Tomasz Huzarski

Combined Effects of Selenium, Arsenic, and CAT rs1001179 Genotype on Cancer Risk in Women with Familial Breast Cancer Predisposition

Jan Lubiński, Antoni Morawski, Wojciech Marciniak, Tomasz Huzarski et autres

(1) Background: Selenium (Se) and arsenic (As) influence oxidative stress pathways and may jointly affect cancer risk. We investigated whether Se and As status, individually and in combination, are associated with cancer incidence in women with familial breast cancer predisposition. (2) Methods: …

PCSK9 rs562556 variant and survival in BRCA1 mutation carriers and mutation-negative familial breast cancer

Cezary Cybulski, Wojciech Kluźniak, Dominika Wokołorczyk, Neda Zamani et autres

Breast cancer etiology involves a complex interplay of various risk factors, with genetic alterations playing a significant role in susceptibility to the disease. While mutations in genes such as BRCA1 and BRCA2 are well established in elevating breast cancer risk, their potential …

pl, ca (code pays fourni par la source)

Association analysis of germline variants in GEN1 with a susceptibility to prostate cancer in Polish men

Katarzyna Gliniewicz, Klaudia Stempa, Dominika Wokołorczyk, Wojciech Kluźniak et autres

BACKGROUND: The GEN1 gene is involved in DNA damage repair, as are several prostate cancer susceptibility genes, and is now included in several NGS clinical testing panels. The aim of our study was to investigate the role of GEN1 mutations in the …

pl, ca (code pays fourni par la source)

Are current Polish guidelines for prophylactic mastectomy sufficient?

Adam Stachowski, Cezary Cybulski, Jacek Gronwald, Tomasz Huzarski et autres

AIM: Due to the expansion of knowledge about genetic predispositions to breast cancer, the International Hereditary Cancer Center in Szczecin has been solicited to update the Polish ministerial guidelines for the qualification of patients who should be offered prophylactic mastectomy. METHODS: This …

pl, ca, au (code pays fourni par la source)

Germline ATRIP variants and the risk of ovarian cancer

Neda Zamani, Dominika Wokołorczyk, Wojciech Kluźniak, Alicja Ogrodniczak et autres

PURPOSE: We have previously reported that inherited variants in ATRIP confer a 3-fold risk of developing breast cancer. Here, we investigated potential association between this novel breast cancer susceptibility gene and the risk of ovarian cancer. METHODS: We genotyped the ATRIP c.1152_1155del …

ca, pl (code pays fourni par la source)

All-Cause Mortality and Cancer Risk Dependent on Blood Se Level and HRG rs10770 Genotypes on a Prospective Cohort of Women with Familial Breast Cancers

Krzysztof Lubiński, Adam Stachowski, Wojciech Marciniak, Róża Derkacz et autres

The aim of this study was to investigate whether genotypes of HRG may modify the effect of Se(selenium) on all-cause mortality and cancer risk. The study was conducted on 2782 initially unaffected women from families with familial breast cancers, all registered at …

pl, au (code pays fourni par la source)

Adverse event profile following maintenance olaparib in patients with BRCA-mutated platinum-sensitive relapsed serous ovarian cancer in the phase III SOLO2 trial

Jonathan A. Ledermann, Alain H. Lortholary, Richard T. Penson, Rebecca Asher et autres

OBJECTIVE: To characterize the occurrence, duration, and outcomes of the most common non-hematological (nausea, vomiting, fatigue/asthenia) and hematological (anemia, neutropenia) adverse events experienced by patients receiving olaparib in the phase III SOLO2 trial. METHODS: SOLO2 (NCT01874353) is a randomized, double-blind, placebo-controlled trial. …

gb, fr, us, au, ca, il, pl, es, it, de, jp, nl, ru, kr, br (code pays fourni par la source)

Evidence for Genotype-Specific Optimal Blood Lead Levels for Cancer Risk: MKI67 rs11016073 and APOB rs1367117 in a Female Prospective Cohort

Krzysztof Lubiński, Wojciech Marciniak, Róża Derkacz, Adam Kiljańczyk et autres

This study’s aim was to clarify the regulatory roles of the MKI67 rs11016073 and APOB rs1367117 polymorphisms in the relationship between blood Pb levels and cancer risk. Blood Pb concentrations were measured using inductively coupled plasma mass spectrometry, and genotyping was performed …

pl, au (code pays fourni par la source)

An international cohort study of breast cancer survival in young women

Victoria Sopik, Jan Lubiński, Jacek Gronwald, Tomasz Huzarski et autres

BACKGROUND: There is large variation in case-fatality rates of breast cancer in young women across the world. The objective of this study was to estimate the ten-year overall survival of women diagnosed with breast cancer before age 40 in six countries, by …

ca, pl, is, ir, fr, th, us (code pays fourni par la source)

Menopausal hormone therapy and the risk of breast cancer in women with a pathogenic variant in BRCA1 or BRCA2

Joanne Kotsopoulos, Marta Seca, Jacek Gronwald, Tomasz Huzarski et autres

BACKGROUND: Women with a pathogenic variant in BRCA1 or BRCA2 are at high risk of developing ovarian cancer, and it is often recommended that they undergo bilateral salpingo-oophorectomy at an early age, resulting in surgical menopause. Menopausal hormone replacement therapy (HRT) is …

us, ca, it, pl, no, at, es (code pays fourni par la source)

Supplementary Figures S1-S13 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher, Kylie L. Gorringe, Matthew J. Wakefield, Adelyn Bolithon et autres

Supplementary Figures S1-S13

Table 2 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher, Kylie L. Gorringe, Matthew J. Wakefield, Adelyn Bolithon et autres

Overall survival in MOC by pattern of invasion.