Accès ouvert déclaré
2020
article
The Somatic Genomic Landscape of Glioblastoma
Lynda Chin, Todd Pihl, Bikash Bose, Yuexin Liu, Jennifer Mary Eschbacher, Jill S. Barnholtz‐Sloan, Scott R. Van Den Berg, Benito Campos, Ken Chen, Julia Y. Ljubimova, Yevgeniy Antipin, Jaegil Kim, Mary Iacocca, Debyani Chakravarty, Yonghong Xiao, Kenna R Mills Shaw, Chris Sander, Theodore C. Goldstein, Cameron Brennan, Jianhua Zhang, Gordon Saksena, Michael E. Berens, Peng Chieh Chen, Eric S. Lander, Ryan Bressler, Peter J. Park, Lisa M. Scarpace, Kristin Ardlie, Christopher C. Benz, Rui Jing, Michael D. Topal, Bianca Pollo, Phillip H. Lai, Sofie R. Salama, Giovanni Ciriello, Samuel Berman, Brian Craft, Alexei I. Protopopov, Patricia Swanson, Junyuan Wu, Narra Sarojini Devi, Brenda Ayala, Stacey L. Gabriel, Marco Saini, Ching C. Lau, Pawan Rastogi, Jianjiong Gao, Anthony T. Yachnis, Jerome Myers, Mary J. Goldman, Mark L. Cohen, David W. Mallery, Ling Li, Steve Schumacher, Ronglai Shen, Lucinda Fulton, Jeffrey J. Olson, Daniel J. Weisenberger, Bülent Arman Aksoy, Erin E. Curley, Kelly J. Tucker, Keith L. Black, Robert James Penny, Will Mallard, Brian P O'Neill, Biaoyang Lin, Kalle Leinonen, W. K. Alfred Yung, Sachet Ashok Shukla, Karen Devine, Zhaobin Zhang, Rameen Beroukhim, Semin Lee, Jing Zhu, Madgy Boulos, Giannicola Genovese, Tanja M. Davidsen, Singer Ma, Kennedy Yalamanchii, Ethan G Cerami, Richard F. Wilson, Ari E. Kahn, Peter Waltman, David Pot, Nikolaus D. Schultz, Abhijit Ranjan Guha, Andrew D. Cherniack, Zack Sanborn, Darell D. Bigner, Laura A. L. Dillon, Kyle Ellrott, Kenneth Aldape, Mike Noble, Mark S. Guyer, Jonathan G. Seidman, Mark E. Sherman, Joshua M. Stuart, Qing Rong Chen, Daniel DiCara, Paul T. Boulos, Katherine A. Hoadley, Daniel J. Brat, Marica Eoli, Andrea Eakin, David Neil Hayes, Aditya Raghunathan, Steven N. Kalkanis, Ilana P. Otey, Robert S. Fulton, Teresa Kitko, Laila Poisson, John A. Eckman, Wei Zhang, Richard K. Wilson, Christine Czerinski, Martin L. Ferguson, Vésteinn Thórsson, David Van Den Berg, Roy W Tarnuzzer, Juok Cho, Paul T. Spellman, Hailei Zhang, Mitchel Stuart Berger, Tom Mikkelsen, Yunhu Wan, Jodi L. Harr, Alex Lash, John N. Weinstein, Barbara H. Frentzen, Gena M. Mastrogianakis, Lucia Cuppini, Gregory N. Fuller, Teresa Swatloski, Emanuela Maderna, Scott L. Carter, Wenbin Liu, Nils Gehlenborg, Sam Ng, Carrie L. Sougnez, Raquel G. McTiernan, Lihua Zou, Erwin G. Van Meir, David I. Heiman, Timothy J. Triche, Saianand Balu, Scott Frazer, Norman L. Lehman, Nathan Hansen, Stephen B. Baylin, Troy Shelton, Quinn T. Ostrom, Siyuan Zheng, Matti Annala, Liming Yang, Peggy Yena, Petar Stojanov, Lisa E. Iype, Heidi J. Sofia, Nathan N. Dees, Lixing Yang, Jae Geun Yoon, Yong Mao, Brady M. Bernard, Matthew Eppley, David William Andrews, Gad Getz, Scott J. Morris, Robin M. Foss, Greg D. Eley, Pei Lin, Nicholas D. Socci, Rahulsimham Vegesna, Michael C. Sugarman, Peter W. Laird, Richard A. Gibbs, J. Todd Auman, Bradley A. Ozenberger, Thelma Kempista, Yingli Wolinsky, Doug Voet, Kristian Cibulskis, Joseph D. Paulauskis, Andrew Edward Sloan, Yiling Lu, Raju Kucherlapati, Eunjung Lee, Jenn Brown, Aaron McKenna, William A. Friedman, Mia Grifford, Marc Ladanyi, Marco A. Marra, Ilya Shmulevich, Yingchun Spring Liu, Larry A. Harshyne, Parvi Hothi, Chang Wu, Leigh Anne Zach, Elaine R. Mardis, Mark A. Jensen, Charles M. Perou, Michael S. Lawrence, Roel G.W. Verhaak, Margi Sheth, Youting Sun, Jun Li, Yan Shi, Houtan Noushmehr, Boris A. Reva, Michael D. Prados, Richard Kreisberg, Hector Rovira, Martha Hatfield, David H. Haussler, Gavin P. Dunn, Eric Lipp, Yakov Koyfman, Matthew M. Meyerson, Krishna Kanchi, Yupu Liang, Brenda Rabeno, Xiaojia Ren, Julie Bergsten, C. Ryan Miller, Gordon B. Mills, Benjamin E Gross, David H. Gutmann, Rehan Akbani, Candace Shelton, Caterina Giannini, Jeff Gentry, Sheila M. Reynolds, Angela G. Hadjipanayis, John A. Demchok, Francesco DiMeco, Cindy Winemiller, Greg Foltz, Christine Smith, Wendi Barrett, Oliver Bögler, Andrew Sloan, Roger E. McLendon, Robert C. Onofrio, Gaetano Finocchiaro, Nameeta Shah, Agnes J. Viale, Barbara Tabak, Laetitia A Borsu
0Citations signalées, ce qui n’est pas une note de qualité
1Institutions déclarées
1Pays d’affiliation déclarés
Rattachement africain : us.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
We describe the landscape of somatic genomic alterations based on multi-dimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors including EGFR and PDGFRA. TERT promoter mutations are shown to correlate with elevated mRNA expression, supporting a role in telomerase reactivation. Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM. Integrative analysis of genomic and proteomic profiles challenges the notion of therapeutic inhibition of a pathway as an alternative to inhibition of the target itself. These data will facilitate the discovery of therapeutic and diagnostic target candidates, the validation of research and clinical observations and the generation of unanticipated hypotheses that can advance our molecular understanding of this lethal cancer.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
La source scientifique ouverte est momentanément indisponible.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Glioma Diagnosis and Treatment