Accès ouvert déclaré
2018
article
Germline variation at 8q24 and prostate cancer risk in men of European ancestry
Marco Matejcic, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Kan Wang, Xin Sheng, Ali Amin Al Olama, Fredrick R. Schumacher, Sue A. Ingles, Koveela Govindasami, Sara Benlloch, Sonja I. Berndt, Demetrius Albanes, Stella Koutros, Kenneth Muir, Victoria L. Stevens, Susan M. Gapstur, Catherine M. Tangen, Jyotsna Batra, Judith A. Clements, Henrik Grönberg, Nora Pashayan, Johanna Schleutker, Alicja Wolk, Catharine West, Lorelei A. Mucci, Peter Kraft, Géraldine Cancel‐Tassin, Karina D. Sørensen, Lovise Mæhle, Eli Marie Grindedal, Sara S. Strom, David E. Neal, Freddie C. Hamdy, Jenny Donovan, Ruth C. Travis, Robert J. Hamilton, Barry S. Rosenstein, Yong‐Jie Lu, Graham G. Giles, Adam S. Kibel, Ana Vega, J.T. Bensen, Manolis Kogevinas, Kathryn L. Penney, Jong Y. Park, Janet L. Stanford, Cezary Cybulski, Børge G. Nordestgaard, Hermann Brenner, Christiane Maier, Jeri Kim, Manuel R. Teixeira, Susan L. Neuhausen, Kim De Ruyck, Azad Hassan Abdul Razack, Lisa F. Newcomb, Davor Lessel, Radka Kaneva, Nawaid Usmani, Frank Claessens, Paul A. Townsend, Manuela Gago-Domínguez, Monique J. Roobol, F. Ménégaux, Kay‐Tee Khaw, Lisa Cannon‐Albright, Hardev Pandha, Stephen N. Thibodeau, Daniel J. Schaid, B. E. Henderson, Mariana C. Stern, Alison Thwaites, Michelle Guy, Ian Whitmore, Angela Morgan, Cyril Fisher, Steve Hazel, Naomi Livni, Margaret Cook, Laura Fachal, Stephanie J. Weinstein, Laura E. Beane Freeman, Robert N. Hoover, Mitchell J. Machiela, Artitaya Lophatananon, Brian D. Carter, Phyllis J. Goodman, Leire Moya, Srilakshmi Srinivasan, Mary‐Anne Kedda, Trina Yeadon, Allison Eckert, Martin Eklund, Carin Cavalli-Bjoerkman, Alison M. Dunning, Csilla Sipeky, Niclas Håkansson, Rebecca Elliott, Hardeep Ranu, Edward L. Giovannucci, Constance Turman, David J. Hunter, Olivier Cussenot, Torben F. Ørntoft, J. Athene Lane, Sarah J. Lewis, Michael S. Davis, Tim Key, Paul Brown, Girish S. Kulkarni, Alexandre R. Zlotta, Neil E. Fleshner, Antonio Finelli, Xueying Mao, Jacek Marzec, Robert J. MacInnis, Roger Milne, John L. Hopper, Miguel Aguado, Mariona Bustamante, Gemma Castaño‐Vinyals, Esther Gràcia‐Lavedan, Lluís Cecchini, Meir J. Stampfer, Jing Ma, Thomas A. Sellers, Milan S. Geybels, Hyun Jung Park, Babu Zachariah, Suzanne Kolb, Dominika Wokołorczyk, Jan Lubiński, Wojciech Kluźniak, Sune F. Nielsen, Maren Weisher, Katarina Ćuk, Walther Vogel, Manuel Luedeke, Christopher J. Logothetis, Paula Paulo, Marta Cardoso, Sofia Maia, María P. Silva, Linda Steele, Yuan Chun Ding, Gert De Meerleer, Sofie De Langhe, Hubert Thierens, Jasmine Lim, Meng H. Tan, Aik T. Ong, Darina Kachakova, A. Mitkova, Vanio Mitev, Matthew Parliament, Guido Jenster, Christopher Bangma, Fritz H. Schröder, Thérèse Truong, Yves Akoli Koudou, Agnieszka Michael, Andrzej