Mast Cell Disorders, Melanoma and Pancreatic Carcinoma: From a Clinical Observation to a Brief Review of the Literature.
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Mastocytosis can be associated with other clonal or non-clonal hematologic diseases as well as a variety of non-hematologic malignancies. A 75-year-old Caucasian male patient was referred to us with a 5-month history of neutrophilic leukocytosis and mild splenomegaly. He had developed a cutaneous melanoma sixteen years ago. According to the clinical and pathological features, a final diagnosis of systemic mastocytosis was established. The patient started treatment with interferon-α at a dose of 3 MIU/day, combined with low doses of prednisone. We observed a rapid disappearance of symptoms. Unfortunately, after 3 months a diagnosis of pancreatic adenocarcinoma was established. A review of the literature suggests that mastocytes could have a pivotal role in several malignancies. Different chemokines, mitogenic factors, chemical mediators of inflammation, and specific gene mutations could explain the association between mastocytosis and other hematologic and non-hematologic disorders.
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Sapienza University of Rome pays non établi dans la noticeUniversité ou école supérieure
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University of Bari Aldo Moro pays non établi dans la noticeUniversité ou école supérieure
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Istituto Dermopatico dell'Immacolata pays non établi dans la noticeÉtablissement de santé
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Dario Didona pays non établi dans la noticeInstitution
Sapienza University of Rome, University of Bari Aldo Moro et Istituto Dermopatico dell'Immacolata, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.