Variability of clinical target volume delineation for rectal cancer patients planned for neoadjuvant radiotherapy with the aid of the platform Anatom-e
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Le résumé fourni par la source
OBJECTIVE: Delineation of treatment volumes is a major source of uncertainties in radiotherapy (RT). This is also true for rectal cancer patients undergoing neoadjuvant RT, with a potential impact on treatment quality. We investigated the role of the digital platform Anatom-e (Anatom-e Information Sytems Ltd., Houston, Texas) in increasing the compliance to follow a specific treatment protocol in a multicentric setting. MATERIALS AND METHODS: Two clinical cases of locally advanced rectal cancer were chosen. Participants were instructed to follow the 2009 Radiation Therapy Oncology Group consensus atlas and asked to manually segment clinical target volumes (CTVs), for both patient 1 and 2, on day 1 with and without the use of Anatom-e. After one week (day 2), the same radiation oncologist contoured again, with and without Anatom-e, the same CT series. Intraobserver (Intra-OV) and interobserver (Inter-OV) variability were evaluated with the Dice similarity coefficient (DSC), the Hausdorff distance (HD) and mean distance to agreement (MDA). RESULTS: For clinical case 1, no significant difference was found for Intra-OV and Inter-OV. For clinical case 2, no significant difference was found for Intra-OV but a statistically significant difference was found for Inter-OV in DSC when using or not the platform. Mean DCS was 0.65 (SD: ±0.64; range: 0.58-0.79) for day 1 vs reference volume without Anatom-e and 0.72 (SD: ±0.39; range: 0.67-0.77) (p = 0.03) with it. Mean MDA was lower with Anatom-e (3.61; SD: ±1.33; range: 2.85-4.78) than without (4.14; SD: ±2.97; range: 2.18-5.21), with no statistical significance (p = 0.21) The use of Anatom-e decreased the SD from 2.97 to 1.33. Mean HD was lower with Anatom-e (26.06; SD: ±2.05; range: 24.08-32.62), with no statistical significance (p = 0.14) compared to that without (31.39; SD: ±1.31; range: 26.14-48.72). CONCLUSIONS: The use of Anatom-e decreased the Inter-OV in the CTV delineation process for locally advanced rectal cancer with complex disease presentation planned for neoadjuvant RT. This system may be potentially helpful in increasing the compliance to follow shared guidelines and protocols.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Variability of clinical target volume delineation for rectal cancer patients planned for neoadjuvant radiotherapy with the aid of the platform Anatom-e
- Date Crossref
- 01/06/2018
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Turin Department of Oncology pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera Citta' della Salute e della Scienza di Torino pays non établi dans la noticeÉtablissement de santé
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Ospedale Civile Di Ivrea pays non établi dans la noticeÉtablissement de santé
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Azienda Sanitaria Locale di Asti pays non établi dans la noticeÉtablissement de santé
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A. O. Ordine Mauriziano di Torino pays non établi dans la noticeÉtablissement de santé
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Ospedale San Luigi Gonzaga pays non établi dans la noticeÉtablissement de santé
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Ospedale San Giovanni Antica Sede pays non établi dans la noticeÉtablissement de santé
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Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo pays non établi dans la noticeÉtablissement de santé
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Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta pays non établi dans la noticeOrganisme public
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Department of Oncology pays non établi dans la noticeInstitution
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Department of Medical Physics pays non établi dans la noticeInstitution
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Ivrea Community Hospital Department of Radiation Oncology pays non établi dans la noticeÉtablissement de santé
Department of Oncology — University of Turin, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino et Ospedale Civile Di Ivrea, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.