Accès ouvert déclaré
2019
article
Multimorbidity in Elderly Persons According to the Year of Diagnosis of Human Immunodeficiency Virus Infection: A Cross-sectional Dat’AIDS Cohort Study
Marie Demontès, Sabrina Eymard Duvernay, Clotilde Allavena, T Jovelin, Jacques Reynes, Maxime Hentzien, Isabelle Ravaux, Pierre Delobel, Sylvie Brégigeon, David Rey, Tristan Ferry, Amandine Gagneux‐Brunon, O Robineau, Pascal Puglièse, Claudine Duvivier, André Cabie, Catherine Chirouze, Christine Jacomet, I. Lamaury, Dominique Merrien, Bruno Hoën, Laurent Hocqueloux, Antoine Chéret, Christine Katlama, C. Arvieux, Pierre Krolak‐Salmon, Alain Makinson, C. Drobacheff-Thiébaut, A Foltzer, Kévin Bouiller, Laurence Mathieu, C Chirouze, Quentin Lepiller, F Bozon, O Babre, Serge Brunel, Patrice Muret, H. Laurichesse, O. Lesens, M. Vidal, Natacha Mrozek, C. Auméran, Olivier Baud, V. Corbin, P. Letertre-Gibert, S. Casanova, J. Prouteau, Isabelle Fabre, E Curlier, Rachida Ouissa, C Herrmann-Storck, B Tressieres, T. Bonijoly, C M Receveur, F Boulard, Cortés-González José Daniel, C Clavel, Philippe Van de Perre, Thomas Guimard, O Bollangier, S Léautez, Marine Morrier, L Laine, Florence Ader, A Becker, F. Biron, A. Boibieux, L Cotte, P Miailhes, T Perpoint, S Roux, Claire Triffault-Fillit, S Degroodt, Céline Brochier‐Armanet, F Valour, Christian Chidiac, A Ménard, Y. A. Belkhir, Philippe Colson, C Dhiver, A Madrid, M Martin-Degiovani, Line Meddeb, Malika Mokhtarı, A Motte, A Raoux, C Tamalet, C Toméi, H Tissot Dupont, O Zaegel-Faucher, V Obry-Roguet, H Laroche, M Orticoni, J M Soavi, P Geneau de Lamarlière, E. Ressiot, J M Ducassou, I Jaquet, S Galie, Anne Galinier, P. Martinet, M. P. J. Landon, S A Ritleng, A Ivanova, C. Debreux, C. Lions, Sylvie Abel, Ornella Cabras, Lise Cuzin, K Guitteaud, Marina Illiaquer, S. Pierre-François, Lindsay Osei, J Pasquier, K Rome, E Sidani, Marc‐Olivier Turmel, C. Varache, N Atoui, M Bistoquet, Éric Delaporte, Vincent Le Moing, A Makinson, N Meftah, Corinne Merle De Boever, B Montes, Ana Ferrer, E Tuaillon, J Reynes, Marie André, L. Boyer, Pierrette Bouillon, M Delestan, C Rabaud, T. May, C Bernaud, E Billaud, Charlotte Biron, B. Bonnet, Sabelline Bouchez, David Boutoille, C Brunet-Cartier, C Deschanvres, Nancy Hall, T Jovelin, P Morineau, V Reliquet, Solène Sécher, M Cavellec, A Soria, V Ferré, Elisabeth André‐Garnier, A Rodallec, Anne‐Marie Lefebvre, O Grossi, O Aubry, F. Raffi, P. Puglièse, S Bréaud, C Ceppi, D Chirio, Éric Cua, P Dellamonica, Élisa Demonchy, Anne De Monte, J. Durant, C Etienne, Stephen J. Ferrando, R Garraffo, C Michelangeli, V. Mondain, A Naqvi, N Oran, I. Perbost, Stéphane Pillet, C Pradier, B Prouvost-Keller, K Risso, V Rio, P.-M. Roger, E Rosenthal, S Sausse, I Touitou, S Wehrlen-Pugliese, G Zouzou, T Prazuck, C. Gubavu, A Sève, A Maka, C Boulard, Gladys Thomas, C Goujard, Yann Quertainmont, Elina Teicher, Nathalie Lerolle, O Deradji, Aurélie Barrail‐Tran, Roland Landman, V Joly, J Ghosn, C. Rioux, Sylvie Lariven, A. Gervais, F.