Accès ouvert déclaré
2019
article
Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study
Elizabeth Chappell, Andrew Riordan, Gonzague Jourdain, Antoni Soriano‐Arandes, Luminita Ene, Henriëtte J. Scherpbier, Josiane Warszawski, Intira Jeannie Collins, Colette Smit, Laura Marques, Nigel Klein, Sara Guillén, Ali Judd, Claire Thorne, Ruth Goodall, Christoph Königs, Vana Spoulou, Filipa Prata, Tessa Goetghebuer, Elena Chiappini, Luisa Galli, Lars Navér, Carlo Giaquinto, Diana M Gibb, Magdalena Marczyńska, Liubov Okhonskaia, Thomas Klimkait, Marc Lallemant, Nicole Ngo‐Giang‐Huong, Galyna Kiseleva, Ruslan Malyuta, Алла Волоха, Marc Hainaut, Marc Delforge, Jérôme Le Chenadec, Elisa Diana Ruiz Ramos, Olivia Dialla, Thierry Wack, Corine Laurent, Lamya Ait Si Selmi, Isabelle Leymarie, Fazia ait Benali, Maud Brossard, Leila Boufassa, Corinne Floch-Tudal, Ghislaine Firtion, Isabelle Hau, Anne Chacé, Pascal Bolot, Stéphane Blanche, Martine Levine, Le Kremlin Bicêtre, Corinne Fourcade, Brigitte Heller-Roussin, Camille Runel-Belliard, J Tricoire, Catherine Chirouze, Véronique Reliquet, Jacques Brouard, Kamila Kébaïli, Pascale Fialaire, Muriel Lalande, Stephan Schultze-Strasser, U Baumann, T Niehues, Jennifer Neubert, Robin Kobbe, Charite Berlin, Cornelia Feiterna‐Sperling, C Königs, B. Buchholz, Gundula Notheis, Maurizio de Martino, Pier‐Angelo Tovo, Osimani Patrizia, Domenico Larovere, Maurizio Ruggeri, Giacomo Faldella, Francesco Baldi, Raffaele Badolato, Carlotta Montagnani, Elisabetta Venturini, Catiuscia Lisi, Antonio Di Biagio, Lucia Taramasso, Vania Giacomet, Paola Erba, Susanna Esposito, Rita Lipreri, Filippo Salvini, Claudia Tagliabue, Monica Cellini, Eugenia Bruzzese, Andrea Lo Vecchio, Osvalda Rampon, Daniele Donà, Amelia Romano, Icilio Dodi, Anna Maccabruni, Rita Consolini, Stefania Bernardi, Hyppolite Tchidjou Kuekou, Orazio Genovese, Paolina Olmeo, Letizia Cristiano, Antonio Mazza, Clara Gabiano, Silvia Garazzino, Antonio Pellegatta, Dasja Pajkrt, Annouschka M. Weijsenfeld, Cindy G. Boer, Suzanne Jurriaans, Nicole Back, Hans L. Zaaijer, B. Berkhout, Marion Cornelissen, C. Schinkel, Katja C. Wolthers, Pieter L. A. Fraaij, Annemarie M. C. van Rossum, Linda C. van der Knaap, Eline G. Visser, Marion Koopmans, J J A van Kampen, Suzan D. Pas, Stefanie Henriet, M van de Flier, Koen van Aerde, R. Strik-Albers, Janette Rahamat‐Langendoen, Foekje F. Stelma, Elisabeth H. Schölvinck, H. de Jonge, Hubert G.M. Niesters, Coretta van Leer‐Buter, Marjolein Knoester, Louis Bont, Sibyl P. M. Geelen, Tom F.W. Wolfs, N Nauta, C. Wim Ang, Robin van Houdt, A M Pettersson, Christina M. J. E. Vandenbroucke‐Grauls, Peter Reiss, Daniela Bezemer, A.I. van Sighem, F W M N Wit, T. Sonia Boender, S Zaheri, M Hillebregt, A. de Jong, D.P. Bergsma, S Grivell, Angelique C.M. Jansen, M Raethke, Roelien A. M. Meijering, L de Groot, M van den Akker, Y. Bakker, E Claessen, A el Berkaoui, Judith C. Koops, E Kruijne, C Lodewijk, L Munjishvili, B Peeck, Cornelis L. P. van de Ree, R. Regtop, Y M C Ruijs, T. Rutkens, Maartje Schoorl, A Timmerman, E Tuijn, L Veenenberg, Stefan van der Vliet, Agatha Wisse, T Woudstra, Bert