Rate, correlates and outcomes of repeat pregnancy in HIV ‐infected women
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Le résumé fourni par la source
OBJECTIVES: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. METHODS: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. RESULTS: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs. 33 years, respectively), more recently diagnosed with HIV infection (median time since diagnosis 25 vs. 51 months, respectively), and more frequently of foreign origin [odds ratio (OR) 1.36; 95% confidence interval (CI) 1.10-1.68], diagnosed with HIV infection in the current pregnancy (OR: 1.69; 95% CI: 1.35-2.11), and at their first pregnancy (OR: 1.33; 95% CI: 1.06-1.66). In women with sequential pregnancies, compared with the first pregnancy, several outcomes showed a significant improvement in the second pregnancy, with a higher rate of antiretroviral treatment at conception (39.0 vs. 65.4%, respectively), better median maternal weight at the start of pregnancy (60 vs. 61 kg, respectively), a higher rate of end-of-pregnancy undetectable HIV RNA (60.7 vs. 71.6%, respectively), a higher median birth weight (2815 vs. 2885 g, respectively), lower rates of preterm delivery (23.0 vs. 17.7%, respectively) and of low birth weight (23.4 vs. 15.4%, respectively), and a higher median CD4 cell count (+47 cells/μL), with almost no clinical progression to Centers for Disease Control and Prevention stage C (CDC-C) HIV disease (0.3%). The second pregnancy was significantly more likely to end in voluntary termination than the first pregnancy (11.4 vs. 6.1%, respectively). CONCLUSIONS: Younger and foreign women were more likely to have a repeat pregnancy; in women with sequential pregnancies, the second pregnancy was characterized by a significant improvement in several outcomes, suggesting that women with HIV infection who desire multiple children may proceed safely and confidently with subsequent pregnancies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Rate, correlates and outcomes of repeat pregnancy in <scp>HIV</scp>‐infected women
- Date Crossref
- 21/12/2016
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Istituto Superiore di Sanità pays non établi dans la noticeOrganisme public
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Università Cattolica del Sacro Cuore pays non établi dans la noticeUniversité ou école supérieure
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University of Turin pays non établi dans la noticeUniversité ou école supérieure
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Federico II University Hospital pays non établi dans la noticeÉtablissement de santé
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University of Pavia Department of Obstetrics and Gynaecology pays non établi dans la noticeUniversité ou école supérieure
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani pays non établi dans la noticeÉtablissement de santé
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University of Bari Aldo Moro Department of Obstetrics and Gynaecology pays non établi dans la noticeUniversité ou école supérieure
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IRCCS Materno Infantile Burlo Garofolo pays non établi dans la noticeÉtablissement de santé
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Policlinico San Matteo Fondazione pays non établi dans la noticeÉtablissement de santé
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University of Milan Department of Obstetrics and Gynaecology pays non établi dans la noticeUniversité ou école supérieure
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Ospedale San Paolo pays non établi dans la noticeÉtablissement de santé
Istituto Superiore di Sanità, Università Cattolica del Sacro Cuore et University of Turin, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.