coding and 95 non-coding driver candidates. Comparing to six published methods used by the PCAWG Drivers and Functional Interpretation Working Group, DriverPower has the highest F1 score for both coding and non-coding driver discovery. This demonstrates that DriverPower is an effective framework for computational driver discovery.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Combined burden and functional impact tests for cancer driver discovery using DriverPower
- Date Crossref
- 05/02/2020
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Ontario Institute for Cancer ResearchUniversity of TorontoWellcome Sanger InstituteThe University of Texas MD Anderson Cancer CenterBaylor College of MedicineQuantitative BioSciencesJackson LaboratoryThe Jackson Laboratory for Genomic MedicineBroad InstituteHarvard UniversityDana-Farber/Boston Children's Cancer and Blood Disorders CenterAarhus UniversityAarhus University HospitalRIKEN Center for Integrative Medical SciencesUniversity of BernUniversity of CopenhagenUniversity Hospital of BernNovo Nordisk FoundationTechnical University of DenmarkUniversity of CambridgeCambridge University Hospitals NHS Foundation TrustIcahn School of Medicine at Mount SinaiGerman Cancer Research CenterHeidelberg UniversityKorea Advanced Institute of Science and TechnologyInstitute for Research in BiomedicineCornell UniversityWeill Cornell MedicineUppsala UniversityUniversitat Pompeu FabraScience for Life LaboratoryThe University of QueenslandBarcelona Supercomputing CenterUniversitat Politècnica de CatalunyaUniversidade do PortoEuropean Bioinformatics InstituteUniversity of Milano-BicoccaThe University of MelbournePeter MacCallum Cancer CentreYale UniversityCentre for Genomic RegulationUniversity of California, Santa CruzStanford UniversityMassachusetts General HospitalThe University of Texas Health Science Center at HoustonSimon Fraser UniversityCenter for Cancer ResearchMemorial Sloan Kettering Cancer CenterETH ZurichUniversity Hospital ZurichSIB Swiss Institute of BioinformaticsMassachusetts Institute of TechnologyNational Cancer CenterSamsung (South Korea)Samsung Medical CenterUniversity of California San DiegoSungkyunkwan UniversityEuropean Molecular Biology LaboratoryInstitute of Computer SciencePolish Academy of SciencesUniversity of GothenburgCanada's Michael Smith Genome Sciences CentreBGI Group (China)China National GeneBankHarvard University PressGhent UniversitySangmyung UniversitySpanish National Cancer Research CentrePrinceton UniversityVall d'Hebron Institut de RecercaDana-Farber Cancer InstituteTokyo Medical and Dental UniversityTokyo University of ScienceJapan Science and Technology AgencyThe University of TokyoTallinn University of TechnologySickKids FoundationKarolinska InstitutetInstitució Catalana de Recerca i Estudis AvançatsNorwegian University of Science and TechnologyXi'an Jiaotong UniversityCharité - Universitätsmedizin BerlinOregon Health & Science UniversityChinese University of Hong KongNational Institutes of HealthNational Cancer InstituteUniversity of HoustonNorthwestern UniversityUniversity of ZurichMount Sinai HospitalLunenfeld-Tanenbaum Research InstituteToronto General HospitalUniversity of HelsinkiUniversity of ChicagoKeimyung University Dongsan Medical CenterKeimyung UniversityGachon University Gil Medical CenterHiroshima UniversityKing Faisal Specialist Hospital & Research CentreUniversität HamburgUniversity Medical Center Hamburg-EppendorfLeibniz Institute of Virology (LIV)UC San Diego Health SystemMoores Cancer CenterUniversidade de Santiago de CompostelaCenter for Research in Molecular Medicine and Chronic DiseasesUniversidade de VigoRoyal National Orthopaedic HospitalUniversity College LondonUniversität UlmChristian-Albrechts-Universität zu KielSalford Royal NHS Foundation TrustJames S. McDonnell FoundationTokyo Women's Medical UniversityMolecular Oncology (United States)Los Alamos National LaboratoryUniversity Health NetworkNottingham University Hospitals NHS TrustEpigenomics (Germany)University of North Carolina at Chapel HillVector InstituteOslo University HospitalConsorci Institut D'Investigacions Biomediques August Pi I SunyerUniversitat de BarcelonaUniversity of GlasgowWashington University in St. LouisAlvin J. Siteman Cancer CenterUniversity of LeedsSt James's University HospitalPrincess Alexandra HospitalUniversity Hospitals of ClevelandCase Western Reserve UniversityGloucestershire Royal HospitalUniversity of CalgaryInstitute of Cancer ResearchJohns Hopkins UniversitySidney Kimmel Comprehensive Cancer CenterRoyal Stoke University HospitalUniversity Hospital Southampton NHS Foundation TrustHuman Longevity (United States)La Trobe UniversityOlivia Newton-John Cancer Wellness & Research CentreOlivia Newton-John Cancer Research InstituteChinese Academy of SciencesComputer Network Information