Tuk, Jolanta Popielska, Maria Pokorska‐Śpiewak, Agnieszka Ołdakowska, Konrad Zawadka, Urszula Coupland, Małgorzata DorobaLaura Marques, Carla Teixeira, Alexandre Fernandes, Evgeny Voronin, Milana Miloenko, Svetlana Labutina, José Tomás Ramos, Luís Prieto, María Luisa Navarro, Jesús Saavedra, Mar Santos, M. Angeles Muñoz, Beatriz Ruiz, Carolina Fernandez Mc Phee, Santiago Jiménez de Ory, Susana Alvarez, Miguel Ángel Roa, José Beceiro, Jorge Martínez, Katie Badillo, Miren Apilanez, Itziar Pocheville, Elisa Garrote, Elena Colino, Jorge Gómez Sirvent, M. González-Ripoll Garzón, Vicente Román, Abián Montesdeoca, M. Gracia Mateo, María José Muñoz, Raquel Angulo, Olaf Neth, Lola Falcón-Neyra, Pedro Terol, Juan Luis Santos, David Moreno, Francisco Lendínez, Ana Grande, Francisco José Romero, Miguel Lillo, Begoña Losada, Mercedes Herranz, Matilde Bustillo Alonso, Carmelo Guerrero, Pilar Collado, José Antonio Couceiro, Amparo Pérez, Ana Isabel Piqueras, Rafael Bretón, Inmaculada Segarra, César Gavilán, Enrique J. Jareño, Elena Montesinos, Marta Dapena, Cristina Álvarez, Ana Gloria Andrés, Víctor Marugán, Carlos Ochoa, Santiago Alfayate, Ana Isabel Menasalvas, Elisa de Miguel, Karoline Aebi‐Popp, Sandra Asner, V Aubert, Manuel Battegay, Michèle Baumann, E Bernasconi, J Böni, Pierluigi Brazzola, H C Bucher, Alexandra Calmy, Matthias Cavassini, A Ciuffi, Andrea Duppenthaler, G Dollenmaier, Matthias Egger, L Elzi, J Fehr, Jacques Fellay, Katyuska Francini, Hansjakob Furrer, Christoph A. Fux, Claudia Grawe, Huldrych F. Günthard, D Haerry, Barbara Hasse, Hans H. Hirsch, M Hoffmann, Irène Hösli, Christoph Kahlert, L Kaiser, Olivia Keiser, Thomas Klimkait, H Kovari, Roger D. Kouyos, Bruno Ledergerber, G Martinetti, Begoña Martínez de Tejada, K J Metzner, N Müller, Dunja Nicca, P Paioni, G Pantaleo, Ch Polli, Klara M. Posfay‐Barbe, Alan Rauch, Charles M. Rudin, Patrick Schmid, Alexandra Scherrer, Roberto F. Speck, Philip Tarr, Mariah Lecompte, A Trkola, P Vernazza, Noémie Wagner, Gilles Wandeler, R Weber, Claire‐Anne Wyler, S Yerly, Pornchai Techakunakorn, Rawiwan Hansudewechakul, C. Kham, Vanichaya Wanchaitanawong, Sookchai Theansavettrakul, M. Kalyan Sai, Sirisak Nanta, Chaiwat Ngampiyaskul, Siriluk Phanomcheong, Suchat Hongsiriwon, Warit Karnchanamayul, Ratchanee Kwanchaipanich, Suparat Kanjanavanit, Nareerat Kamonpakorn, Maneeratn Nantarukchaikul, Prapaisri Layangool, Jutarat Mekmullica, Paiboon Lucksanapisitkul, Sudarat Watanayothin, Narong Lertpienthum, Boonyarat Warachit, Sansanee Hanpinitsak, Sathit Potchalongsin, Pimpraphai Thanasiri, Sawitree Krikajornkitti, Pornsawan Attavinijtrakarn, Sakulrat Srirojana, Suthunya Bunjongpak, Achara Puangsombat, Sathaporn Na-Rajsima, Pornchai Ananpatharachai, Noppadon Akarathum, Vachira Phuket, Weerasak Lawtongkum, Prapawan Kheunjan, Thitiporn Suriyaboon, Airada Saipanya, Kanchana Than-in-at, Nirattiya Jaisieng, Rapeepan Suaysod, Sanuphong Chailoet, Naritsara Naratee, Suttipong Kawilapat, T Kaleeva, Y Baryshnikova, S Soloha, N Bashkatova, Irina Raus, O Glutshenko, Z Ruban, N Prymak, Galina Kiseleva, Heather Bailey, Alasdair Bamford, Karina Butler, Katja