-X. Lescure, Sophie Matheron, F Louni, Zélie Julia, C Mackoumbou-Nkouka, S Le Gac, C Charpentier, D. Descamps, G Peytavin, Y Yazdanpanah, Karima Amazzough, Véronique Avettand-Fènoël, Ghania Benabdelmoumen, P Bossi, G Cessot, C Charlier, Paul‐Henri Consigny, François Danion, Amélie Dureault, Julia Goesch, Romain Guéry, Bonnie Henry, Kaoutar Jidar, F Lanternier, Paul Loubet, O Lortholary, J Lourenco, P Parize, B Pilmis, F Touam, M.A. Valantin, R Tubiana, Rachid Agher, Sophie Seang, L Schneider, Romain Palich, Charles Alexandre Le Blanc, J. Berger, Yohan N’Guyen, D Lambert, I Kmiec, A Brunet, Véronique Brodard, Firouzé Bani‐Sadr, P Tattevin, M Revest, Faouzi Souala, M Baldeyrou, S Patrat-Delon, J.-M. Chapplain, François Bénézit, Magali Dupont, M Poinot, A Maillard, C Pronier, F. Lemaı̂tre, J P Sinteff, Élisabeth Botelho-Nevers, A. Frésard, V Ronat, F. Lucht, P Fischer, M Partisani, C Cheneau, M. Priester, Luc Batard, C Bernard-Henry, E de Mautort, Samira Fafi‐Kremer, D. Rey, Marco Antonio Álvarez, N Biezunski, Alexa Debard, Cyrille Delpierre, P Lansalot, L Lelièvre, Guillaume Martin‐Blondel, M Piffaut, L Porte, K Saune, Faïza Ajana, E Aïssi, I. Alcaraz, V Baclet, Laurence Bocket, Anne Boucher, P. Choisy, T. Huleux, B. Lafon-Desmurs, A Meybeck, M Pradier, N Viget, M Valette
15Citations signalées — pas une note de qualité
46Institutions déclarées
4Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: We assessed prevalence of multimorbidity (MM) according to year of human immunodeficiency virus (HIV) diagnosis in elderly people living with HIV (PLWH). METHODS: This was a cross-sectional study of MM in PLWH aged ≥70 years from the Dat'AIDS French multicenter cohort. MM was defined as at least 3 coexistent morbidities of high blood pressure, diabetes mellitus, osteoporosis, non-AIDS cancer, chronic renal failure, cardiovascular and cerebrovascular disease, obesity, undernutrition, or hypercholesterolemia. Logistic regression models evaluated the association between MM and calendar periods of HIV diagnosis (1983-1996, 1997-2006, and 2007-2018). The secondary analysis evaluated MM as a continuous outcome, and a sensitivity analysis excluded PLWH with nadir CD4 count <200 cells/μL. RESULTS: Between January 2017 and September 2018, 2476 PLWH were included. Median age was 73 years, 75% were men, median CD4 count was 578 cells/μL, and 94% had controlled viremia. MM prevalence was 71%. HBP and hypercholesterolemia were the most prevalent comorbidities. After adjustment for age, gender, smoking status, hepatitis C and hepatitis B virus coinfection, group of exposure, nadir CD4 count, CD4:CD8 ratio, and last CD4 level, calendar period of diagnosis was not associated with MM (P = .169). MM was associated with older age, CD4/CD8 ratio <0.8, and nadir CD4 count <200 cells/μL. Similar results were found with secondary and sensitivity analyses. CONCLUSIONS: MM prevalence was high and increased with age, low CD4/CD8 ratio, and nadir CD4 count <200 cells/μL but was not associated with calendar periods of HIV diagnosis. Known duration of HIV diagnosis does not seem to be a criterion for selecting elderly PLWH at risk of MM.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multimorbidity in Elderly Persons According to the Year of Diagnosis of Human Immunodeficiency Virus Infection: A Cross-sectional Dat’AIDS Cohort Study
- Date Crossref
- 09/12/2019
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
HIV-related health complications and treatmentsChronic Disease Management StrategiesHIV/AIDS Research and Interventions