Elżbieta Pluta

Results of repeat proton beam radiotherapy in patients with locoregional recurrence or a second primary tumor in a previously irradiated area

Elżbieta Pluta, Anna Patla, Tomasz Skóra, Anna Chrostowska et autres

Introduction. Re-irradiation for locoregional recurrence or second primary tumors in previously irradiated regions is constrained by cumulative organ-at-risk tolerance. Proton therapy may improve dose conformality and spare critical structures. Material and methods. We retrospectively reviewed 91 patients treated with repeat proton beam …

hu, pl (code pays fourni par la source)

The Clinical outcomes following pencil beam scanning proton therapy for skull base chordoma and chondrosarcoma: a single-institution experience

Tomasz Skóra, Kamila Rawoj´c, Joanna Anioł, Tomasz Banaś et autres

BACKGROUND: Chordomas and chondrosarcomas of the skull base are rare, locally aggressive tumors that pose significant therapeutic challenges due to their proximity to critical anatomical structures. While maximal safe surgical resection remains the cornerstone of management, the infiltrative nature of these tumors …

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The Prognostic Potential of PD-L1, PD-1, CD3, CD4, and CD8 Expression in Patients with Head and Neck Cancers Depending on HPV16 Infection

Anna Mucha-Małecka, Beata Biesaga, Natalia Amrogowicz, Aleksandra Grela-Wojewoda et autres

Objective: The aim of this study was to evaluate the expression of PD-L1, PD-1, CD3, CD4, and CD8 in tumor tissues of patients with head and neck squamous cell carcinoma from southern Poland, and to assess their prognostic value in relation to …

hu, pl (code pays fourni par la source)

The Prognostic Potential of PD-L1, PD-1, CD3, CD4, and CD8 Expression in Patients with Head and Neck Cancers Depending on HPV16 Infection.

Anna Mucha-Małecka, Natalia Amrogowicz, Krzysztof Małecki, Krzysztof Wójcicki et autres

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Levels of Systemic Inflammatory Markers in Women with Cervical Cancer Undergoing Definitive Chemoradiotherapy Depend Primarily on Pre-treatment and Post-teletherapy Tumor Volume, Rather than on the Prescribed Radiation Dose

Krzysztof Bereza, Tomasz Banaś, Beniamin Oskar Grabarek, Aleksandra Czerw et autres

INTRODUCTION/OBJECTIVE: Cervical cancer (CC) remains a major global health problem, especially in advanced stages. Systemic inflammatory markers such as the neutrophil-tolymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) have been proposed as prognostic indicators. This study …

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Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1

Wojciech Czestkowski, Łukasz Krzemiński, Michał Piotrowicz, Marzena Mazur et autres

Chitinase-3-like-1 (CHI3L1), also known as YKL-40, is a glycoprotein linked to inflammation, fibrosis, and cancer. This study explored CHI3L1’s interactions with various oligosaccharides using microscale thermophoresis (MST) and AlphaScreen (AS). These investigations guided the development of high-throughput screening assays to assess interference …

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Trends in Systemic Inflammatory Reaction (SIR) during Paclitaxel and Carboplatin Chemotherapy in Women Suffering from Epithelial Ovarian Cancer

Michał Mleko, Elżbieta Pluta, Kazimierz Pityński, Maciej Bodzek et autres

Background: Epithelial ovarian cancer (EOC) is the most fatal gynaecological malignancy treated with cytoreductive surgery followed by adjuvant taxane-platinum-based chemotherapy. It has been shown that the pretreatment systemic inflammatory reaction (SIR) in women with OC can be evaluated using the neutrophil-to-lymphocyte ratio …

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Results of the treatment of adrenocortical cancer patients at the Maria Sklodowska-Curie National Research Institute of Oncology – Krakow Branch

Elżbieta Pluta, Magdalena Michta, Anna Patla, Anna Mucha-Małecka et autres

Introduction. Adrenocortical carcinoma (ACC) has an incidence of 1–2 cases per million and the 5-year overall survival (OS) is 16–47%. Surgery is the treatment of choice. Post-operative radiotherapy has been shown to prolong overall survival and the purpose of this work was …

Evaluating the Efficacy of Low Dose Radiotherapy in the Treatment of Painful, Benign Musculoskeletal Conditions

Elżbieta Pluta, Michał Ciepiela, Anna Patla, Anna Mucha-Małecka et autres

Introduction: Inflammatory diseases of the locomotor system are a very heterogeneous group of ailments, including enthesopathies. They arise as a result of long-term overload in the area of tendon attachments, which may lead to chronic inflammation and then, degeneration, which are the …

The Direct and Indirect Costs of Breast Cancer in Poland: Estimates for 2017–2019

Michał Seweryn, Tomasz Banaś, Joanna Augustynska, Ola Lorenc et autres

BACKGROUND: In Poland, breast cancer (BC) is the most frequently diagnosed cancer in women and the second most common cause of death after lung cancer. This disease has important economic implications for patients, public payers, and the whole Polish economy. This study …

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Complex grade III astrocytoma with granular cells and PXA features in a patient with tuberous sclerosis complex (Bourneville-Pringle syndrome) – case report and review of literature

Anna Mucha-Małecka, Krzysztof Małecki, Michał Kurzyński, Dariusz Adamek et autres

Tuberous sclerosis complex (Bourneville-Pringle syndrome) is a rare genetic condition included in the group of diseases called phakomatoses. Most of the patients are diagnosed with abnormalities within the central nervous system and tend to develop tumors more frequently, especially gliomas. We present …

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Role of Systemic Inflammatory Reaction in Female Genital Organ Malignancies – State of the Art

Michał Mleko, Kazimierz Pityński, Elżbieta Pluta, Aleksandra Czerw et autres

Abstract: Systemic inflammatory reaction (SIR) is an unfavorable prognostic factor in many malignancies and has a role in all stages of the neoplastic process: initiation, promotion, and disease progression. Analysis of SIR can be performed by assessing indicators (eg, lymphocyte-to-neutrophil, platelet-to-lymphocyte, and …

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