Accès ouvert déclaré
2019
article
The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls
Jonathan R. I. Coleman, Héléna A. Gaspar, Julien Bryois, Enda M. Byrne, Andreas J. Forstner, Peter Holmans, Christiaan de Leeuw, Manuel Mattheisen, Andrew McQuillin, Jennifer M. Whitehead Pavlides, Stephan Ripke, Eli A. Stahl, Vassily Trubetskoy, Maciej Trzaskowski, Abdel Abdellaoui, Mark J. Adams, Annelie Nordin Adolfsson, Esben Agerbo, Diego Albani, Ney Alliey‐Rodriguez, Thomas D. Als, Till F. M. Andlauer, Verneri Antilla, Swapnil Awasthi, Silviu‐Alin Bacanu, Marie Bækvad‐Hansen, Nicholas Bass, Michael Bauer, Aartjan T.F. Beekman, Richard A. Belliveau, Tim B. Bigdeli, Elisabeth B. Binder, Erlend Bøen, Marco P. Boks, James Boocock, Henriette N. Buttenschøn, Jonas Bybjerg‐Grauholm, William Byerley, Miguel Casas, Felecia Cerrato, Pablo Cervantes, Kimberly Chambert, Alexander W. Charney, Danfeng Chen, Jane Christensen, Claire Churchhouse, Toni‐Kim Clarke, Lucía Colodro‐Conde, Baptiste Couvy‐Duchesne, Gregory E. Crawford, Cristiana Cruceanu, Piotr M. Czerski, Anders M. Dale, Jurgen Del‐Favero, J. Raymond DePaulo, Eske M. Derks, Neşe Direk, Srdjan Djurovic, Amanda Dobbyn, Thalia C. Eley, Torbjørn Elvsåshagen, Valentina Escott‐Price, Chun Chieh Fan, Hilary K. Finucane, Sascha B. Fischer, Matthew Flickinger, Tatiana Foroud, Liz Forty, Christine Fraser, Louise Frisén, Katrin Gade, Fernando S. Goes, Jaqueline Goldstein, Melissa J. Green, Tiffany A. Greenwood, Jakob Grove, Weihua Guan, Christine Søholm Hansen, Thomas Folkmann Hansen, Martin Hautzinger, Urs Heilbronner, Maria Hipolito, Per Hoffmann, Dominic Holland, Georg Homuth, Jouke‐Jan Hottenga, Laura M. Huckins, Marcus Ising, Stéphane Jamain, Rick Jansen, Jessica Johnson, Simone de Jong, Anders Juréus, Radhika Kandaswamy, James L. Kennedy, Farnush Farhadi Hassan Kiadeh, Sarah Kittel‐Schneider, James A. Knowles, Isaac S. Kohane, Anna C. Koller, Warren W. Kretzschmar, Jesper Krogh, Ralph Kupka, Zoltán Kutalik, William Lawson, Phil H. Lee, Jun Z. Li, Chunyu Liu, Loes M. Olde Loohuis, Anna Maaser, Donald J. MacIntyre, Dean F. MacKinnon, Pamela B. Mahon, Wolfgang Maier, Jonathan Marchini, Lina Martinsson, Steve McCarroll, Patrick J. McGrath, Helena Medeiros, Sarah E. Medland, Divya Mehta, Fan Meng, Christel M. Middeldorp, Yuri Milaneschi, Lili Milani, Saira Saeed Mirza, Francis M. Mondimore, Derek W. Morris, Thomas W. Mühleisen, Niamh Mullins, Matthias Nauck, Caroline M. Nievergelt, Michel G. Nivard, Evaristus Nwulia, Dale R. Nyholt, Paul F. O’Reilly, Anil P. S. Ori, Lilijana Oruč, Urban Ösby, Högni Óskarsson, Jodie N. Painter, José Guzmán‐Parra, Amy Perry, Roseann E. Peterson, Erik Pettersson, Wouter J. Peyrot, Andrea Pfennig, Giorgio Pistis, Shaun Purcell, Per Qvist, Eline J. Regeer, Céline S. Reinbold, John P. Rice, Brien P. Riley, Fabio Rivas, Margarita Rivera, Panos Roussos, Douglas M. Ruderfer, Euijung Ryu, Alan F. Schatzberg, William A. Scheftner, Robert A. Schoevers, Nicholas J. Schork, Eva C. Schulte, Tatyana Shehktman, Jianxin Shi, Stanley I. Shyn, Engilbert Sigurðsson, Olav B. Smeland, Johannes H. Smit, Janet L. Sobell, Anne T. Spijker, Michael Steffens, John S. Strauss, Fabian Streit, Henning Teismann, Alexander Teumer, Robert C. Thompson, Wesley K. Thompson, Pippa A. Thomson, Thorgeir E. Thorgeirsson, Matthew Traylor, Jens Treutlein, André G. Uitterlinden, Daniel Umbricht, Helmut Vedder, Weiqing Wang, Bradley T. Webb, Cynthia Shannon Weickert, Thomas W. Weickert, Shantel Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Stephanie H. Witt, Yang Wu, Hualin Simon