Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
565Citations signalées, ce qui n’est pas une note de qualité
277Institutions déclarées
30Pays d’affiliation déclarés
Rattachement africain : us, gb, kr, au, ca, nl, by, gr, de, se, it, es, fr, is, ru, no, dk, fi, be, pl, Afrique du Sud, il, lt, hk, hu, pt, at, my, lv, Éthiopie. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1. To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
- Date Crossref
- 27/03/2017
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Moffitt Cancer CenterUniversity of CambridgeWellcome Sanger InstituteMRC Epidemiology UnitCedars-Sinai Medical CenterMayo Clinic in FloridaDuke Medical CenterUlsan CollegeAsan Medical CenterQIMR Berghofer Medical Research InstituteCentre hospitalier universitaire de QuébecUniversité LavalAmsterdam UMC Location University of AmsterdamRadboud University NijmegenRadboud University Medical CenterNetherlands Comprehensive Cancer OrganisationJohns Hopkins UniversityJohns Hopkins MedicineChapel Allerton HospitalMount Sinai HospitalUniversity of TorontoLunenfeld-Tanenbaum Research InstituteUniversity of California, IrvineCancer Genetics (United States)N.N. Alexandrov National Cancer CentreHospital Agioi AnargyroiChristian-Albrechts-Universität zu KielThe University of Texas MD Anderson Cancer CenterKarolinska University HospitalKarolinska InstitutetFondazione IRCCS Istituto Nazionale dei TumoriVall d'Hebron Hospital UniversitariRoyal Marsden HospitalCentre Léon BérardNational University Hospital of IcelandReykjavík UniversityUniversity of IcelandOregon Health & Science UniversityComprehensive Cancer Center ErlangenVanderbilt UniversitySpanish National Cancer Research CentreVanderbilt HealthVanderbilt-Ingram Cancer CenterVanderbilt University Medical CenterRussian Academy of SciencesCentre for Biomedical Network Research on Rare DiseasesUniversity Health NetworkPrincess Margaret Cancer CentreMassachusetts General HospitalHaukeland University HospitalNational Cancer InstituteDivision of Cancer Epidemiology and GeneticsUniversity of BergenCity Of Hope National Medical CenterCity of HopeResearch Network (United States)Maastricht UniversityMedizinische Hochschule HannoverVejle SygehusEuropean Institute of OncologyLund UniversitySkåne University HospitalUniversity of PennsylvaniaCancer Research UK Cambridge CenterRoyal Devon and Exeter HospitalBC Cancer AgencyCanada's Michael Smith Genome Sciences CentreCancer Council VictoriaInstitut Català d'OncologiaInstitut d'Investigació Biomèdica de GironaInstitut CurieUniversity of HelsinkiHelsinki University HospitalHuntsman Cancer InstituteInstituto de Investigación Sanitaria del Hospital Clínico San CarlosAzienda Ospedaliera Universitaria PisanaPeter MacCallum Cancer CentreRoswell Park Comprehensive Cancer CenterThe University of MelbourneUniversity of Hawaiʻi at MānoaUniversity of California, San FranciscoGerman Cancer Research CenterHeidelberg UniversityUniversität HamburgUniversity Medical Center Hamburg-EppendorfUniversity Cancer Center HamburgThe University of SydneyWestmead Institute for Medical ResearchWestmead HospitalColumbia UniversityGhent University HospitalUniversity of New MexicoSheffield Children's HospitalBrigham and Women's HospitalHarvard UniversityMayo ClinicSocial and Scientific Systems (United States)Fox Chase Cancer CenterBashkir State UniversityThe Maria Sklodowska-Curie National Research Institute of OncologyMemorial Sloan Kettering Cancer CenterCentre d'Investigation Clinique de NantesHôpital NOVOVall d'Hebron Institute of OncologyBeckman Research InstituteDartmouth CollegeUniversity of PretoriaCentre international de recherche sur le cancerUniversidad de ValladolidInstituto de Biomedicina y Genética Molecular de ValladolidJena University HospitalFriedrich Schiller University JenaUniversity of SouthamptonRoyal Marsden NHS Foundation TrustInstitute of Cancer ResearchCopenhagen University HospitalRigshospitaletFriedrich-Alexander-Universität Erlangen-NürnbergLeipzig UniversityManchester Academic Health Science CentreUniversity of ManchesterUniversity of California, Los AngelesImperial College LondonNational Centre of Scientific Research "Demokritos"McGill UniversityAristotle University of ThessalonikiPapageorgiou General HospitalUniversity of Kansas Medical CenterDana-Farber Cancer InstituteSheba Medical CenterTel Aviv UniversityUCLA Jonsson Comprehensive