Kierzek, Ami Karlsson, Michael Broms, Huihai Wu, Claire Aukim-Hastie, Lori S. Tillmans, Shaun M. Riska, Shannon K. McDonnell, David Dearnaley, Amanda B. Spurdle, Robert A. Gardiner, Vanessa M. Hayes, Lisa M. Butler, Renea A. Taylor, Melissa Papargiris, Pâmela Saunders, Paula Kujala, Kirsi Talala, Kimmo Taari, Søren M. Bentzen, Belynda Hicks, Aurélie Vogt, Amy Hutchinson, Angela Cox, Anne George, Ants Toi, Andrew Evans, Theodorus van der Kwast, Takashi Imai, Shiro Saito, Shan‐Chao Zhao, Guoping Ren, Yangling Zhang, Yongwei Yu, Yudong Wu, Ji Wu, Bo Zhou, John Pedersen, Ramón Lobato-Busto, José Manuel Ruiz-Dominguez, Lourdes Mengual, Antonio Alcaraz, Julio M. Pow‐Sang, Kathleen Herkommer, Tihomir Dikov, S. Christova, Ãngel Carracedo, Brigitte Trétarre, Xavier Rébillard, Claire Mulot, Jan Adolfsson, Pär Stattin, Jan-Erik Johansson, Richard M. Martin, Ian M. Thompson, Suzanne K. Chambers, Joanne F. Aitken, Lisa Horvath, Anne‐Maree Haynes, Wayne D. Tilley, Gail P. Risbridger, Markus Aly, Tobias Nordström, Paul D.P. Pharoah, Teuvo L.J. Tammela, Teemu J. Murtola, Anssi Auvinen, Neil Burnet, Gill Barnett, Gerald L. Andriole, Aleksandra Klim, Bettina F. Drake, Michael Borre, Harry Ostrer, Hong-Wei Zhang, Guangwen Cao, Ji Lin, Jin Ling, Meiling Li, Ninghan Feng, Jie Li, Weiyang He, Xin Guo, Zan Sun, Guomin Wang, Jianming Guo, Melissa C. Southey, Liesel M. FitzGerald, Gemma Marsden, Antonio Gómez‐Caamaño, Ana M. Carballo, Paula Peleteiro, Patricia Calvo, Robert Szulkin, Javier Llorca, Trinidad Dierssen-Sotos, Inés Gómez‐Acebo, Hui‐Yi Lin, Elaine A. Ostrander, Rasmus Bisbjerg, Peter Klarskov, Martin Andreas Røder, Peter Kr. Iversen, Bernd Holleczek, Christa Stegmaier, Thomas Schnoeller, Philipp Bohnert, Esther M. John, Piet Ost, Soo‐Hwang Teo, Marija Gamulin, Tomislav Kuliš, Zeljko Kastelan, Chavdar Slavov, Elenko Popov, Thomas Van den Broeck, Steven Joniau, Samantha Larkin, Jose E. Castelao, Marı́a Elena Martı́nez, Ron H. N. van Schaik, Jianfeng Xu, Sara Lindström, Elio Ríboli, Clare Berry, Afshan Siddiq, Federico Canzian, Laurence N. Kolonel, Loïc Le Marchand, Matthew L. Freedman, Sylvie Cénée, Fredrik Wiklund, Stephen J. Chanock, Douglas F. Easton, Rosalind A. Eeles, Zsofia Kote-Jarai, David V. Conti, Christopher A. Haiman
59Citations signalées, ce qui n’est pas une note de qualité
179Institutions déclarées
21Pays d’affiliation déclarés
Rattachement africain : us, gb, au, se, fi, fr, dk, no, ca, es, pl, de, pt, be, my, bg, nl, jp, cn, sa, hr.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10−15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Germline variation at 8q24 and prostate cancer risk in men of European ancestry
- Date Crossref
- 05/11/2018
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Genetic Associations and EpidemiologyGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesGenetic and phenotypic traits in livestock