Brenda Rabeno

Integrated genomic analyses of ovarian carcinoma

Quaid Morris, Pat Glenn, Michael J. Birrer, Nicholas J. Petrelli et autres

SummaryThe Cancer Genome Atlas (TCGA) project has analyzed mRNA expression, miRNA expression, promoter methylation, and DNA copy number in 489 high-grade serous ovarian adenocarcinomas (HGS-OvCa) and the DNA sequences of exons from coding genes in 316 of these tumors. These results show …

The Somatic Genomic Landscape of Glioblastoma

Lynda Chin, Todd Pihl, Bikash Bose, Yuexin Liu et autres

We describe the landscape of somatic genomic alterations based on multi-dimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors including EGFR and PDGFRA. TERT promoter mutations …

us (code pays fourni par la source)

The Immune Landscape of Cancer

Vésteinn Thórsson, David L. Gibbs, Scott D. Brown, Denise M. Wolf et autres

(Immunity 48, 812–830.e1–e14; April 17, 2018) In the originally published version of this article, the authors neglected to include Younes Mokrab and Aaron M. Newman as co-authors and misspelled the names of authors Charles S. Rabkin and Ilya Shmulevich. The author names …

us, ca, es, be, qa, br (code pays fourni par la source)

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

Yumeng Wang, Xiaoyan Xu, Dejan Maglic, Michael T. Dill et autres

Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genome Atlas. We identify …

us, cn (code pays fourni par la source)

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

Sobia Zaidi, Rupa S. Kanchi, Shuyun Rao, Nancy R. Gough et autres

We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode mediators and regulators of TGF-β signaling, we …

us, ca, es, dk, pl, mo (code pays fourni par la source)

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

André Kahles, Kjong-Van Lehmann, Nora C. Toussaint, Matthias Hüser et autres

Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detects alternative splicing events and tumor variants by reanalyzing RNA and whole-exome sequencing data. Tumors have up to 30% more alternative splicing events than normal …

ch, us, de, gb (code pays fourni par la source)

Comprehensive Characterization of Cancer Driver Genes and Mutations

Matthew H. Bailey, Collin Tokheim, Eduard Porta‐Pardo, Sohini Sengupta et autres

(Cell 173, 371–385.e1–e9; April 5, 2018) It has come to our attention that we made two errors in preparation of this manuscript. First, in the STAR Methods, under the subheading of “Hypermutators and Immune Infiltrates” within the “Quantification and Statistical Analysis” section, …

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

Zehua Wang, Bo Yang, Min Zhang, Weiwei Guo et autres

We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation of 1,006 lncRNA genes in cancer, …

us (code pays fourni par la source)

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

Xinxin Peng, Zhongyuan Chen, Farshad Farshidfar, Xu Xiaoyan et autres

Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven major metabolic processes and assessed their clinical …

us, ca, cn (code pays fourni par la source)

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

Ashton C. Berger, Anil Korkut, Rupa S. Kanchi, Apurva M. Hegde et autres

We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations …

us, se, be, ca, br, Nigéria, tw, au (code pays fourni par la source)

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

Alison M. Taylor, Juliann Shih, Xiaoyang Zhang, Ashton C. Berger et autres

Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of proliferation genes. Aneuploidy was anti-correlated with expression …

us (code pays fourni par la source)

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

Yang Liu, Nilay S. Sethi, Toshinori Hinoue, Barbara Schneider et autres

We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with …

us, ca, be (code pays fourni par la source)