Doerholt, Conor Doherty, Caroline Foster, Kate Francis, Ian Harrison, Julia Kenny, Gillian Letting, Paddy McMaster, Fungai Murau, Edith Nsangi, Helen Peters, Katia Prime, Fiona Shackley, Delane Shingadia, Sharon Storey, Gareth Tudor‐Williams, Anna Turkova, Steve Welch, Claire Cook, Siobhan Crichton, Donna Dobson, Keith Fairbrother, Lynda Harper, Marthe Le Prevost, Nadine Van Looy, A Walsh, Laura Thrasyvoulou, Jolanta Bernatoniene, F Manyika, G Sharpe, Barathi Subramaniam, K S Sloper, Katy Fidler, R A Hague, V Price, M Clapson, J. Norman Flynn, Adílson Lopes Cardoso, M Abou–Rayyah, D Gurtin, S Yeadon, S Segal, C Ball, Sarah Hawkins, Maria Dowie, Srini Bandi, Elizabeth Percival, M Eisenhut, Karsten Duncan, Stacey Clough, L Anguvaa, Susan R. Conway, Timothy J. Flood, A Pickering, P McMaster, Cynthia Murphy, Julie T. Daniels, Y Lees, F Thompson, B Williams, Susan Pope, L Cliffe, A Smyth, S Southall, A Freeman, H P Freeman, Sarah Christie, Alexander Gordon, D Rogahn, Linda Clarke, Laura Jones, B Offerman, Michael E. Greenberg, Carmela Benson, L Ibberson, Saul N. Faust, Jane Hancock, Mike Sharland, Hermione Lyall, C. Monrose, Paula Seery, Esse Menson, Ann Callaghan, A Bridgwood, P McMaster, John Evans, Erin A. Blake, A Yannoulias, E W Chappell, Siobhan Critchton, Charlotte Duff, Daniel Gomez-Pena, Rebecca Lundin, Laura Mangiarini, Alessandra Nardone, Claire Thorne
15Citations signalées — pas une note de qualité
41Institutions déclarées
9Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: In human immunodeficiency virus (HIV)-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART. METHODS: Sixteen cohorts from the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) contributed data. Children <18 years at ART initiation, with sustained viral suppression (VS) (≤400 copies/mL) for ≥1 year were included. The prevalence of PIR (defined as World Health Organization advanced/severe immunosuppression for age) at 1 year of VS was described. Factors associated with PIR were assessed using logistic regression. Rates of acquired immunodeficiency syndrome (AIDS) or death on suppressive ART were calculated by PIR status. RESULTS: Of 2318 children included, median age was 6.4 years and 68% had advanced/severe immunosuppression at ART initiation. At 1 year of VS, 12% had PIR. In multivariable analysis, PIR was associated with older age and worse immunological stage at ART start, hepatitis B coinfection, and residing in Thailand (all P ≤ .03). Rates of AIDS/death (95% confidence interval) per 100 000 person-years were 1052 (547, 2022) among PIR versus 261 (166, 409) among immune responders; rate ratio of 4.04 (1.83, 8.92; P < .001). CONCLUSIONS: One in eight children in our cohort experienced PIR despite sustained VS. While the overall rate of AIDS/death was low, children with PIR had a 4-fold increase in risk of event as compared with immune responders.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study
- Date Crossref
- 28/03/2019
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
HIV/AIDS Research and InterventionsHIV Research and TreatmentHIV/AIDS drug development and treatment