CenterGenome CanadaBuck Institute for Research on AgingDuke Medical CenterMedizinische Hochschule HannoverCedars-Sinai Medical CenterQueen Mary University of LondonHebrew University of JerusalemLeipzig UniversityUniversity of Southern CaliforniaSecretaria de SaludBerlin Institute of Health at Charité - Universitätsmedizin BerlinGarvan Institute of Medical ResearchGlasgow Royal InfirmaryUNSW SydneyDuke University HospitalSouth Western Sydney Local Health DistrictNational Institute of Biomedical GenomicsUniversity of OsloInstitute of Cancer ResearchDuke-NUS Medical SchoolLund UniversityHeinrich Heine University DüsseldorfFriedrich-Ebert-KrankenhausUniversity of OxfordMcGill UniversityTampere University HospitalTampere UniversityUniversity of California, Los AngelesLeeds Teaching Hospitals NHS TrustCentre Léon BérardFox Chase Cancer CenterCentre international de recherche sur le cancerUniversity of East AngliaEarlham InstituteRadboud University NijmegenRadboud University Medical CenterRadboud Institute for Molecular Life SciencesBrigham and Women's HospitalPrincess Margaret Cancer CentreUniversity of ManchesterCancer Research UK Manchester InstituteJohns Hopkins MedicineThe Netherlands Cancer InstituteOncode InstituteNational Center for Tumor DiseasesBundesministerium für Forschung, Technologie und RaumfahrtThe University of SydneyMelanoma Institute AustraliaUniversity Hospital MünsterFoundation Medicine (United States)University of California, San FranciscoRoyal Marsden NHS Foundation TrustInstitut Gustave RoussyCancer Research UK Cambridge CenterUniversity of MichiganMichigan Center for Translational PathologyUniversity of PaviaUniversity of Alabama at BirminghamUniversity of TasmaniaUniversity of OttawaMayo Clinic in ArizonaWollongong HospitalInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'EnvironnementMayo ClinicWinnMedWestmead HospitalWestmead Institute for Medical ResearchElectronics and Telecommunications Research InstituteInstitut National du CancerNational Cancer Centre SingaporeUniversity Hospital Schleswig-HolsteinUniversity of LübeckUniversity of AucklandRoyal Children's HospitalWalter and Eliza Hall Institute of Medical ResearchMurdoch Children's Research InstituteVictorian Institute of Forensic MedicineNorfolk and Norwich University HospitalUniversity of CologneCenter for Systems BiologyInternational Genomics ConsortiumChildren's Hospital at WestmeadBarking, Havering And Redbridge University Hospitals NHS TrustUniversity of VeronaPediatrics and GeneticsMRC Cancer UnitSeven Bridges Genomics (United States)Addenbrooke's HospitalUniversity of PaduaCa' Foncello HospitalUniversity of GenevaUniversity of LausanneThe Francis Crick InstituteGenome Institute of SingaporeKU LeuvenUniversity of TübingenNational University of SingaporeInstitut Jules BordetShadyside HospitalWellesley CollegeHefei University of TechnologyUniversity of AntwerpGZA Ziekenhuizen Campus Sint-AugustinusUniversity of PennsylvaniaUniversitat de Vic - Universitat Central de CatalunyaWellcome TrustQIMR Berghofer Medical Research InstituteHospital for Sick ChildrenQueen Elizabeth University HospitalProstate Cancer CanadaMedicon VillageGroupe de Recherche en Droit, Économie, GestionCentro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaIcelandic Cancer SocietyXijing HospitalAir Force Medical UniversityRigshospitaletAustralian Institute of Tropical Health and MedicineUniversité de MontréalJames Cook UniversityFondazione IRCCS Istituto Neurologico Carlo BestaBioplatforms AustraliaLondon CancerCancer Genomics CentrePrince Charles HospitalUniversity of LiverpoolBar-Ilan UniversityUniversity of FloridaUniversity of WürzburgCambridge SchoolUniversity of MiamiSylvester Comprehensive Cancer CenterNational Institute of Environmental Health SciencesSt Thomas' HospitalHospital del Mar Research InstituteOsaka International Cancer InstituteSkåne University HospitalBeatson West of Scotland Cancer CentreNational Human Genome Research InstituteVictorian Comprehensive Cancer CentreGerman Center for Infection ResearchGovernment of IndiaDepartment of BiotechnologyMinistry of Science and TechnologyBrandeis UniversityUniversity of British ColumbiaImperial College LondonGoethe University FrankfurtUniversity of San DiegoHoward Hughes Medical InstituteWakayama Medical UniversityUniversity of Tennessee Health Science CenterWest Cancer CenterPeking UniversityCenter for Life SciencesChildren's Hospital of PhiladelphiaHallym UniversityInstitut de Biologia EvolutivaUniversity Hospital HeidelbergHokkaido UniversityTokyo National HospitalLeibniz Institute on Aging - Fritz Lipmann Institute (FLI)University of Nebraska Medical CenterSyneos Health (South Korea)Amsterdam UMC Location University of AmsterdamHong Kong University of Science and TechnologyShenzhen Bioeasy Biotechnology (China)AbbVie (United States)BC Cancer AgencyEdinburgh