Cancer CenterUniversity of WürzburgUniversity College LondonBeatson West of Scotland Cancer CentreMonash UniversityUniversity of UtahNational Institutes of HealthPomeranian Medical UniversityUniversity of Southern CaliforniaUniversity Hospital CologneDepartment of Health and Human ServicesDKFZ-ZMBH AllianceCentre for LifeNewcastle upon Tyne HospitalSt George's, University of LondonUniversity of CopenhagenDanish Cancer SocietyThe Netherlands Cancer InstituteErasmus MCHerlev HospitalEndeavor HealthUniversity of ChicagoUniversity of British ColumbiaInstitute of Oncology NN PetrovGeorgetown UniversityGeorgetown University Medical CenterDuke UniversityGuy's and St Thomas' NHS Foundation TrustVilnius UniversityAarhus University HospitalCancer Prevention Institute of CaliforniaState Research Institute Centre for Innovative MedicineUniversity Hospital Carl Gustav CarusThe Catholic University of Korea Seoul St. Mary's HospitalUniversity of CalgaryOdense University HospitalBasque GovernmentInstitut d'Investigació Biomédica de BellvitgeHong Kong Sanatorium and HospitalUniversity of Hong KongUniversity of Hawaii SystemCancer Center of HawaiiUniversity of Hawaii Cancer CenterKU LeuvenCentro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaCentre Hospitalier Universitaire de GrenobleUniversité Grenoble AlpesInsermUniversité Paris Sciences et LettresTexas Southern UniversityFraunhofer Project Centre WolfsburgÉcole Nationale Supérieure des Mines de ParisLyon 1 UniversitéCentre National de la Recherche ScientifiqueCentre de Recherche en Cancérologie de LyonVancouver General HospitalStanford UniversityPublic Health OntarioCancer Research UK Scotland InstituteUniversity of GlasgowAmsterdam UMC Location Vrije Universiteit AmsterdamTUM KlinikumTechnical University of MunichStanford Health CareUniversity of PittsburghIstituto Oncologico VenetoIstituti di Ricovero e Cura a Carattere ScientificoSt. Michael's HospitalMagee-Womens Research InstituteThe University of Texas Health Science Center at HoustonDüsseldorf University HospitalHeinrich Heine University DüsseldorfInvitae (United States)National Institute of OncologyUniversity of Chicago Medical CenterThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteBirmingham Women's HospitalUniversity Medical Center UtrechtBreast Cancer NowPiedmont Reference Center for Epidemiology and Cancer PreventionUniversity of FlorenceAalborg University HospitalInstituto Português de Oncologia Francisco GentilCancer Research UKCancer Research UK Clinical Trials UnitUniversity of MichiganIFOMComprehensive Cancer Center ViennaMedical University of ViennaNRG OncologyWestern General HospitalCentre Hospitalier Universitaire de Saint-ÉtienneHôpital Arnaud de VilleneuveHaifa Medical CenterDana-Farber Brigham Cancer CenterCarmel Medical CenterCentro de Investigación del CáncerOncode InstituteFred Hutch Cancer CenterNational Institute of Environmental Health SciencesUniversité Paris-SudGlasgow Royal InfirmaryGreat Ormond Street HospitalUniversité Paris-SaclayInstitut Gustave RoussyItalian institute for Genomic MedicineInstitut Paoli-CalmettesUniversity of South FloridaUniversity Hospital HeidelbergNational Human Genome Research InstituteCancer Research MalaysiaSubang Jaya Medical CentreMagee-Womens HospitalLatvian Biomedical Research and Study CentreUniversidade do PortoUniversity Malaya Medical CentreAddenbrooke's HospitalUniversity of OxfordOvarian Cancer CanadaHellenic Health FoundationBeth Israel Deaconess Medical CenterUniversity Medical Center GroningenUniversity of GroningenNational and Kapodistrian University of AthensCharité - Universitätsmedizin BerlinFundación Pública Galega de Medicina XenómicaServicio Gallego de SaludUniversidade de Santiago de CompostelaChurchill HospitalCenter for Research in Molecular Medicine and Chronic DiseasesUniversity Hospital LeipzigUniversität UlmLeiden University Medical CenterStanford MedicineWomen's College HospitalUniversity of VirginiaUNSW SydneySapienza University of RomeSeoul National UniversityDartmouth Institute for Health Policy and Clinical PracticeMedical University of South CarolinaDartmouth Psychiatric Research CenterYale UniversityGarvan Institute of Medical ResearchSeoul National University of Science and TechnologyNew Generation University College
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
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