Thomas Schnoeller

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Anqi Wang, Jiayi Shen, Alex A Rodriguez, Edward J. Saunders et autres

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of …

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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Fredrik Wiklund, Elio Ríboli, Manuel Luedeke, Wayne D. Tilley et autres

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with …

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Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

David V. Conti, Burcu F. Darst, Lilit C. Moss, Edward J. Saunders et autres

A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00786-2.

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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

David V. Conti, Burcu F. Darst, Lilit C. Moss, Edward J. Saunders et autres

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with …

us, gb, jp, fi, au, pl, dk, se, ca, Ghana (code pays fourni par la source)

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Marco Matejcic, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook et autres

The original version of this Article contained an error in the spelling of the author Manuela Gago-Dominguez, which was incorrectly given as Manuela G. Dominguez. This has now been corrected in both the PDF and HTML versions of the Article.

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Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Fredrick R. Schumacher, Ali Amin Al Olama, Sonja I. Berndt, Sara Benlloch et autres

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Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Marco Matejcic, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook et autres

Abstract Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation …

us, gb, au, se, fi, fr, dk, no, ca, es, pl, de, pt, be, my, bg, nl (code pays fourni par la source)

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Fredrick R. Schumacher, Ali Amin Al Olama, Sonja I. Berndt, Sara Benlloch et autres

us, gb, es, au, se, fi, fr, dk, no, ca, cn, pl (code pays fourni par la source)

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Tokhir Dadaev, Edward J. Saunders, Paul J. Newcombe, Ezequiel Anokian et autres

Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, …

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