Accès ouvert déclaré 2017 preprint

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

Gail Davies, Max Lam, Sarah E. Harris, Joey W. Trampush, Michelle Luciano, W. David Hill, Saskia P. Hagenaars, Stuart J. Ritchie, Riccardo E. Marioni, Chloe Fawns‐Ritchie, David C. Liewald, Judith A. Okely, Ari Ahola‐Olli, Catriona L. K. Barnes, Lars Bertram, Katherine E. Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella G. Giakoumaki, Sudheer Giddaluru, Daniel E. Gustavson, Caroline Hayward, Edith Hofer, M. Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A. Mather, Ingrid Melle, Derek W. Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A. Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A. Smith, Albert V. Smith, Natalie Terzikhan, Anbupalam Thalamuthu, Stella Trompet, Sven J. van der Lee, Erin B. Ware, B. Gwen Windham, Margaret J. Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A. Andreassen, Nicola J. Armstrong, Amelia A. Assareh, John Attia, Deborah K. Attix, Dimitrios Avramopoulos, David A. Bennett, Anne C. Böhmer, Patricia A. Boyle, Henry Brodaty, Harry Campbell, Tyrone D. Cannon, Elizabeth T. Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Anders M. Dale, Abbas Dehghan, Danielle M. Dick, Dwight Dickinson, Johan G. Eriksson, Εvangelos Εvangelou, Jessica D. Faul, Ian Ford, Nelson B. Freimer, He Gao, Ina Giegling, Nathan A. Gillespie, Scott D. Gordon, Rebecca F. Gottesman, Michael Griswold, Vilmundur Guðnason, Tamara B. Harris, Annette M. Hartmann, Alex Hatzimanolis, Gerardo Heiss, Peter K. Joshi, Mika Kähönen, Sharon LR Kardia, Ida Karlsson, Luca Kleineidam, David S. Knopman, Nicole A. Kochan, Bettina Konte, John B. Kwok, Stéphanie Le Hellard, Teresa Lee, Terho Lehtimäki, Shu Li, Tian Liu, Marisa Koini, Edythe London, W. T. Longstreth, Oscar L. López, Anu Loukola, Tobias Luck, Astri J. Lundervold, Anders Lundquist, Leo‐Pekka Lyytikäinen, Nicholas G. Martin, Grant W. Montgomery, Anna C. Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polašek, Russell A. Poldrack, Bruce M. Psaty, Simone Reppermund, Steffi G. Riedel‐Heller, Richard J. Rose, Jerome I. Rotter, Panos Roussos, Suvi P. Rovio, Yasaman Saba, Fred W. Sabb, Perminder S. Sachdev, Claudia L. Satizábal, Matthias Schmid, Rodney J. Scott, Matthew A. Scult, Jeannette Simino, P. Eline Slagboom, Nikolaos Smyrnis, Aïcha Soumaré, Nikos C. Stefanis, David J. Stott, Richard E. Straub, Kjetil Sundet, Adele Taylor, Kent D. Taylor, Ioanna Tzoulaki, Christophe Tzourio, André G. Uitterlinden, Véronique Vitart, Aristotle N. Voineskos, Jaakko Kaprio, Michael Wagner, Holger Wagner, Leonie Weinhold, Kexin Wen, Elisabeth Widén, Qiong Yang, Wei Zhao, Hieab H.H. Adams, Dan E. Arking, Robert M. Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba‐Falek, Aiden Corvin, Philip L. De Jager, Stéphanie Debette, Gary Donohoe, Paul Elliott, Annette L. Fitzpatrick, Michael Gill, David C. Glahn, Sara Hägg, Narelle K. Hansell, Ahmad R. Hariri, M. Kamran Ikram, J. Wouter Jukema, Eero Vuoksimaa, Matthew C. Keller, William S. Kremen, Lenore J. Launer, Ulman Lindenberger, Aarno Palotie, Nancy L. Pedersen, Neil Pendleton, David J. Porteous, Katri Räikkönen, Olli T. Raitakari, Alfredo Ramı́rez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W. Schofield, Peter R. Schofield, John M. Starr, Vidar M. Steen, Julian N. Trollor, Steven T. Turner, Cornelia M. van Duijn, Arno Villringer, Daniel R. Weinberger, David R. Weir, James F. Wilson, Anil K. Malhotra, Andrew M. McIntosh, Catharine R. Galé, Sudha Seshadri, Thomas H. Mosley, Jan Bressler, Todd Lencz, Ian J. Deary

12Citations signalées, ce qui n’est pas une note de qualité

137Institutions déclarées

17Pays d’affiliation déclarés

Rattachement africain : gb, sg, fi, ca, de, us, no, gr, at, nl, se, au, ie, fr, is, be, hr. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

