Typical medullary breast carcinoma: clinical outcomes and treatment results
Rattachement africain : pl, pk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Typical medullary breast carcinoma (T-MBC) accounts for less than 1% of all malignant breast neoplasms, and immunohistochemically is characteristic of “triple-negative” breast carcinoma. The purpose of this study was to describe the clinical characteristics and treatment results for patients with T-MBC treated at a single institution, and discuss the controversial aspects of this very rare form of breast cancer. Analyses was performed in 120 patients with T-MBC who were treated between 1970 and 2005. These cases represent 1.1% of all (11 270) patients treated for breast cancer during this period. According to TNM classification, 26 patients (21.6%) were in stage I, 80 patients (66.7%) in stage II and 14 (11.7%) in stage III of clinically advanced breast cancer. Involved axillary lymph nodes occurred in just 10 (8.3%) of the patients, and in all cases metastases were observed in 1–3 lymph nodes. All the patients underwent primary surgery. Radical mastectomies were performed on 98 (81.6%) patients, while the other 22 (18.4%) underwent breast-conserving surgery (BCS). Radiotherapy was performed in 36 patients (22 after BCS and 14 after mastectomy). Patients with nodal involvement (10 patients) received adjuvant chemotherapy, and 8 patients with hormone receptor expression received hormonotherapy with tamoxifen. The 10-year DFS rate was 90%. Out of 120 patients with T-MBC, only 4 (3.3%) died from this cancer. We showed that none of the population, neither clinical nor microscopic, had a statistically significant influence on the 10-year disease-free survival rate. Our results are similar to others presented in literature.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Typical medullary breast carcinoma: clinical outcomes and treatment results
- Date Crossref
- 25/08/2017
- Éditeur
- VM Media SP. zo.o VM Group SK
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Maria Sklodowska-Curie National Research Institute of Oncology pays non établi dans la noticeÉtablissement de santé
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St. Raphael's Hospital pays non établi dans la noticeÉtablissement de santé
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Clinic of Surgical Oncology pays non établi dans la noticeÉtablissement de santé
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Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology Department of Tumour Pathology pays non établi dans la noticeStructure de recherche
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St. Raphael Hospital Deparment of Surgery pays non établi dans la noticeÉtablissement de santé
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Associate Professor Clinic of Oncology Maria Skłodowska-Curie pays non établi dans la noticeÉtablissement de santé
The Maria Sklodowska-Curie National Research Institute of Oncology, St. Raphael's Hospital et Clinic of Surgical Oncology, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.