Hualin Simon Xi

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

Peter M. Visscher, Ole N Mors, Isaac S. Kohane, Christine Søholm Hansen et autres

Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings …

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CRISPR-based shuttle cloning of 1397 human genes into UAS vectors

Xuelian Liu, Hualin Simon Xi, Miao Dai, Xiaoxue Li et autres

cn (code pays fourni par la source)

CRISPR-based shuttle cloning of 1,397 human genes into UAS vectors

Xuelian Liu, Hualin Simon Xi, Miao Dai, Xiaoxue Li et autres

ABSTRACT The construction of genome-wide DNA libraries from publicly available resources is essential for leveraging functional genomics to investigate complex biological systems. However, all existing high-throughput cloning methods for transferring DNA fragments between vectors require PCR amplification of the DNA fragments, rendering …

cn (code pays fourni par la source)

[Preliminary study on the role and mechanism of IL-6 receptor antagonists in improving post-infarction ventricular arrhythmia].

Qinfang Qiu, Cheng Peng, Z Y Li, Xiangyang Xu et autres

TCZ may reduce neural activity of the SCG after MI by inhibiting the IL-6/STAT3 signaling pathway, thereby alleviating myocardial injury and inhibiting VAs.

cn (code pays fourni par la source)

Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability

Xiaotong Wang, Alicia Walker, Joana Revez, Guiyan Ni et autres

au, gb (code pays fourni par la source)

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Yu-Han H. Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu et autres

Genetics have nominated many schizophrenia risk genes and identified convergent signals between schizophrenia and neurodevelopmental disorders. However, functional interpretation of the nominated genes in the relevant brain cell types is often lacking. We executed interaction proteomics for six schizophrenia risk genes that …

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Data from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer

Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav et autres

Abstract We show that the VEGF receptor neuropilin-2 (NRP2) is associated with high-grade, PTEN-null prostate cancer and that its expression in tumor cells is induced by PTEN loss as a consequence of c-Jun activation. VEGF/NRP2 signaling represses insulin-like growth factor-1 receptor (IGF-IR) …

Data from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer

Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav et autres

Abstract We show that the VEGF receptor neuropilin-2 (NRP2) is associated with high-grade, PTEN-null prostate cancer and that its expression in tumor cells is induced by PTEN loss as a consequence of c-Jun activation. VEGF/NRP2 signaling represses insulin-like growth factor-1 receptor (IGF-IR) …

Supplementary Figure 1 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer

Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav et autres

PDF file - 536K, Invasive behavior of cell lines used and assessment of NRP2 expression in prostate glands and cancer

Supplementary Figure 4 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer

Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav et autres

PDF file - 454K, Role of JNK/c-Jun in regulating NRP2 expression in prostate carcinoma cells

Supplementary Figure 2 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer

Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav et autres

PDF file - 2.5MB, Correlation of NRP2 expression in prostate cancer with clinical parameters and expression of VEGFRs

Supplementary Figure 7 from VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer

Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav et autres

PDF file - 504K, Response of xenografts of human prostate cancer specimens to IGF-1R inhibition as a function of NRP2 expression