Royal InfirmaryMax Delbrück CenterHeidelberg Institute for Stem Cell Technology and Experimental MedicineNew York Genome CenterMichael E. DeBakey VA Medical CenterHanyang UniversityAsan Medical CenterEndeavor HealthChicago Department of Public HealthUniversity of LjubljanaMcGill University and Génome Québec Innovation CentreHopp Children's Cancer Center HeidelbergCancer Research HorizonsInstitute of Genetics and CancerUniversity of EdinburghUniversity of ZagrebSouth Australia PathologyNational Cancer Centre JapanSkolkovo Institute of Science and TechnologyInstitute for Information Transmission ProblemsDmitry Rogachev National Research Center of Pediatric Hematology, Oncology and ImmunologyGeorge Washington UniversityMacquarie UniversityRoyal Prince Alfred HospitalKhon Kaen UniversityEwha Womans UniversityDana-Farber Brigham Cancer CenterUniversity of BergenSeoul National University HospitalUniversity of GöttingenUniversity of Duisburg-EssenVan Andel InstituteKing's College LondonGuy's and St Thomas' NHS Foundation TrustRoyal Brisbane and Women's HospitalChildren's Medical Research InstituteBoston Children's HospitalInstitute of Biomedical Sciences, Academia SinicaMax Planck Institute for Molecular GeneticsBiobyte Solutions (Germany)Gynecologic Oncology GroupNew York UniversityLeidos (United States)Leidos Biomedical Research Inc. (United States)Second Military Medical UniversityPeking University Cancer HospitalBeijing HospitalInstitute for Systems BiologyUniversity of St AndrewsUniversidad de OviedoInstitut BergoniéChildren's Hospital of Los AngelesOrthopädische PraxisNationwide Children's HospitalDuke UniversityUniversitat Autònoma de BarcelonaInstitut Català de Paleontologia Miquel CrusafontOxford Nanopore Technologies (United Kingdom)University of California, DavisWestern Sydney UniversityHenry Ford HospitalKyushu UniversityHeidelberg Academy of Sciences and HumanitiesRoswell Park Comprehensive Cancer CenterPenrose-St. Francis Health ServicesUniversity Hospital UlmGerman Cancer AidSt. Jude Children's Research HospitalCarleton CollegeHudsonAlpha Institute for BiotechnologyKeio UniversitySage BionetworksRobert Bosch HospitalNYU Langone HealthCleveland ClinicMayo Clinic in FloridaChristiana Care Health SystemSRA International (United States)Guy's HospitalKings Health PartnersInsermCentre Hospitalier Universitaire de BesançonInstitutul Clinic FundeniRoyal Surrey County HospitalNIHR Cambridge Biomedical Research CentreNinewells HospitalMedical College of WisconsinEmory UniversityVanderbilt UniversityThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteYokohama City UniversityWashington State UniversityUniversitätsklinikum Gießen und MarburgInstitut de Recherche en Cancérologie de MontpellierNorth Bristol NHS TrustNewYork–Presbyterian HospitalSingHealthNew York Hospital QueensPresbyterian HospitalNational Heart Centre SingaporeTata Institute of Fundamental ResearchNational Centre for Biological SciencesAnalytical Biological Services (United States)Tata Memorial HospitalAdvanced Centre for Treatment, Research and Education in CancerHunter WaterEssen University HospitalMartini-KlinikGerman Cancer SocietyDeutsches Konsortium für Translationale KrebsforschungBeth Israel Deaconess Medical CenterCancer Research InstituteUniversity of PittsburghMassachusetts Eye and Ear InfirmaryJapan Agency for Medical Research and DevelopmentKorea UniversityWalter Reed National Military Medical CenterUniversity Hospitals Coventry and Warwickshire NHS TrustSankt-Antonius-Hospital EschweilerUniversity of IcelandInstitut CurieSingapore General HospitalNational University Cancer Institute, SingaporeColumbia University Irving Medical CenterInstitute of Molecular and Cell BiologyIstituto Tumori BariAgostino Gemelli University PolyclinicIstituti di Ricovero e Cura a Carattere ScientificoCommissariat à l'Énergie Atomique et aux Énergies AlternativesGenoscopeMaastricht UniversityLyon 1 UniversitéUniversity Hospitals Birmingham NHS Foundation TrustQueen's University BelfastUniversity of SouthamptonWinship Cancer InstituteRED Consulting (Norway)John Radcliffe HospitalUniversity of LatviaColumbia UniversityOxford BioMedica (United Kingdom)Augusta UniversityGeorgia Regents Medical CenterWythenshawe HospitalLeibniz Institute for Baltic Sea Research WarnemündeCentre for Human GeneticsPoznan University of Medical SciencesInternational Institute for Molecular OncologyMRC University of Glasgow Centre for Virus ResearchHuazhong University of Science and TechnologyThe University of OsakaTri-Institutional PhD Program in Chemical BiologyFirst Affiliated Hospital of Xi'an Jiaotong UniversityRuijin HospitalEpworth HospitalEastern HealthMonash UniversityThe Ohio State UniversityErasmus MC Une affiliation ne permet pas de déduire la nationalité d’un auteur.
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