Xi, Jian Yang, Allan H. Young, Peter P. Zandi, Peng Zhang, Futao Zhang, Sebastian Zöllner, Rolf Adolfsson, Ingrid Agartz, Martin Alda, Volker Arolt, Lena Backlund, Frank Bellivier, Wade H. Berrettini, Joanna M. Biernacka, Michael Boehnke, Aiden Corvin, Nicholas Craddock, Mark J. Daly, Udo Dannlowski, Enrico Domenici, Katharina Domschke, Tõnu Esko, Janice M. Fullerton, Elliot S. Gershon, Eco J. C. de Geus, Michael Gill, Maria Grigoroiu‐Serbânescu, Joanna Hauser, Caroline Hayward, David M. Hougaard, Christina M. Hultman, Ian Jones, Lisa Jones, René S. Kahn, Kenneth S. Kendler, George Kirov, Stefan Kloiber, Mikael Landén, Marion Leboyer, Glyn Lewis, Qingqin S. Li, Jolanta Lissowska, Susanne Lucae, Patrik K. E. Magnusson, Nicholas G. Martin, Susan L. McElroy, Andrew M. McIntosh, Francis J. McMahon, Ingrid Melle, Philip B. Mitchell, Gunnar Morken, Ole Mors, Preben Bo Mortensen, Bertram Müller-Myhsok, Benjamin M. Neale, Merete Nordentoft, Markus M. Nöthen, Michael O‘Donovan, Ketil J. Øedegaard, Michael J. Owen, Sara A. Paciga, Carlos N. Pato, Michele T. Pato, Nancy L. Pedersen, Roy H. Perlis, David J. Porteous, Daniëlle Posthuma, Josep Antoni Ramos‐Quiroga, Marcella Rietschel, Guy A. Rouleau, Peter R. Schofield, Alessandro Serretti, Jordan W. Smoller, Hreinn Stefánsson, Eystein Stordal, Henning Tiemeier, Gustavo Turecki, Rudolf Uher, Eduard Vieta, Henry Völzke, Thomas Werge, Ole A. Andreassen, Anders D. Børglum, Sven Cichon, Howard J. Edenberg, Arianna Di Florio, John R. Kelsoe, Cathryn M. Lewis, Roel A. Ophoff, Pamela Sklar, Patrick F. Sullivan, Naomi R. Wray, Weihua Guan, Gerome Breen
212Citations signalées, ce qui n’est pas une note de qualité
3Institutions déclarées
2Pays d’affiliation déclarés
Rattachement africain : gb, se.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction. METHODS: To clarify the shared molecular genetic basis of major depressive disorder and bipolar disorder and to highlight disorder-specific associations, we meta-analyzed data from the latest Psychiatric Genomics Consortium genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; nonoverlapping N = 609,424). RESULTS: Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 that are novel for mood disorders. More loci from the Psychiatric Genomics Consortium analysis of major depression than from that for bipolar disorder reached genome-wide significance. Genetic correlations revealed that type 2 bipolar disorder correlates strongly with recurrent and single-episode major depressive disorder. Systems biology analyses highlight both similarities and differences between the mood disorders, particularly in the mouse brain cell types implicated by the expression patterns of associated genes. The mood disorders also differ in their genetic correlation with educational attainment-the relationship is positive in bipolar disorder but negative in major depressive disorder. CONCLUSIONS: The mood disorders share several genetic associations, and genetic studies of major depressive disorder and bipolar disorder can be combined effectively to enable the discovery of variants not identified by studying either disorder alone. However, we demonstrate several differences between these disorders. Analyzing subtypes of major depressive disorder and bipolar disorder provides evidence for a genetic mood disorders spectrum.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls
- Date Crossref
- 01/07/2020
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Genetic Associations and EpidemiologyBipolar Disorder and TreatmentTryptophan and brain disorders