General cognitive function is a prominent human trait associated with many important life outcomes 1,2 , including longevity 3 . The substantial heritability of general cognitive function is known to be polygenic, but it has had little explication in terms of the contributing genetic variants 4,5,6 . Here, we combined cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N=280,360; age range = 16 to 102). We found 9,714 genome-wide significant SNPs ( P <5 x 10 −8 ) in 99 independent loci. Most showed clear evidence of functional importance. Among many novel genes associated with general cognitive function were SGCZ , ATXN1 , MAPT , AUTS2 , and P2RY6 . Within the novel genetic loci were variants associated with neurodegenerative disorders, neurodevelopmental disorders, physical and psychiatric illnesses, brain structure, and BMI. Gene-based analyses found 536 genes significantly associated with general cognitive function; many were highly expressed in the brain, and associated with neurogenesis and dendrite gene sets. Genetic association results predicted up to 4% of general cognitive function variance in independent samples. There was significant genetic overlap between general cognitive function and information processing speed, as well as many health variables including longevity.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)
Date Crossref: 17/08/2017
Éditeur: openRxiv
Type: posted-content

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

University of Edinburgh Institute of Mental Health Western General Hospital Institute of Genetics and Cancer King's College London University of Turku Satakunta Central Hospital Centre for Global Health Research Max Planck Institute for Molecular Genetics University of Washington Brigham and Women's Hospital Harvard University James J. Peters VA Medical Center Icahn School of Medicine at Mount Sinai Haukeland University Hospital University of Bergen Feinstein Institute for Medical Research Oslo University Hospital University of Oslo University of Crete University of California San Diego Medical Research Council Medical University of Graz Erasmus MC Karolinska Institutet Yale University University of Helsinki University of the Arts Helsinki University of Cologne Boston University Max Planck Institute for Human Development Technische Universität Dresden UNSW Sydney Centre for Healthy Brain Ageing Ollscoil na Gaillimhe – University of Galway Institute for Molecular Medicine Finland University of Manchester Imperial College London University of California, Riverside Université de Bordeaux Inserm Bordeaux Population Health Life University Leipzig University University of Michigan University of Iceland Icelandic Heart Association Ghent University Hospital Leiden University Medical Center University of Mississippi Medical Center The University of Queensland National Imaging Facility Rush University Medical Center The Royal Melbourne Hospital The University of Melbourne National Ageing Research Institute St George Hospital Université de Lille Institut Pasteur de Lille Centre Hospitalier Universitaire de Lille Murdoch University Hunter Medical Research Institute Duke University Duke Medical Center Duke University Hospital Johns Hopkins University Johns Hopkins Medicine University of Bonn Life & Brain (Germany)Dementia Collaborative Research Centres Human Longevity (United States)23andMe (United States)Virginia Commonwealth University National Institute of Mental Health Helsinki University Hospital Finnish Institute for Health and Welfare Folkhälsans Forskningscentrum University of Glasgow Martin Luther University Halle-Wittenberg QIMR Berghofer Medical Research Institute Jackson Memorial Hospital National Institutes of Health Institute on Aging National and Kapodistrian University of Athens University Mental Health Research Institute Eginition Hospital University of North Carolina at Chapel Hill Tampere University Tampere University Hospital Tampere University German Center for Neurodegenerative Diseases Mayo Clinic in Arizona Prince of Wales Hospital The University of Sydney Fimlab (Finland)University of Pittsburgh Umeå University University of Aberdeen Stockholm University University of Split Palo Alto University Stanford University Kaiser Permanente Washington Health Research Institute Indiana University The Lundquist Institute UCLA Medical Center Harbor–UCLA Medical Center University of Oregon Zimmer Biomet (Germany)Lieber Institute for Brain Development University of Ioannina Centre for Addiction and Mental Health University of Toronto Erasmus University Rotterdam Baylor College of Medicine Baylor Genetics The University of Texas Health Science Center at Houston Trinity College Dublin Broad Institute Columbia University Irving Medical Center University of Colorado Boulder Wellcome Sanger Institute Manchester Academic Health Science Centre Turku University Hospital University of Newcastle Australia Neuroscience Research Australia Alzheimer Scotland Mayo Clinic WinnMed University Hospital Leipzig Max Planck Institute for Human Cognitive and Brain Sciences Hofstra University Zucker Hillside Hospital MRC Lifecourse Epidemiology Unit University of Southampton National Heart, Lung, and Blood Institute Framingham Heart Study

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Genetics and Neurodevelopmental DisordersCongenital heart defects researchGenomics and Rare Diseases

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